Biography

Dr. Sebti is originally from France and received her PhD at the University of Montpellier, France. She specializes in cancer biology and the regulation of autophagy. She joined the Center for Autophagy Research at UTSW to pursue her research interest in understanding the role of autophagy in cancer and aging. Dr. Sebti has shown that increased autophagy is associated with increased lifespan and healthspan in mice. Her work also correlates low mRNA expression of the essential autophagy gene Beclin 1, with poor prognosis in breast cancer.

Research Interest

  • Aging
  • Autophagy
  • Cancer

Publications

Featured Publications LegendFeatured Publications

Comprehensive autophagy evaluation in cardiac disease models.
Kaludercic N, Maiuri MC, Kaushik S, Fernández ÁF, de Bruijn J, Castoldi F, Chen Y, Ito J, Mukai R, Murakawa T, Nah J, Pietrocola F, Saito T, Sebti S, Semenzato M, Tsansizi L, Sciarretta S, Madrigal-Matute J, Cardiovasc. Res. 2020 Mar 116 3 483-504
The tripartite interaction of phosphate, autophagy, and aKlotho in health maintenance.
Shi M, Maique J, Shaffer J, Davidson T, Sebti S, Fernández ÁF, Zou Z, Yan S, Levine B, Moe OW, Hu MC, FASEB J. 2020 Feb 34 2 3129-3150
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B, Nature 2018 06 558 7708 136-140
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E, Oncotarget 2015 Sep 6 29 28084-103
Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated with Estrogen Receptor-Negative Subtypes and Poor Prognosis.
Tang H, Sebti S, Titone R, Zhou Y, Isidoro C, Ross TS, Hibshoosh H, Xiao G, Packer M, Xie Y, Levine B, EBioMedicine 2015 Mar 2 3 255-263
BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization.
Sebti S, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S, Autophagy 2014 Jul 10 7 1341-2
BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.
Sebti S, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S, Proc. Natl. Acad. Sci. U.S.A. 2014 Mar 111 11 4115-20