Justin Fletcher, Ph.D. Assistant Professor School School of Health Professions Department Clinical Nutrition Education Graduate School Uni of Missouri - Columbia (2014), Exercise Physiology Research Interest Effects of alcohol consumption on heart health/function Exercise Physiology Liver Disease (alcoholic, non-alcoholic) Metabolism Pathophysiology of Obesity Stable Isotope Tracers Publications Featured Publications Simultaneous tracers and a unified model of positional and mass isotopomers for quantification of metabolic flux in liver. Deja S, Fu X, Fletcher JA, Kucejova B, Browning JD, Young JD, Burgess SC, Metab. Eng. 2019 Dec Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, Cell Metab. 2019 Jun 29 6 1291-1305.e8 Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver. Fletcher JA, Deja S, Satapati S, Fu X, Burgess SC, Browning JD, JCI Insight 2019 Apr 5 Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC, J. Clin. Invest. 2016 Apr 126 4 1605 Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability. Deja S, Fletcher JA, Kim CW, Kucejova B, Fu X, Mizerska M, Villegas M, Pudelko-Malik N, Browder N, Inigo-Vollmer M, Menezes CJ, Mishra P, Berglund ED, Browning JD, Thyfault JP, Young JD, Horton JD, Burgess SC, Cell Metab 2024 Mar Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver. Fu X, Fletcher JA, Deja S, Inigo-Vollmer M, Burgess SC, Browning JD, J Clin Invest 2023 May 133 9 Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids. Martino MR, Gutiérrez-Aguilar M, Yiew NKH, Lutkewitte AJ, Singer JM, McCommis KS, Ferguson D, Liss KHH, Yoshino J, Renkemeyer MK, Smith GI, Cho K, Fletcher JA, Klein S, Patti GJ, Burgess SC, Finck BN, Cell Rep 2022 Apr 39 4 110733 Hepatic TM6SF2 is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats. Luo F, Smagris E, Martin S, Vale G, McDonald JG, Fletcher JA, Burgess SC, Hobbs HH, Cohen JC, Cell Mol Gastroenterol Hepatol 2021 Dec Measurement of lipogenic flux by deuterium resolved mass spectrometry. Fu X, Deja S, Fletcher JA, Anderson NN, Mizerska M, Vale G, Browning JD, Horton JD, McDonald JG, Mitsche MA, Burgess SC, Nat Commun 2021 06 12 1 3756 Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor ? coactivator-1a-deficient mice. Fletcher JA, Linden MA, Sheldon RD, Meers GM, Morris EM, Butterfield A, Perfield JW, Rector RS, Thyfault JP, Exp. Physiol. 2018 03 103 3 408-418 Results 1-10 of 26 1 2 3 Next Last
