Justin Fletcher, Ph.D.

Graduate School

Uni of Missouri - Columbia (2014), Exercise Physiology

• Effects of alcohol consumption on heart health/function
• Exercise Physiology
• Liver Disease (alcoholic, non-alcoholic)
• Metabolism
• Pathophysiology of Obesity
• Stable Isotope Tracers

Featured Publications

Simultaneous tracers and a unified model of positional and mass isotopomers for quantification of metabolic flux in liver.

Deja S, Fu X, Fletcher JA, Kucejova B, Browning JD, Young JD, Burgess SC, Metab. Eng. 2019 Dec

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.

Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, Cell Metab. 2019 Jun 29 6 1291-1305.e8

Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver.

Fletcher JA, Deja S, Satapati S, Fu X, Burgess SC, Browning JD, JCI Insight 2019 Apr 5

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC, J. Clin. Invest. 2016 Apr 126 4 1605

Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver.

Fu X, Fletcher JA, Deja S, Inigo-Vollmer M, Burgess SC, Browning JD, J Clin Invest 2023 May 133 9

Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor ? coactivator-1a-deficient mice.

Fletcher JA, Linden MA, Sheldon RD, Meers GM, Morris EM, Butterfield A, Perfield JW, Rector RS, Thyfault JP, Exp. Physiol. 2018 03 103 3 408-418

Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21.

Porter JW, Rowles JL, Fletcher JA, Zidon TM, Winn NC, McCabe LT, Park YM, Perfield JW, Thyfault JP, Rector RS, Padilla J, Vieira-Potter VJ, J. Endocrinol. 2017 Nov 235 2 97-109

Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis.

Morris EM, McCoin CS, Allen JA, Gastecki ML, Koch LG, Britton SL, Fletcher JA, Fu X, Ding WX, Burgess SC, Rector RS, Thyfault JP, J. Physiol. (Lond.) 2017 07 595 14 4909-4926

Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis.

Morris EM, Meers GM, Koch LG, Britton SL, Fletcher JA, Fu X, Shankar K, Burgess SC, Ibdah JA, Rector RS, Thyfault JP, Am. J. Physiol. Endocrinol. Metab. 2016 10 311 4 E749-E760

A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats.

Linden MA, Fletcher JA, Meers GM, Thyfault JP, Laughlin MH, Rector RS, Am. J. Physiol. Gastrointest. Liver Physiol. 2016 09 311 3 G387-95