Yan Peng, M.D., Ph.D.

Dr. Yan Peng completed her pediatric residency/chief resident at Beijing Medical University (Peking University Health Science Center) and practiced there as a pediatric nephrologist for two years. After a combined six years of basic science research on kidney disease at Mayo Clinic in Rochester and UT Southwestern Medical Center (UTSW), she went to the University of Pittsburgh Medical Center (UPMC) for pathology residency. After the residency training, she completed two ACGME accredited fellowships in Breast and Gynecologic Pathology and Cytopathology at UPMC and Harvard Medical School, respectively.

Dr. Peng is a surgical pathologist and cytopathologist with extensive expertise in breast and gynecologic pathology and certified by the American Board of Pathology in Anatomic Pathology, Clinical Pathology and Cytopathology. She is the pathology representative at the Cancer Committee of the National Cancer Institute (NCI)-designated comprehensive Simmons Cancer Center. She served as Medical Director of Diagnostic Immunohistochemistry Laboratory and Tumor Biomarker Image Analysis Laboratory for about 10 years.

Dr. Peng has participated in multiple NCI breast and gynecologic cancer clinical trials and has served as a clinical investigator for the NCI Cancer Therapy Evaluation Program. She is a co-investigator in multiple NIH RO1 funded research projects on identifying novel therapeutic targets for triple negative breast cancer.

Dr. Peng has published more than 100 peer-reviewed articles. She is an editor of a textbook entitled Practical Breast Pathology (Springer), guest editor of a special issue entitled Updates on Breast Pathology for Seminars in Diagnostic Pathology (Elsevier), and an author of multiple book chapters of breast pathology textbooks. She has served as an editorial board member for multiple scientific journals including Cancers and Human Pathology (Elsevier), and been an invited reviewer for Biomaterials, Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, eBioMedicine, Oncogene, etc. She is the section editor of Gynecologic Pathology of Human Pathology Reports (Elsevier).

Dr. Peng has been a member of the University Faculty Promotion and Tenure Committee. She is the chair of Pathology Faculty Mentoring Committee and the facility site director of breast pathology fellowship. She is a past president of North Texas Society of Pathologists. 

Medical School

Beijing Medical University (1986)

Residency

Beijing University Hospital (1989), Pediatrics

Graduate School

Beijing Medical University, China (1991)

Other Post Graduate Training

Beijing Medical University, China (1991)

Fellowship

Mayo Clinic College of Medicine (1995), Physiology

Fellowship

UT Southwestern Medical Center (1999), Molecular Nephrology Research

Residency

University of Pittsburgh Medical Center (2003), Anatomic & Clinical Pathology

Fellowship

University of Pittsburgh Medical Center Magee Womens Hospital (2004), Breast & Gynecologic Pathology

Fellowship

Harvard Medical School/Beth Israel Deaconess Medical Center (2005), Cytopathology

• Breast Cancer and Gynecologic Cancer Pathology
• Diagnostic Immunohistochemistry: Theranostic and Genomic Applications
• Prognostic and predictive tumor biomarkers

Featured Publications

Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer.

Palakurthi B, Fross SR, Guldner IH, Aleksandrovic E, Liu X, Martino AK, Wang Q, Neff RA, Golomb SM, Lewis C, Peng Y, Howe EN, Zhang S, Nat Commun 2023 Apr 14 1 2109

TRPS1 and GATA3 Expression in Invasive Breast Carcinoma With Apocrine Differentiation.

Wang J, Peng Y, Sun H, Aung PP, Resetkova E, Yam C, Sahin AA, Huo L, Ding Q, Arch Pathol Lab Med 2023 Apr

Current Biological, Pathological and Clinical Landscape of HER2-Low Breast Cancer.

Zhang H, Peng Y, Cancers (Basel) 2022 Dec 15 1

HER2-low breast cancers: Current insights and future directions.

Zhang H, Karakas C, Tyburski H, Turner BM, Peng Y, Wang X, Katerji H, Schiffhauer L, Hicks DG, Semin Diagn Pathol 2022 Jul

Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress.

Liu X, Viswanadhapalli S, Kumar S, Lee TK, Moore A, Ma S, Chen L, Hsieh M, Li M, Sareddy GR, Parra K, Blatt EB, Reese TC, Zhao Y, Chang A, Yan H, Xu Z, Pratap UP, Liu Z, Roggero CM, Tan Z, Weintraub ST, Peng Y, Tekmal RR, Arteaga CL, Lippincott-Schwartz J, Vadlamudi RK, Ahn JM, Raj GV, Nat Cancer 2022 Jun

Update on prognostic and predictive biomarkers of breast cancer.

Hou Y, Peng Y, Li Z, Semin Diagn Pathol 2022 Jun

Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness.

Parida PK, Marquez-Palencia M, Nair V, Kaushik AK, Kim K, Sudderth J, Quesada-Diaz E, Cajigas A, Vemireddy V, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Huffman K, Sahoo S, Alluri P, Lewis C, Peng Y, Bachoo RM, Arteaga CL, Hanker AB, DeBerardinis RJ, Malladi S, Cell Metab 2022 Jan 34 1 90-105.e7

The Role of Breast Cancer Stem Cells in Chemoresistance and Metastasis in Triple-Negative Breast Cancer.

He L, Wick N, Germans SK, Peng Y, Cancers (Basel) 2021 Dec 13 24

Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers.

Challa S, Khulpateea BR, Nandu T, Camacho CV, Ryu KW, Chen H, Peng Y, Lea JS, Kraus WL, Cell 2021 Jul

HER2 Positive and HER2 Negative Classical Type Invasive Lobular Carcinomas: Comparison of Clinicopathologic Features.

He L, Araj E, Peng Y, Curr Oncol 2021 Apr 28 3 1608-1617

 Featured Books

Invasive Breast Carcinomas. In Peng Y, Kong C, and Chen Y. Practical Breast Pathology. Atkins K and Kong C (eds.), a volume in the Pattern Recognition Series. Kevin O. Leslie and Mark R.Wick (eds.).

Peng Y, Kong C, and Chen Y. (2013; 147-212). Philadelphia, PA, Elsevier

Practical Breast Pathology

Yan Peng, Ping Tang (Ed.) (2019). New York, Springer

Immunohistochemistry in Breast Cancer. In Practical Breast Pathology

Ping Tang, Marilyn M. Bui, Yan Peng (2019). New York, Springer

Breast Cancer with Hereditary Cancer Predisposition Syndromes. In Practical Breast Pathology

Roshni Rao, Caitlin B. Mauer, Margaret Chen-Seetoo, Yan Peng (2019). New York, Springer

Metastatic Tumors in the Breast. In Breast Pathology (Third Edition)

Zaibo Li, David Dabbs, Yan Peng (2023). Philadelphia, PA USA, Elsevier

• Top Doctor (Pathologist)
  Texas Magazine (2022)
• Session Chair, The Breast Pathology Platform Sessions for the United States and Canadian Academy of Pathology (USCAP) 110th annual meeting
  (2021)
• Outstanding peer reviewer for Human Pathology (one of leading pathology scientific journals in the US)
  (2018)
• Member, Abstract Review Board of United States and Canadian Academy of Pathology (Breast Pathology Category)
  (2017-2020)
• President, International Association of Chinese Pathologists
  (2017-2018)
• President, UT Southwestern Faculty Senate
  (2017-2018)
• Finalist for Best Scientific Abstract Award of American Society for Clinical Pathology (senior mentor)
  (2015)
• Distinguished Young Investigator Award in Medicine
  Beijing, China (1993)
• Distinguished Scientist Award of Canada China Child Health Foundation
  (1992)
• Best National Medical Article Award
  China (1991)