Biography

Dr. Udden is an immuno-oncology scientist with expertise in DNA damage response, mucosal immunity, host pathogen interaction, tumor microenvironment and tumor immunology. He obtained his Ph.D. in 2014 from Tohoku University Graduate School of Medicine. His graduate work focused the functional interrelation between non-receptor tyrosine kinase c-ABL and tumor suppressor protein p53 during DNA damage response.

He did his postdoctoral training in Pathology at UT Southwestern Medical Center. During his postdoctoral training he investigated functional interaction between gut microbiome and pattern recognition receptors such as TLRs, NLRs, and their involvement in gastrointestinal disorders such as inflammatory bowel disease, colorectal cancer and hepatocellular carcinogenesis.

Dr. Udden was recruited to the department of Radiation Oncology to work in Alluri lab. His current research focuses on elucidating molecular mechanisms of endocrine therapy resistance in breast cancer, establishing patient-derived xenograft models to test novel therapeutic agents against treatment-refractory breast cancer, and investigating the role of gut microbiome in regulating the efficacy of anti-cancer therapy.

Education

Undergraduate
University of Dhaka (2005), Molecular Biology
Graduate School
(2014), Medical Sciences

Research Interest

  • BET inhibitors / epigenetic approach for endocrine therapy resistant breast cancer
  • Breast cancer, colorectal cancer, and hepatocellular carcinoma
  • Gut microbiome in regulating the efficacy of anti-cancer therapy
  • Novel therapeutic agents against treatment-refractory breast cancer
  • Radiation-mediated immunity and tumor regression
  • Tumor immunology

Publications

Featured Publications LegendFeatured Publications

LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages.
Obaid M, Udden SMN, Deb P, Shihabeddin N, Zaki MH, Mandal SS Sci Rep 2018 Oct 8 1 15670
Inflammatory Proteomic Network Analysis of Statin-treated and Lipopolysaccharide-activated Macrophages.
Kamal AHM, Chakrabarty JK, Udden SMN, Zaki MH, Chowdhury SM Sci Rep 2018 Jan 8 1 164
NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.
Udden SMN, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH Cell Rep 2017 Jun 19 13 2756-2770
The Ex Vivo Colon Organ Culture and Its Use in Antimicrobial Host Defense Studies.
Udden SM, Waliullah S, Harris M, Zaki H J Vis Exp 2017 Feb 120
c-ABL tyrosine kinase modulates p53-dependent p21 induction and ensuing cell fate decision in response to DNA damage.
Udden SM, Morita-Fujimura Y, Satake M, Ikawa S Cell. Signal. 2014 Feb 26 2 444-52
Quorum-regulated biofilms enhance the development of conditionally viable, environmental Vibrio cholerae.
Kamruzzaman M, Udden SM, Cameron DE, Calderwood SB, Nair GB, Mekalanos JJ, Faruque SM Proc. Natl. Acad. Sci. U.S.A. 2010 Jan 107 4 1588-93
Effect of phage on the infectivity of Vibrio cholerae and emergence of genetic variants.
Zahid MS, Udden SM, Faruque AS, Calderwood SB, Mekalanos JJ, Faruque SM Infect. Immun. 2008 Nov 76 11 5266-73
Acquisition of classical CTX prophage from Vibrio cholerae O141 by El Tor strains aided by lytic phages and chitin-induced competence.
Udden SM, Zahid MS, Biswas K, Ahmad QS, Cravioto A, Nair GB, Mekalanos JJ, Faruque SM Proc. Natl. Acad. Sci. U.S.A. 2008 Aug 105 33 11951-6
Transmissibility of cholera: in vivo-formed biofilms and their relationship to infectivity and persistence in the environment.
Faruque SM, Biswas K, Udden SM, Ahmad QS, Sack DA, Nair GB, Mekalanos JJ Proc. Natl. Acad. Sci. U.S.A. 2006 Apr 103 16 6350-5

Honors & Awards

  • AAI Trainee Abstract Award
    (2018)
  • Tohoku University Travel Award
    (2012)
  • Monbukagakusho Scholarship, The Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
    (2009-2014)
  • Undergraduate/Graduate Scholarship, University of Dhaka, Bangladesh
    (1998-2005)

Professional Associations/Affiliations

  • American Association of Immunologist (2018)
  • American Association for Advancement of Sciences (2011)
  • American Association for Cancer Research (2011)
  • Bangladesh Society for Biochemistry and Molecular Biology (2005)