Download Curriculum Vitae

Dr. Guo obtained his Ph.D. in Biochemistry at Free University of Berlin. His Ph.D. dissertation focused on the investigation of the underlying pathological mechanism of Marfan syndrome, a heritable connective tissue disorder. He proposed a completely new therapeutic strategy using monoclonal and anti-inflammatory treatment to ameliorate manifestations of aortic disease in Marfan patients. This work resulted in several peer-reviewed articles in prestigious journals such as Circulation. He received his postdoctoral training  at UCLA School of Dentistry, where he studied the role of NFk-B signaling pathways in oral squamous cell carcinoma.

In 2014, Dr. Guo joined the Department of  Neurology for his second postdoctoral training and is now an Instructor in the same department. His current research focuses on understanding the mechanism of resistance to EGFR inhibition in glioblastoma (GBM). He has identified an adaptive signaling pathway that is responsible for the resistance to EGFR inhibition in GBM  and proposed a new treatment strategy to overcome resistance to EGFR inhibition.  He also has a particular interest in oncogenic signaling  in GBM invasion and proliferation.

Dr. Guo has published over 21 peer-review articles and reviews, 15 of which are first/co-first author.  He is committed to continue transitioning his research program in a more translational direction for the novel developing therapies that may be useful in the treatment of patients with GBM. 

Research Interest

  • Glioblastoma invasion and proliferation
  • Mechanism of drug resistance in glioblastoma
  • Oncogenic signaling


Featured Publications LegendFeatured Publications

Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids
Gong K, Guo G, Beckley NA, Yang X, Zhang Y, Gerber DE, Minna JD, Burma S, Zhao D, Akbay EA, Habib AA NC 2021 Accepted, in press
TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer.
Gong K, Guo G, Gerber DE, Gao B, Peyton M, Huang C, Minna JD, Hatanpaa KJ, Kernstine K, Cai L, Xie Y, Zhu H, Fattah FJ, Zhang S, Takahashi M, Mukherjee B, Burma S, Dowell J, Dao K, Papadimitrakopoulou VA, Olivas V, Bivona TG, Zhao D, Habib AA J. Clin. Invest. 2018 Jun 128 6 2500-2518
The Role of EGFR-Met Interactions in the Pathogenesis of Glioblastoma and Resistance to Treatment.
Guo G, Narayan RN, Horton L, Patel TR, Habib AA Curr Cancer Drug Targets 2017 17 3 297-302
Analysis of Constitutive EGFR Signaling Regulating IRF3 Transcriptional Activity in Cancer Cells.
Guo G, Gong K, Habib AA Methods Mol. Biol. 2017 1652 183-189
Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53.
Ramadoss S, Guo G, Wang CY Oncogene 2017 01 36 1 47-59
Ligand-Independent EGFR Signaling.
Guo G, Gong K, Wohlfeld B, Hatanpaa KJ, Zhao D, Habib AA Cancer Res. 2015 Aug

Honors & Awards

  • Free University Scholarship for PhD student