Dr. Hon received his bachelor’s in Computer Science and Molecular & Cell Biology at UC Berkeley. He then completed his PhD in Bioinformatics and Systems Biology at UC San Diego, where he worked with Dr. Bing Ren to pioneer the use of epigenetic signatures to study transcriptional enhancers in mammalian development and disease. In 2015, Dr. Hon joined UT Southwestern as an assistant professor. He is a CPRIT scholar, and a recipient of the NIH Director’s New Innovator Award.
The Hon lab seeks to decode the complexity of the human genome to gain fundamental insights about how it works. Towards this goal, two directions of the Dr. Hon’s lab are: 1) to understand the molecular basis of cell state for applications in regenerative medicine and 2) to elucidate how non-coding variants contribute to breast cancer risk. The lab takes a systems biology approach: developing integrative techniques at the interface of gene regulation, epigenetics, genome engineering, single-cell genomics, and bioinformatics.
- Cell state engineering
- Gene regulation in development and disease
- Non-coding genome function
- Single-cell functional genomics
- Global Analysis of Enhancer Targets Reveals Convergent Enhancer-Driven Regulatory Modules.
- Xie S, Armendariz D, Zhou P, Duan J, Hon GC, Cell Rep 2019 11 29 9 2570-2578.e5
- Rational Reprogramming of Cellular States by Combinatorial Perturbation.
- Duan J, Li B, Bhakta M, Xie S, Zhou P, Munshi NV, Hon GC, Cell Rep 2019 Jun 27 12 3486-3499.e6
- Multiplexed Engineering and Analysis of Combinatorial Enhancer Activity in Single Cells.
- Xie S, Duan J, Li B, Zhou P, Hon GC Mol. Cell 2017 Apr 66 2 285-299.e5
- Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
- Yu M, Hon GC, Szulwach KE, Song CX, Zhang L, Kim A, Li X, Dai Q, Shen Y, Park B, Min JH, Jin P, Ren B, He C Cell 2012 Jun 149 6 1368-80
- Histone modifications at human enhancers reflect global cell-type-specific gene expression.
- Heintzman ND, Hon GC, Hawkins RD, Kheradpour P, Stark A, Harp LF, Ye Z, Lee LK, Stuart RK, Ching CW, Ching KA, Antosiewicz-Bourget JE, Liu H, Zhang X, Green RD, Lobanenkov VV, Stewart R, Thomson JA, Crawford GE, Kellis M, Ren B Nature 2009 May 459 7243 108-12
- Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition.
- Bhattacharyya S, Duan J, Wang L, Li B, Bhakta M, Fernandez-Perez A, Hon GC, Munshi NV Sci Rep 2019 Feb 9 1 2106
- Experimental and Computational Approaches for Single-Cell Enhancer Perturbation Assay.
- Xie S, Hon GC Methods Mol. Biol. 2019 1935 203-221
- A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra.
- Henry GH, Malewska A, Joseph DB, Malladi VS, Lee J, Torrealba J, Mauck RJ, Gahan JC, Raj GV, Roehrborn CG, Hon GC, MacConmara MP, Reese JC, Hutchinson RC, Vezina CM, Strand DW Cell Rep 2018 Dec 25 12 3530-3542.e5
- Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice.
- Hepler C, Shan B, Zhang Q, Henry GH, Shao M, Vishvanath L, Ghaben AL, Mobley AB, Strand D, Hon GC, Gupta RK Elife 2018 09 7
- Tet-Assisted Bisulfite Sequencing (TAB-seq).
- Yu M, Han D, Hon GC, He C Methods Mol. Biol. 2018 1708 645-663
Honors & Awards
- NIH Director's New Innovator Award
- Cancer Prevention Research Institute of Texas First Time Faculty Recruitment Award