Wenxin Zheng, M.D.
Professor

Wenxin Zheng, M.D., Tenured Professor of Pathology, Obstetrics and Gynecology, American board certified pathologist, graduated from Shanghai Medical College Fudan University and trained at Columbia University, Cornell University, and Brown University Medical Centers in anatomic pathology and gynecologic pathology, Selected by US News and World Report multiple times as one of America's top pathologists, Dr. Zheng is an internationally recognized gynecologic pathologist with outstanding expertise in every aspect of gynecologic pathology.  Dr. Zheng’s main research contributions include endometrial serous carcinogenesis and precancerous lesion endometrial glandular dysplasia, cell origin of low-grade ovarian serous carcinoma, hormonal etiology of ovarian epithelial cancers, and tubal contribution of ovarian endometriosis and its associated ovarian cancers.  In addition to these, Dr. Zheng has created a novel approach called "One Stop Cervical Care (OSCC)" to diagnose and treat cervical precancers. 

Medical School

Shanghai Medical College of Fudan University (1982)

Internship

Hospital of Obstetrics and Gynecology (1983), Obstetrics & Gynecology

Residency

Hospital of Obstetrics and Gynecology (1986), Obstetrics & Gynecology

Fellowship

Columbia University Medical Center (1989), Molecular Reproduction

Residency

Cornell New York Presbyterian Hospital (1995), Pathology

Fellowship

Brown University Woman & Infant Hospital (1996), Gynecologic Pathology

• Biomarkers to aid the diagnosis of gynecologic cancers
• Cervical cancer: suitable model of cervical cancer screening, effective intervention, and prevention in developing countries.
• Endometrial serous carcinoma: carcinogenesis, early detection and prevention
• Ovarian cancer early detection and prevention
• Tubal origin of ovarian endometriosis and its related cancer development
• Tubal secretory cell biology

Featured Publications

Specific Biomarker Expression Patterns in the Diagnosis of Residual and Recurrent Endometrial Precancers After Progestin Treatment: A Longitudinal Study.

Chen H, Lucas E, Strickland AL, Carrick K, Gwin K, Castrillon DH, Rivera-Colon G, Niu S, Molberg KH, Zheng W, Am. J. Surg. Pathol. 2020 Oct 44 10 1429-1439

De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection.

Beshnova D, Ye J, Onabolu O, Moon B, Zheng W, Fu YX, Brugarolas J, Lea J, Li B, Sci Transl Med 2020 Aug 12 557

Cervical Adenocarcinoma: Histopathologic Features From Biopsies to Predict Tumor Behavior.

Rivera-Colon G, Chen H, Niu S, Lucas E, Holloway S, Carrick K, Gwin K, Lea J, Zheng W, Am. J. Surg. Pathol. 2020 Feb 44 2 247-254

Loss of tubal ciliated cells as a risk for "ovarian" or pelvic serous carcinoma.

Tao T, Lin W, Wang Y, Zhang J, Chambers SK, Li B, Lea J, Wang Y, Wang Y, Zheng W, Am J Cancer Res 2020 10 11 3815-3827

Metformin sensitizes endometrial cancer cells to progestin by targeting TET1 to downregulate glyoxalase I expression.

Jiang Y, Chen X, Wei Y, Feng Y, Zheng W, Zhang Z, Biomed. Pharmacother. 2019 May 113 108712

Effect of Progestin Usage on the Interpretation of Cervical High-grade Squamous Intraepithelial Lesion.

Wang Y, Chen H, Jiang Q, Luo R, Zhou P, Wang Y, Zhao R, Fadare O, Zheng W, Am. J. Surg. Pathol. 2019 Apr

Tubal Origin of "Ovarian" Low-Grade Serous Carcinoma: A Gene Expression Profile Study.

Wang Y, Hong S, Mu J, Wang Y, Lea J, Kong B, Zheng W, J Oncol 2019 2019 8659754

Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism.

Bai M, Yang L, Liao H, Liang X, Xie B, Xiong J, Tao X, Chen X, Cheng Y, Chen X, Feng Y, Zhang Z, Zheng W Oncogene 2018 Jun

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway.

Wang Y, Wang Y, Zhang Z, Park JY, Guo D, Liao H, Yi X, Zheng Y, Zhang D, Chambers SK, Zheng W Oncotarget 2016 Jan

Fallopian tube secretory cell expansion: a sensitive biomarker for ovarian serous carcinogenesis.

Wang Y, Li L, Wang Y, Tang SN, Zheng W Am J Transl Res 2016 8 1 230-8

 Featured Books

Many chapters as leading or co-authors. In Gynecologic and Obstetrics Pathology

Wenxin Zheng et al., (Ed.) (2013). Beijing,China, Science Press

Endometrial Carcinogenesis. In Gynecologic and Obstetric Pathology, Volume 1

Wenxin Zheng Oluwole Fadare Charles Matthew Quick Danhua Shen Donghui Guo (Ed.) (2019). Singapore, Springer

Germ Cell Tumors and Mixed Germ Cell-Sex Cord-Stromal Tumors of the Ovary. In Gynecologic and Obstetric Pathology, Volume 2

Wenxin Zheng Oluwole Fadare Charles Matthew Quick Danhua Shen Donghui Guo (Ed.) (2019). Singapore, Springer

Diagnostic Endometrial Pathology

Yee Khong, Annie Chueng, Wenxin Zheng (Ed.) (2019). Autralia, Taylor & Francis