Wenxin Zheng, M.D.

Wenxin Zheng, M.D., Tenured Professor of Pathology, Tenured Professor of Obstetrics and Gynecology, Mark and Jane Gibson Distinguished Professor in Cancer Research, American board certified pathologist, graduated from Shanghai Medical College Fudan University and trained at Columbia University, Cornell University, and Brown University Medical Centers in anatomic pathology and gynecologic pathology, Selected by US News and World Report multiple times as one of America's top pathologists, Dr. Zheng is an internationally recognized gynecologic pathologist with outstanding expertise in every aspect of gynecologic pathology.  Dr. Zheng’s main research contributions include endometrial serous carcinogenesis and precancerous lesion diagnosis, cell origin of low-grade ovarian serous carcinoma, hormonal etiology of ovarian epithelial cancers, and tubal contribution of ovarian endometriosis and its associated ovarian cancers.  In addition to these, Dr. Zheng has created a novel approach called "One Stop Cervical Care (OSCC)" to diagnose and treat cervical precancers. 

Medical School

Shanghai Medical College of Fudan University (1982)

Internship

Hospital of Obstetrics and Gynecology (1983), Obstetrics & Gynecology

Residency

Hospital of Obstetrics and Gynecology (1986), Obstetrics & Gynecology

Fellowship

Columbia University Medical Center (1989), Molecular Reproduction

Residency

Cornell New York Presbyterian Hospital (1995), Pathology

Fellowship

Brown University Woman & Infant Hospital (1996), Gynecologic Pathology

• Biomarkers to aid the diagnosis of gynecologic cancers
• Cervical cancer: suitable model of cervical cancer screening, effective intervention, and prevention in developing countries.
• Endometrial serous carcinoma: carcinogenesis, early detection and prevention
• Ovarian cancer early detection and prevention
• Tubal origin of ovarian endometriosis and its related cancer development
• Tubal secretory and ciliated cell biology and their roles in ovarian serous carcinogenesis

Featured Publications

Morules But Not Squamous Differentiation are a Reliable Indicator of CTNNB1 (ß-catenin) Mutations in Endometrial Carcinoma and Precancers

Niu S, Lucas E, Molberg K, Strickland A, Wang Y, Carrick K, Rivera-Colon G, Gwin K, SoRelle JA, Castrillon DH, Zheng W, Chen H, Am J Surg Pathol 2022 Jul

The Prognostic Values of HPV Genotypes and Tumor PD-L1 Expression in Patients With HPV-associated Endocervical Adenocarcinoma.

Zhou F, Chen H, Li M, Strickland AL, Zheng W, Zhang X, Am J Surg Pathol 2022 03 46 3 300-308

Endometrial stromal tumors: Diagnostic updates and challenges.

Niu S, Zheng W, Semin Diagn Pathol 2022 Jan

The IVF-generated human embryonic microenvironment reverses progestin resistance in endometrial cancer cells by inducing cancer stem cell differentiation.

Sun D, Qin Z, Xu Y, Xiao Q, Xu Y, Bai M, Li W, Liu Y, Zheng W, Zhang Z, Cancer Lett 2021 Nov

Tumoral Morphologic Features From Cervical Biopsies That Are Predictive of a Negligible Risk for Nodal Metastasis and Tumor Recurrence in Usual-type Cervical Adenocarcinomas: A Multi-institutional Study.

Wang Y, Chang RJ, Luo RZ, Yu J, Zhang X, Yang X, Quddus MR, Li L, Yang W, Liu A, Jiang Q, Zhao R, Zhu H, Zhou F, Wang Y, Sheng X, Liu LL, Wen YL, Banet N, Sung CJ, Qi Y, Bi R, Li M, Wang Y, Li J, Lin W, Wang Y, Rivera G, Chen H, Holloway SB, Fadare O, Liu J, Wang J, Lea J, Kong B, Zheng W, Am J Surg Pathol 2021 Nov

High-grade endometrial carcinomas: Morphologic spectrum and molecular classification.

Zhang C, Zheng W, Semin Diagn Pathol 2021 Nov

Navigating through perplex morphologic changes after exogenous hormone usage.

Chang RJ, Rivera-Colon G, Chen H, Niu S, Carrick K, Lucas E, Gwin K, Zheng W, Semin Diagn Pathol 2021 Oct

Reliable Identification of Endometrial Precancers Through Combined Pax2, ß-Catenin, and Pten Immunohistochemistry

Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, Cuevas IC, Sahoo SS, Li HD, Zhang S, Zheng W, Lucas E, Castrillon DH, Am J Surg Pathol 2021 Sep

Tumor Necrotic Debris and High Nuclear Grade: Newly Identified High-risk Factors for Early-stage Endocervical Adenocarcinoma.

Holloway SB, Colon GR, Zheng W, Lea JS, Am J Clin Oncol 2021 04 44 4 162-168

Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors.

Aguilar M, Zhang H, Zhang M, Cantarell B, Sahoo SS, Li HD, Cuevas IC, Lea J, Miller DS, Chen H, Zheng W, Gagan J, Lucas E, Castrillon DH, J Pathol 2021 Jan

 Featured Books

Many chapters as leading or co-authors. In Gynecologic and Obstetrics Pathology

Wenxin Zheng et al., (Ed.) (2013). Beijing,China, Science Press

Author for multiple chapters in the book. In Gynecologic and Obstetric Pathology, Volume 1

Wenxin Zheng Oluwole Fadare Charles Matthew Quick Danhua Shen Donghui Guo (Ed.) (2019). Singapore, Springer

Author for multiple chapters in the book. In Gynecologic and Obstetric Pathology, Volume 2

Wenxin Zheng Oluwole Fadare Charles Matthew Quick Danhua Shen Donghui Guo (Ed.) (2019). Singapore, Springer

Diagnostic Endometrial Pathology

Yee Khong, Annie Chueng, Wenxin Zheng (Ed.) (2019). Autralia, Taylor & Francis

Author for multiple chapters in the book. In Gynecologic and Obstetric Pathology, volume 1 In Mandarin

Wenxin Zheng, Danhua Shen, Donghui Guo, Oluwole Fadare, Charles Matthew Quick (Ed.) (2021). Beijing, Science Press

Author for multiple chapters in the book. In Gynecologic and Obstetric Pathology, volume 2 In Mandarin

Wenxin Zheng, Danhua Shen, Donghui Guo, Oluwole Fadare, Charles Matthew Quick (Ed.) (2021). Beijing, Science Press