Dr. Guo obtained his Ph.D. in Biochemistry at Free University of Berlin. His Ph.D. dissertation focused on the investigation of the underlying pathological mechanism of Marfan syndrome, a heritable connective tissue disorder. He proposed a completely new therapeutic strategy using monoclonal and anti-inflammatory treatment to ameliorate manifestations of aortic disease in Marfan patients. This work resulted in several peer-reviewed articles in prestigious journals such as Circulation. He received his postdoctoral training at UCLA School of Dentistry, where he studied the role of NFk-B signaling pathways in oral squamous cell carcinoma.
In 2014, Dr. Guo joined the Department of Neurology for his second postdoctoral training and is now an Instructor in the same department. His current research focuses on understanding the mechanism of resistance to EGFR inhibition in glioblastoma (GBM). He has identified an adaptive signaling pathway that is responsible for the resistance to EGFR inhibition in GBM and proposed a new treatment strategy to overcome resistance to EGFR inhibition. He also has a particular interest in oncogenic signaling in GBM invasion and proliferation.
Dr. Guo has published over 20 peer-review articles and reviews, 14 of which are first/co-first author. He is committed to continue transitioning his research program in a more translational direction for the novel developing therapies that may be useful in the treatment of patients with GBM.
- Glioblastoma invasion and proliferation
- Mechanism of drug resistance in glioblastoma
- Oncogenic signaling
- Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks.
- Chakraborty S, Li L, Puliyappadamba VT, Guo G, Hatanpaa KJ, Mickey B, Souza RF, Vo P, Herz J, Chen MR, Boothman DA, Pandita TK, Wang DH, Sen GC, Habib AA Nat Commun 2014 5 5811
- Regulation of fibrillin-1 gene expression by Sp1.
- Guo G, Rödelsperger C, Digweed M, Robinson PN, Gene 2013 Sep 527 2 448-55
- Indomethacin Prevents the Progression of Thoracic Aortic Aneurysm in Marfan Syndrome Mice.
- Guo G, Ott CE, Grünhagen J, Muñoz-García B, Pletschacher A, Kallenbach K, von Kodolitsch Y, Robinson PN, Aorta (Stamford) 2013 Jun 1 1 5-12
- Integrative analysis of genomic, functional and protein interaction data predicts long-range enhancer-target gene interactions.
- Rödelsperger C, Guo G, Kolanczyk M, Pletschacher A, Köhler S, Bauer S, Schulz MH, Robinson PN, Nucleic Acids Res. 2011 Apr 39 7 2492-502
- MicroRNAs differentially expressed in postnatal aortic development downregulate elastin via 3' UTR and coding-sequence binding sites.
- Ott CE, Grünhagen J, Jäger M, Horbelt D, Schwill S, Kallenbach K, Guo G, Manke T, Knaus P, Mundlos S, Robinson PN, PLoS ONE 2011 Jan 6 1 e16250
- Induction of macrophage chemotaxis by aortic extracts from patients with Marfan syndrome is related to elastin binding protein.
- Guo G, Gehle P, Doelken S, Martin-Ventura JL, von Kodolitsch Y, Hetzer R, Robinson PN, PLoS ONE 2011 6 5 e20138
- Quantitative analysis of TGFBR2 mutations in Marfan-syndrome-related disorders suggests a correlation between phenotypic severity and Smad signaling activity.
- Horbelt D, Guo G, Robinson PN, Knaus P, J. Cell. Sci. 2010 Dec 123 Pt 24 4340-50
- CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait.
- Türkmen S, Guo G, Garshasbi M, Hoffmann K, Alshalah AJ, Mischung C, Kuss A, Humphrey N, Mundlos S, Robinson PN, PLoS Genet. 2009 May 5 5 e1000487
- A short ultraconserved sequence drives transcription from an alternate FBN1 promoter.
- Guo G, Bauer S, Hecht J, Schulz MH, Busche A, Robinson PN, Int. J. Biochem. Cell Biol. 2008 40 4 638-50
- The molecular genetics of Marfan syndrome and related disorders.
- Robinson PN, Arteaga-Solis E, Baldock C, Collod-Béroud G, Booms P, De Paepe A, Dietz HC, Guo G, Handford PA, Judge DP, Kielty CM, Loeys B, Milewicz DM, Ney A, Ramirez F, Reinhardt DP, Tiedemann K, Whiteman P, Godfrey M, J. Med. Genet. 2006 Oct 43 10 769-87
Honors & Awards
- Free University Scholarship for PhD student