Trung Nguyen, M.D., Ph.D. Titles and Appointments Associate Professor Schools Medical School Departments Neurology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Joined UT Southwestern: 2016 Clinical Interests: Trung P. Nguyen, M.D., Ph.D. specializes in disorders of cognition and dementias such as Alzheimer’s disease and dementia with Lewy bodies. Research: Dr. Nguyen’s research focus is on neurodegenerative diseases and dementias. He is actively involved in observational and interventional clinical trials for Alzheimer’s disease. He has also received research funding from the Texas Alzheimer’s Research and Care Consortium and the National Institute on Aging to investigate the pathologic mechanisms underlying Alzheimer’s disease and dementia with Lewy bodies. Background: Dr. Nguyen earned his M.D. and Ph.D. in neuroscience from the University of Texas Medical Branch at Galveston. He then completed his residency in neurology at Emory University in Atlanta, GA. He returned to Texas to complete his fellowship in behavioral neurology and neuropsychiatry at UT Southwestern Medical Center, and subsequently accepted a faculty position here. Education Other The University of Texas Medical Branch at Galveston (2010), Doctor of Philosophy Other The University of Texas Medical Branch at Galveston (2010), Doctor of Philosophy Medical Education UT Medical Branch at Galveston (2010) Internship Emory University School of Medicine (2011), Internal Medicine Residency Emory University School of Medicine (2014), Neurology Fellowship UT Southwestern Medical Center (2016), Behavioral Neurology & Dementia Research Interest Alzheimer's disease Dementia with Lewy bodies Neurodegenerative diseases Publications Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias Author Collaboration E, Author Collaboration E, Author Collaboration B, Author Collaboration A, Author Collaboration C, Author Collaboration F, Author Collaboration G, Author Collaboration G, Author Collaboration P, Lambert JC, Ramirez A, Ruiz A, Andreassen O, Sims R, Hiltunen M, Ingelsson M, Sleegers K, Sánchez-Juan P, Ghidoni R, Frikke-Schmidt R, van Duijn C, Tsolaki M, Kehoe PG, Fernandez MV, Mather K, Holstege H, Jessen F, Rossi G, Masullo C, Bossù P, Daniele A, Rainero I, Seripa D, Spallazzi M, Nacmias B, Wagner M, Borroni B, Tremolizzo L, Squassina A, Parnetti L, Solfrizzi V, Mecocci P, Arosio B, Galimberti D, Popp J, Grünblatt E, Debette S, Hanon O, Pasquier F, Dufouil C, Nicolas G, Williams B, Rosenberg RN, Reisch JS, Quiceno M, Nguyen T, Hynan LS, Cullum M, Bertelson J Nature genetics 2026 Jun 58 1214-1225 Assessing subcortical, brainstem and cerebellar metabolic patterns using [18F]FDG PET-CT imaging in dementia with Lewy bodies Author Collaboration AD, Loewenstein DS, van Grinsven M, de Pont C, Arens AI, Dautzenberg PL, van Strien AM, Sabri O, Hesse S, Rullmann M, Henssen D, Spicer K, Longmire CF, Mintzer J, Rojas YG, Sotelo V, Hu W, Jones F, Saklad A, Seshadri S, Boegel A, Hill SJ, Newhouse P, Long R, Long C, Williams A, Acree A, Brawman-Mintzer O, Reichert C, Pomara V, Hernando R, Pomara N, Acothley S, Elayan N, Slaughter ME, Garcia A, Sabbagh M, Gurung M, Le R, Masdeu J, Rosario C, Smith C, Kalowsky T, Rivera E, Okhravi H, Devine R, McColl R, Mathews D, Kelley B, Nguyen T, Pomper M European Journal of Nuclear Medicine and Molecular Imaging 2026 Sex and APOE genotype specific brain regional vulnerability to Alzheimer's Disease Author Collaboration Mo, Zeng Q, Wang M, Wang E, Zhou X, Xu P, Haroutunian V, Cai D, Zhang B, Spicer K, Longmire CF, Mintzer J, Rojas YG, Sotelo V, Hu W, Jones F, Saklad A, Seshadri S, Boegel A, Hill SJ, Newhouse P, Long R, Long C, Williams A, Acree A, Brawman-Mintzer O, Reichert C, Pomara V, Hernando R, Pomara N, Acothley S, Elayan N, Slaughter ME, Garcia A, Sabbagh M, Gurung M, Le R, Masdeu J, Rosario C, Smith C, Kalowsky T, Rivera E, Okhravi H, Devine R, Yong M, Roglaski E, Kelley B, McColl R, Mathews D, Nguyen T, Pomper M GeroScience 2026 Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegeneration Author Collaboration AD, Chaudhari NN, Vega OM, Imms P, Kawamura JM, Chowdhury NF, Jafar T, Irimia A, Spicer K, Longmire CF, Mintzer J, Rojas YG, Sotelo V, Hu W, Jones F, Saklad A, Seshadri S, Boegel A, Hill SJ, Newhouse P, Long R, Long C, Williams A, Acree A, Brawman-Mintzer O, Reichert C, Pomara V, Hernando R, Pomara N, Acothley S, Elayan N, Slaughter ME, Garcia A, Sabbagh M, Gurung M, Le R, Masdeu J, Rosario C, Smith C, Kalowsky T, Rivera E, Okhravi H, Devine R, Yong M, Roglaski E, Janavs J, McColl R, Mathews D, Kelley B, Nguyen T, Pomper M GeroScience 2026 Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease Author Collaboration ob, Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, da Fonseca EL, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Ikeuchi T, Iqbal T, Pathak O, Valladares O, Reyes-Dumeyer D, Kuzma AB, Abner E, Adams LD, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Bertelson J, Cullum M, Huebinger RM, Hynan LS, Nguyen T, Quiceno M, Reisch JS, Rosenberg RN, Williams B Genome biology 2025 Dec 26 Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study Author Collaboration Ft, Huang LY, Tan CC, Xu W, Tan L, Fernandez D, Ong E, Stark S, Catalinotto D, Scherer K, Au YH, Nudelman KN, Faber KM, Reyes D, Ward C, Kantarci K, Senjem M, Gunter J, Borowski B, Zmuda M, Butters M, Bickford D, Nelson C, Donohue M, Drake E, Jimenez-Maggiora G, Tinklenberg J, Rosen A, Lane B, White JD, Coleman J, Chao S, Taylor JL, Yesavage J, Li G, Petrie EC, Peskind ER, Rosen H, Villena T, Martinez W, Sadowsky C, Witbracht M, Sosa E, Yanez B, Reist C, Kelley B, Kerwin D, Hajjar I, Quiceno M, Mathews D, Nguyen T Translational psychiatry 2025 Dec 15 Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia (Nature Genetics, (2024), 56, 11, (2407-2421), 10.1038/s41588-024-01939-9) Author Collaboration TA, Author Collaboration TN, Shade LM, Katsumata Y, Abner EL, Aung KZ, Claas SA, Qiao Q, Heberle BA, Brandon JA, Page ML, Hohman TJ, Mukherjee S, Mayeux RP, Farrer LA, Schellenberg GD, Haines JL, Kukull WA, Nho K, Saykin AJ, Bennett DA, Schneider JA, Yasuda S, Culhane J, Ormsby K, Shibata DK, Miller Z, Oswald S, Chen YC, Mock C, Gauthreaux K, O’Connell H, Chan KC, Stephens KA, Wisniewski T, Vassar R, Van Eldik LJ, Trojanowski J, Swerdlow R, Strittmatter S, Small S, Saykin A, Sano M, Nguyen T, Hynan L, Quiceno M, Williams B, Cullum M, Rosenberg RN, Reisch JS, Adams PM, Bertelson J Nature genetics 2025 Jul 57 1788 Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia (Nature Genetics, (2024), 56, 11, (2407-2421), 10.1038/s41588-024-01939-9) Author Collaboration TA, Author Collaboration TN, Shade LM, Katsumata Y, Abner EL, Aung KZ, Claas SA, Qiao Q, Heberle BA, Brandon JA, Page ML, Hohman TJ, Mukherjee S, Mayeux RP, Farrer LA, Schellenberg GD, Haines JL, Kukull WA, Nho K, Saykin AJ, Bennett DA, Schneider JA, Yasuda S, Culhane J, Ormsby K, Shibata DK, Miller Z, Oswald S, Chen YC, Mock C, Gauthreaux K, O’Connell H, Chan KC, Stephens KA, Wisniewski T, Vassar R, Van Eldik LJ, Trojanowski J, Swerdlow R, Strittmatter S, Small S, Saykin A, Sano M, Rosenberg R, Nguyen T, Hynan L, Quiceno M, Williams B, Cullum M, Reisch JS, Adams PM, Bertelson J Nature genetics 2025 Jul 57 1791 The Clinical Value of NeuroQuant Hippocampal Volumes and Hippocampal Occupancy Scores in an Academic Medical Center Memory Clinic Schaffert J, Goette W, Nguyen T, Khera A, Ruchinskas R Cognitive and Behavioral Neurology 2025 May 38 43-49 High definition transcranial direct current stimulation as an intervention for cognitive deficits in Alzheimer's dementia: A randomized controlled trial LoBue C, Chiang HS, Salter A, McClintock S, Nguyen TP, Logan R, Smernoff E, Pandya S, Hart J Journal of Prevention of Alzheimer's Disease 2025 Feb 12 Results 1-10 of 34 1 2 3 4 Next Last Professional Associations/Affiliations American Academy of Neurology (2011)
