Stanislaw Deja, Ph.D. Assistant Professor School Medical School Department Center for Human Nutrition | Biochemistry Biography Download Curriculum Vitae Stanislaw Deja obtained his B.Eng and M.Sc. degrees from the Wroclaw University of Technology. He completed a joint doctoral program carried by Opole University and Wroclaw University of Technology in Poland (2010-2014) and postdoctoral fellowship at UT Southwestern Medical Center (2014-2017). During his doctorate, he led the development of one the first NMR based metabolomics platforms in Poland and successfully implemented it for human studies. Following graduation, he moved to US and completed a Robert A. Welch foundation postdoctoral fellowship in the Advanced Imaging Research Center at UT Southwestern Medical Center, where he worked on development and validation of combined NMR and MS approaches for metabolic flux quantification. In particular he specializes in use of stable isotope labeled metabolites for metabolic tracing experiments in vivo and ex vivo and mathematical modeling of metabolic networks. Education Graduate School (2014), Chemistry Research Interest Energetic regulation of liver metabolism Exercise physiology In Vivo and Ex Vivo utilization of stable isotope tracers Metabolic Flux Analysis (MFA) Neuro-hepatology NMR and MS metabolomics Publications Featured Publications Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability. Deja S, Fletcher JA, Kim CW, Kucejova B, Fu X, Mizerska M, Villegas M, Pudelko-Malik N, Browder N, Inigo-Vollmer M, Menezes CJ, Mishra P, Berglund ED, Browning JD, Thyfault JP, Young JD, Horton JD, Burgess SC, Cell Metab 2024 Mar Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice. Yiew NKH, Deja S, Ferguson D, Cho K, Jarasvaraparn C, Jacome-Sosa M, Lutkewitte AJ, Mukherjee S, Fu X, Singer JM, Patti GJ, Burgess SC, Finck BN, iScience 2023 Nov 26 11 108196 Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization. Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS, Kim DS, Sun X, An YA, Field BC, Lee C, Matsuo EI, Mizerska M, Sanjana I, Fujiwara N, Kusminski CM, Gordillo R, Gautron L, Marciano DK, Hu MC, Burgess SC, Susztak K, Moe OW, Scherer PE, Nat Commun 2023 Oct 14 1 6531 Krebs takes a turn at cell differentiation. Deja S, Crawford PA, Burgess SC, Cell Metab 2022 May 34 5 658-660 INCA 2.0: A tool for integrated, dynamic modeling of NMR- and MS-based isotopomer measurements and rigorous metabolic flux analysis. Rahim M, Ragavan M, Deja S, Merritt ME, Burgess SC, Young JD, Metab Eng 2021 Dec Ins and Outs of the TCA Cycle: The Central Role of Anaplerosis. Inigo M, Deja S, Burgess SC, Annu Rev Nutr 2021 Jul In Vivo Estimation of Ketogenesis Using Metabolic Flux Analysis-Technical Aspects and Model Interpretation. Deja S, Kucejova B, Fu X, Browning JD, Young JD, Burgess S, Metabolites 2021 Apr 11 5 Simultaneous tracers and a unified model of positional and mass isotopomers for quantification of metabolic flux in liver. Deja S, Fu X, Fletcher JA, Kucejova B, Browning JD, Young JD, Burgess SC, Metab. Eng. 2019 Dec Targeted Determination of Tissue Energy Status by LC-MS/MS. Fu X, Deja S, Kucejova B, Duarte JAG, McDonald JG, Burgess SC, Anal. Chem. 2019 Apr Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, Cell Metab. 2019 Apr Results 1-10 of 35 1 2 3 4 Next Last Honors & Awards UT Southwestern Science Ambassador (2024) K01 Career Development Award (2022) Outstanding Reviewer Award of Journal Metabolites (2020) Professional Associations/Affiliations American Diabetes Association (ADA) (2015) Metabolomics Society (2012)
