Biography

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Dr. Guo obtained his Ph.D. in Biochemistry at Free University of Berlin. His Ph.D. dissertation focused on the investigation of the underlying pathological mechanism of Marfan syndrome, a heritable connective tissue disorder. He proposed a completely new therapeutic strategy using monoclonal and anti-inflammatory treatment to ameliorate manifestations of aortic disease in Marfan patients. This work resulted in several peer-reviewed articles in prestigious journals such as Circulation. He received his postdoctoral training  at UCLA School of Dentistry, where he studied the role of NFk-B signaling pathways in oral squamous cell carcinoma.

In 2014, Dr. Guo joined the Department of  Neurology for his second postdoctoral training and is now an Instructor in the same department. His current research focuses on understanding the mechanism of resistance to EGFR inhibition in glioblastoma (GBM). He has identified an adaptive signaling pathway that is responsible for the resistance to EGFR inhibition in GBM  and proposed a new treatment strategy to overcome resistance to EGFR inhibition.  He also has a particular interest in oncogenic signaling  in GBM invasion and proliferation.

Dr. Guo has published over 20 peer-review articles and reviews, 14 of which are first/co-first author.  He is committed to continue transitioning his research program in a more translational direction for the novel developing therapies that may be useful in the treatment of patients with GBM. 

Research Interest

  • Glioblastoma invasion and proliferation
  • Mechanism of drug resistance in glioblastoma
  • Oncogenic signaling

Publications

Featured Publications LegendFeatured Publications

A fibrillin-1-fragment containing the elastin-binding-protein GxxPG consensus sequence upregulates matrix metalloproteinase-1: biochemical and computational analysis.
Booms P, Ney A, Barthel F, Moroy G, Counsell D, Gille C, Guo G, Pregla R, Mundlos S, Alix AJ, Robinson PN, J. Mol. Cell. Cardiol. 2006 Feb 40 2 234-46
Calcium-dependent self-association of the C-type lectin domain of versican.
Ney A, Booms P, Epple G, Mörgelin M, Guo G, Kettelgerdes G, Gessner R, Robinson PN, Int. J. Biochem. Cell Biol. 2006 Jan 38 1 23-9

Honors & Awards

  • Free University Scholarship for PhD student