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Trung Nguyen, M.D.,  Ph.D.

Trung Nguyen, M.D., Ph.D.

Titles and Appointments

Associate Professor

School
Medical School
Department
Neurology

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For more information on the doctor and patient care, please visit the clinical profile.

  • Biography

    Joined UT Southwestern: 2016

    Clinical Interests: Trung P. Nguyen, M.D., Ph.D. specializes in disorders of cognition and dementias such as Alzheimer’s disease and dementia with Lewy bodies.

    Research: Dr. Nguyen’s research focus is on neurodegenerative diseases and dementias. He is actively involved in observational and interventional clinical trials for Alzheimer’s disease.  He has also received research funding from the Texas Alzheimer’s Research and Care Consortium and the National Institute on Aging to investigate the pathologic mechanisms underlying Alzheimer’s disease and dementia with Lewy bodies.

    Background: Dr. Nguyen earned his M.D. and Ph.D. in neuroscience from the University of Texas Medical Branch at Galveston.  He then completed his residency in neurology at Emory University in Atlanta, GA.  He returned to Texas to complete his fellowship in behavioral neurology and neuropsychiatry at UT Southwestern Medical Center, and subsequently accepted a faculty position here.

  • Education
    Medical School
    UT Medical Branch at Galveston (2010)
    Other Post Graduate Training
    The University of Texas Medical Branch at Galveston (2010)
    Internship
    Emory University School of Medicine (2011), Internal Medicine
    Residency
    Emory University School of Medicine (2014), Neurology
    Fellowship
    UT Southwestern Medical Center (2016), Behavioral Neurology & Dementia
  • Research Interest
    • Alzheimer's disease
    • Dementia with Lewy bodies
    • Neurodegenerative diseases
  • Publications
    Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study
    Author Collaboration Ft, Huang LY, Tan CC, Xu W, Tan L, Fernandez D, Ong E, Stark S, Catalinotto D, Scherer K, Au YH, Nudelman KN, Faber KM, Reyes D, Ward C, Kantarci K, Senjem M, Gunter J, Borowski B, Zmuda M, Butters M, Bickford D, Nelson C, Donohue M, Drake E, Jimenez-Maggiora G, Tinklenberg J, Rosen A, Lane B, White JD, Coleman J, Chao S, Taylor JL, Yesavage J, Li G, Petrie EC, Peskind ER, Rosen H, Villena T, Martinez W, Sadowsky C, Witbracht M, Sosa E, Yanez B, Reist C, Kelley B, Kerwin D, Hajjar I, Quiceno M, Mathews D, Nguyen T Translational psychiatry 2025 Dec 15
    Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease
    Author Collaboration ob, Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, da Fonseca EL, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Ikeuchi T, Iqbal T, Pathak O, Valladares O, Reyes-Dumeyer D, Kuzma AB, Abner E, Adams LD, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Bertelson J, Huebinger RM, Hynan LS, Nguyen TP, Quiceno M, Reisch JS, Rosenberg RN, Williams B Genome biology 2025 Dec 26
    Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study
    Author Collaboration Ft, Huang LY, Tan CC, Xu W, Tan L, Fernandez D, Ong E, Stark S, Catalinotto D, Scherer K, Au YH, Nudelman KN, Faber KM, Reyes D, Ward C, Kantarci K, Senjem M, Gunter J, Borowski B, Zmuda M, Butters M, Bickford D, Nelson C, Donohue M, Drake E, Jimenez-Maggiora G, Tinklenberg J, Rosen A, Lane B, White JD, Coleman J, Chao S, Taylor JL, Yesavage J, Li G, Petrie EC, Peskind ER, Rosen H, Villena T, Martinez W, Sadowsky C, Witbracht M, Sosa E, Yanez B, Reist C, Kelley B, Kerwin D, Hajjar I, Quiceno M, Mathews D, Nguyen TP Translational psychiatry 2025 Dec 15
    The Clinical Value of NeuroQuant Hippocampal Volumes and Hippocampal Occupancy Scores in an Academic Medical Center Memory Clinic
    Schaffert J, Goette W, Nguyen T, Khera A, Ruchinskas R Cognitive and Behavioral Neurology 2025 May 38 43-49
    High definition transcranial direct current stimulation as an intervention for cognitive deficits in Alzheimer's dementia: A randomized controlled trial
    LoBue C, Chiang HS, Salter A, McClintock S, Nguyen TP, Logan R, Smernoff E, Pandya S, Hart J The journal of prevention of Alzheimer's disease 2025 Feb 12 100023
    High-definition brain stimulation targeting separate regions leads to differential word retrieval outcomes in patients with primary progressive aphasia: a pilot study
    Dugas CS, Chiang HS, Devora P, Lucas-Mendoza K, Abasi C, Adhikari A, Nguyen T, Frolov A, Kelley BJ, LoBue C, Mudar RA, Hart J Frontiers in Neurology 2025 16
    Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment
    Author Collaboration TA, Tuena C, Maestri S, Serino S, Pedroli E, Stramba-Badiale M, Riva G, Silbert LC, Lind B, Crissey R, Kaye JA, Carter R, Dolen S, Quinn J, Schneider LS, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann BM, Brewer J, Fleisher A, Vanderswag H, Ziolkowski J, Heidebrink JL, Zbizek-Nulph L, Lord JL, Albers CS, Petersen R, Mason SS, Knopman D, Johnson K, Villanueva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass JS, Doody RS, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig LS, Mintz A, Kelley B, Nguyen T, Mathews D, Quiceno M, Hajjar I, Kerwin D BMC Geriatrics 2023 Dec 23
    Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank
    Author Collaboration TA, Azevedo T, Bethlehem RA, Whiteside DJ, Swaddiwudhipong N, Rowe JB, Lió P, Rittman T, Li G, Petrie EC, Peskind ER, Villena T, Martinez W, Sadowsky C, Lee A, Ravdin L, Lin M, Chiang G, Relkin N, Santulli RB, Hynes ML, Seltzer M, Flashman LA, Anderson K, Blank K, Pearlson GD, Kittur S, Correia S, Malloy P, Salloway S, Potkin S, Newhouse P, Garcia A, Shi J, Masdeu J, Wiliams A, Mintzer J, O’Connelll A, Mintz A, Munic D, Bernick C, Ritter A, Drake JD, Daiello LA, Tremont G, Drake J, Kelley B, Kerwin D, Hajjar I, Quiceno M, Nguyen T Communications Medicine 2023 Dec 3
    HBS-1.2: Lightweight Socially Assistive Robot with 6-Ply Twisted Coiled Polymer Muscle-Actuated Hand
    Singh AP, Palani D, Ahmed O, Matharu PS, Linn T, Nguyen T, Tadesse Y Actuators 2023 Aug 12
    Regional Neuroanatomic Effects on Brain Age Inferred Using Magnetic Resonance Imaging and Ridge Regression
    Author Collaboration AD, Massett RJ, Maher AS, Imms PE, Amgalan A, Chaudhari NN, Chowdhury NF, Irimia A, Weiner MW, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris JC, Perrin RJ, Shaw LM, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao JK, Jackson J, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Sacrey DT, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Nosheny R, Ashford M, Flenniken D, Kelley B, Nguyen T, Mathews D, Quiceno M, Hajjar I, Kerwin D Journals of Gerontology - Series A Biological Sciences and Medical Sciences 2023 Jun 78 872-881
  • Professional Associations/Affiliations
    • American Academy of Neurology (2011)