Biography

Joseph A. Maldjian, MD, is Professor of Radiology at UT Southwestern, and serves as Chief of the Neuroradiology Division and Director of the Advanced Neuroscience Imaging Research Lab. His clinical interests involve bringing novel imaging methodologies and advanced analysis methods into the clinical setting.

What I really appreciate about neuroradiology at UT Southwestern is the perfect partnering of clinical and research excellence.

After receiving his bachelor’s degree in biochemistry from Princeton University, Dr. Maldjian earned his medical degree from the University of Medicine and Dentistry of New Jersey in Newark. He completed his residency training in diagnostic radiology at Mount Sinai Medical Center in New York, and then received advanced training in neuroradiology through a two-year fellowship at the University of Pennsylvania School of Medicine in Philadelphia.

Before joining the faculty at UT Southwestern, Dr. Maldjian served as a Professor of Radiology and Biomedical Engineering at Wake Forest University School of Medicine in Winston-Salem, North Carolina. Prior to that, he held faculty appointments at the Hospital of the University of Pennsylvania, and at New Jersey Medical School.

Investigating traumatic brain injuries

Dr. Maldjian’s research team has been instrumental in bringing arterial spin-labeling (ASL) into routine clinical practice. This noninvasive method “tags” arterial blood water through a process of magnetic inversion, making it possible for a magnetic resonance imaging (MRI) scanner to detect the “magnetized” blood flowing through brain tissue. He has also developed fully automated means for processing, archiving and analyzing these images, as well as images obtained using functional MRI, diffusion tensor imaging, positron emission tomography, and magnetoencephalography (MEG). Dr. Maldjian’s research lab maintains a data processing resource that can handle large amounts of neuroimaging data and provide an interface to an array of commonly used software platforms.

The main focus of Dr. Maldjian’s research is sports-related, mild traumatic brain injury. He is currently one of only a few radiologists in the nation to serve as principal investigator on three active National Institutes of Health (NIH)-funded R01 studies. Dr. Maldjian and his collaborators are studying the effects of sub-concussive impacts on youth and high school football players by obtaining MRI, MEG, cognitive measures and detailed head impact data from sensors embedded in players’ helmets.

He is also investigating whether genetic and racial factors related to diabetes might lead to changes in the brain structure and function in African-Americans.

Dr. Maldjian is an active member of numerous national and international societies, including the International Society for Magnetic Resonance in Medicine, American Society of Neuroradiology, American Society for Functional Neuroradiology, American College of Radiology, American Board of Radiology, and the Radiological Society of North America.

Robust editorial activity

In addition to authoring more than 125 peer-reviewed publications and over 15 additions to textbooks, Dr. Maldjian is a reviewer for multiple academic journals, including Radiology, Neuroradiology, Neurology, Neuroimage, Clinical Neuroradiology, American Journal of Neuroradiology, Annals of Biomedical Engineering, Neuroinformatics, and Journal of Computer Assisted Tomography. He also serves as a charter member of the NIH Biomedical Imaging Technology Study Section A.

Personal note

Dr. Maldjian is a trained classical pianist who spends much of his free time with his wife designing, testing, and optimizing novel reward systems to get their four young children to practice the instrument.

Education

Medical School
University of Medicine and Dentistry - New Jersey Medical School (1988)
Internship
St Barnabas Medical Center (1989), Internal Medicine
Residency
Icahn School of Medicine at Mount Sinai (1993), Diagnostic Radiology
Fellowship
Hospital of the University of Pennsylvania (1995), Neuroradiology

Research Interest

  • Advanced Neuroimaging Applications
  • Neuroimaging Analysis Pipelines
  • Resting State Magnetoencephalography (MEG) Analyses
  • Sports-Related Mild Traumatic Brain Injury

Publications

Featured Publications LegendFeatured Publications

Cerebral blood flow quantification in swine using pseudo-continuous arterial spin labeling.
Johnston ME, Zheng Z, Maldjian JA, Whitlow CT, Morykwas MJ, Jung Y J Magn Reson Imaging 2013 Nov 38 5 1111-8
Cerebral white matter hyperintensity in African Americans and European Americans with type 2 diabetes.
Divers J, Hugenschmidt C, Sink KM, Williamson JD, Ge Y, Smith SC, Bowden DW, Whitlow CT, Lyders E, Maldjian JA, Freedman BI J Stroke Cerebrovasc Dis 2013 Oct 22 7 e46-52
Clinical applications of arterial spin labeling.
Watts JM, Whitlow CT, Maldjian JA NMR Biomed 2013 Aug 26 8 892-900
Motor vehicle crash-related subdural hematoma from real-world head impact data.
Urban JE, Whitlow CT, Edgerton CA, Powers AK, Maldjian JA, Stitzel JD J. Neurotrauma 2012 Dec 29 18 2774-81
Brain perfusion imaging: How does it work and what should I use?
McGehee BE, Pollock JM, Maldjian JA J Magn Reson Imaging 2012 Dec 36 6 1257-72
Whither the hippocampus? FDG-PET hippocampal hypometabolism in Alzheimer disease revisited.
Maldjian JA, Whitlow CT AJNR Am J Neuroradiol 2012 Nov 33 10 1975-82
A method to investigate the size and shape variation of the lateral ventricles with age.
Urban JE, Maldjian JA, Whitlow CT, Stitzel JD Biomed Sci Instrum 2012 48 447-53
Combining graph and machine learning methods to analyze differences in functional connectivity across sex.
Casanova R, Whitlow CT, Wagner B, Espeland MA, Maldjian JA Open Neuroimag J 2012 6 1-9
Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes.
Casanova R, Espeland MA, Goveas JS, Davatzikos C, Gaussoin SA, Maldjian JA, Brunner RL, Kuller LH, Johnson KC, Mysiw WJ, Wagner B, Resnick SM Magn Reson Imaging 2011 May 29 4 546-53
Response of arteriovenous malformations to gamma knife therapy evaluated with pulsed arterial spin-labeling MRI perfusion.
Pollock JM, Whitlow CT, Simonds J, Stevens EA, Kraft RA, Burdette JH, Maldjian JA AJR Am J Roentgenol 2011 Jan 196 1 15-22

Honors & Awards

  • Best Paper Trainee (Co-Author)
    American Society of Neuroradiology (2014)
  • Graduate Design and Research Award (Co-Author)
    Biomedical Engineering Society (2014)
  • Best Poster (Co-Author)
    American Society of Functional Neuroradiology (2012)
  • Outstanding Teacher
    International Society for Magnetic Resonance in Medicine (2009)
  • Derek Harwood-Nash Award (co-author), Outstanding Presentation Award in Pediatric Neuroradiology
    American Society of Neuroradiology (2008)
  • Best Doctors in America
    U.S. News & World Report (2005-2015)
  • Rennick Award (co-author)
    International Neuropsychological Society (2001)
  • American Roentgen Ray Society Scholar
    American Roentgen Ray Society (1999)
  • Sanofi-Winthrop Fellow in Neuroradiology
    Hospital of the University of Pennsylvania (1993)
  • Chief Resident, Department of Radiology
    Mount Sinai Medical Center, New York (1992)
  • Magna Cum Laude, Biochemistry
    Princeton University (1984)

Professional Associations/Affiliations

  • American Board of Radiology
  • American College of Radiology
  • American Society for Functional Neuroradiology
  • American Society of Neuroradiology
  • International Society for Magnetic Resonance in Medicine
  • Radiological Society of North America