Biography

Dr. Chahrour received her undergraduate degree in Biology from the American University of Beirut prior to attending the University of North Texas for a masters degree in Forensic Genetics. She obtained her Ph.D. in Molecular and Human Genetics from Baylor College of Medicine where she studied molecular mechanisms underlying Rett syndrome.

She joined Harvard Medical school and Boston Children's Hospital as a postdoctoral fellow and later as an instructor in the Division of Genetics and Genomics, where she focused on identifying genetic causes of autism spectrum disorder.

Dr. Chahrour joined the faculty at the McDermott Center for Human Genetics and the departments of Neuroscience and Psychiatry in 2015.

Research Interest

  • Autism spectrum disorder
  • Genetics of neurodevelopmental disorders
  • Genomics and neurogenetics
  • Ubiquitin proteasome pathway

Publications

Featured Publications LegendFeatured Publications

Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice
Heckman LD, Chahrour MH, Zoghbi HY eLife 2014 3 e02676
Ube3a/E6AP is involved in a subset of MeCP2 functions
Kim S, Chahrour M, Ben-Shachar S, Lim J Biochemical and biophysical research communications 2013 437 1 67-73
The autism sequencing consortium: large-scale, high-throughput sequencing in autism spectrum disorders
Buxbaum JD, Daly MJ, Devlin B, Lehner T, Roeder K, State MW; Autism Sequencing Consortium Neuron 2012 76 6 1052-1056
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HY Nature 2010 468 7321 263-269
Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus
Ben-Shachar S, Chahrour M, Thaller C, Shaw CA, Zoghbi HY Human molecular genetics 2009 18 13 2431-2442
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, FariƱas I, Karsenty G, Grosschedl R Cell 2006 125 5 971-986
Novel sequence variants in the TMIE gene in families with autosomal recessive nonsyndromic hearing impairment
Santos RL, El-Shanti H, Sikandar S, Lee K, Bhatti A, Yan K, Chahrour MH, McArthur N, Pham TL, Mahasneh AA, Ahmad W, Leal SM Journal of molecular medicine 2006 84 3 226-231
A novel autosomal recessive non-syndromic hearing impairment locus (DFNB47) maps to chromosome 2p25.1-p24.3
Hassan MJ, Santos RL, Rafiq MA, Chahrour MH, Pham TL, Wajid M, Hijab N, Wambangco M, Lee K, Ansar M, Yan K, Ahmad W, Leal SM Human genetics 2006 118 5 605-610
Novel sequence variants in the TMC1 gene in Pakistani families with autosomal recessive hearing impairment
Santos RL, Wajid M, Khan MN, McArthur N, Pham TL, Bhatti A, Lee K, Irshad S, Mir A, Yan K, Chahrour MH, Ansar M, Ahmad W, Leal SM Human mutation 2005 26 4 396
A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3
Aslam M, Wajid M, Chahrour MH, Ansar M, Haque S, Pham TL, Santos RP, Yan K, Ahmad W, Leal SM American journal of medical genetics. Part A 2005 133A 1 18-22

Books

Featured Books Legend Featured Books

Autism spectrum disorders. In Genomic and personalized medicine

Yu TW, Coulter ME, Chahrour MH, Walsh CA (2012). Oxford, Academic Press

Professional Associations/Affiliations

  • International Society for Autism Research (2015)
  • International Rett Syndrome Foundation (2006-2009)
  • Society for Neuroscience (2006)
  • American Society of Human Genetics (2004)
  • Sigma Xi, The Scientific Research Society (2004)
  • American Academy of Forensic Sciences (2001-2004)
  • Association of Forensic DNA Analysts and Administrators (2001-2003)