S M Udden, Ph.D.

Dr. Udden is an immuno-oncology scientist with expertise in DNA damage response, mucosal immunity, host pathogen interaction, tumor microenvironment and tumor immunology. He obtained his Ph.D. in 2014 from Tohoku University Graduate School of Medicine. His graduate work focused the functional interrelation between non-receptor tyrosine kinase c-ABL and tumor suppressor protein p53 during DNA damage response.

He did his postdoctoral training in Pathology at UT Southwestern Medical Center. During his postdoctoral training he investigated functional interaction between gut microbiome and pattern recognition receptors such as TLRs, NLRs, and their involvement in gastrointestinal disorders such as inflammatory bowel disease, colorectal cancer and hepatocellular carcinogenesis.

Dr. Udden joined the department of Radiation Oncology on May 2018. His current research focuses on elucidating molecular mechanisms of endocrine therapy resistance in breast cancer, establishing patient-derived xenograft models to test novel therapeutic agents against treatment-refractory breast cancer, and investigating the role of gut microbiome in regulating the efficacy of anti-cancer therapy.

Undergraduate

University of Dhaka (2005), Molecular Biology

Graduate School

(2014), Medical Sciences

• BET inhibitors / epigenetic approach for endocrine therapy resistant breast cancer
• Breast cancer, colorectal cancer, and hepatocellular carcinoma
• Gut microbiome in regulating the efficacy of anti-cancer therapy
• Novel therapeutic agents against treatment-refractory breast cancer
• Radiation-mediated immunity and tumor regression
• Tumor immunology

Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy

Udden SM, Baek GH, Pandey K, Vidal C, Liu Y, Rahimi AS, Kim DN, Nwachukwu CR, Mani RS, Alluri PG npj Precision Oncology 2023 Dec 7

Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition

Udden SN, Wang Q, Kumar S, Malladi VS, Wu SY, Wei S, Posner BA, Geboers S, Williams NS, Liu Y, Sharma JK, Mani RS, Malladi S, Parra K, Hofstad M, Raj GV, Larios JM, Jagsi R, Wicha MS, Park BH, Gupta GP, Chinnaiyan AM, Chiang CM, Alluri PG JCI Insight 2022 Sep 7

LncRNA HOTAIR regulates glucose transporter Glut1 expression and glucose uptake in macrophages during inflammation

Obaid M, Udden SM, Alluri P, Mandal SS Scientific reports 2021 Dec 11

HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol

Hussain I, Deb P, Chini A, Obaid M, Bhan A, Ansari KI, Mishra BP, Bobzean SA, Udden SM, Alluri PG, Das HK, Brothers RM, Perrotti LI, Mandal SS Frontiers in Genetics 2020 Dec 11

NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte

Udden SN, Kwak YT, Godfrey V, Khan MA, Khan S, Loof N, Peng L, Zhu H, Zaki H eLife 2019 Apr 8

Inflammatory Proteomic Network Analysis of Statin-treated and Lipopolysaccharide-activated Macrophages

Kamal AH, Chakrabarty JK, Udden SM, Zaki MH, Chowdhury SM Scientific reports 2018 Dec 8

LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages

Obaid M, Udden SM, Deb P, Shihabeddin N, Zaki H, Mandal SS Scientific reports 2018 Dec 8

NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways

Udden SM, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH Cell Reports 2017 Jun 19 2756-2770

The ex vivo colon organ culture and its use in antimicrobial host defense studies

Udden SM, Waliullah S, Harris M, Zaki H Journal of Visualized Experiments 2017 Feb 2017

C-ABL tyrosine kinase modulates p53-dependent p21 induction and ensuing cell fate decision in response to DNA damage

Udden SM, Morita-Fujimura Y, Satake M, Ikawa S Cellular Signalling 2014 Feb 26 444-452

• AAI Trainee Abstract Award
  (2018)
• Tohoku University Travel Award
  (2012)
• Monbukagakusho Scholarship, The Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
  (2009-2014)
• Undergraduate/Graduate Scholarship, University of Dhaka, Bangladesh
  (1998-2005)

• American Association for Advancement of Sciences (2011)
• American Association for Cancer Research (2011)
• American Association of Immunologist (2018)
• Bangladesh Society for Biochemistry and Molecular Biology (2005)