Salwa Sebti, Ph.D.

Salwa Sebti, Ph.D., is an Instructor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Infectious Diseases and Geographic Medicine.

Originally from Rennes, France, Dr. Sebti holds a bachelor's degree in biology and physiology and a master's degree in health biology and cancer biology from the University of Toulouse. She completed her doctorate in cell and molecular biology at the University of Montpellier. She then came to UT Southwestern to receive postdoctoral training in autophagy and cell biology under the direction of Beth Levine, M.D.

Dr. Sebti joined the UT Southwestern faculty in 2020.

Dr. Sebti's research interests include understanding the role of autophagy in cancer and aging. 

• Aging
• Autophagy
• Cancer

Featured Publications

Comprehensive autophagy evaluation in cardiac disease models.

Kaludercic N, Maiuri MC, Kaushik S, Fernández ÁF, de Bruijn J, Castoldi F, Chen Y, Ito J, Mukai R, Murakawa T, Nah J, Pietrocola F, Saito T, Sebti S, Semenzato M, Tsansizi L, Sciarretta S, Madrigal-Matute J, Cardiovasc. Res. 2020 Mar 116 3 483-504

The tripartite interaction of phosphate, autophagy, and aKlotho in health maintenance.

Shi M, Maique J, Shaffer J, Davidson T, Sebti S, Fernández ÁF, Zou Z, Yan S, Levine B, Moe OW, Hu MC, FASEB J. 2020 Feb 34 2 3129-3150

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.

Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B, Nature 2018 06 558 7708 136-140

Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.

Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E, Oncotarget 2015 Sep 6 29 28084-103

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated with Estrogen Receptor-Negative Subtypes and Poor Prognosis.

Tang H, Sebti S, Titone R, Zhou Y, Isidoro C, Ross TS, Hibshoosh H, Xiao G, Packer M, Xie Y, Levine B, EBioMedicine 2015 Mar 2 3 255-263

BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization.

Sebti S, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S, Autophagy 2014 Jul 10 7 1341-2

BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.

Sebti S, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S, Proc. Natl. Acad. Sci. U.S.A. 2014 Mar 111 11 4115-20

• ATIP-Avenir Award
  Institute of Biological Sciences (2023)