Sam Wang, M.D., is an Assistant Professor in the Division of Surgical Oncology in the Department of Surgery at UT Southwestern Medical Center. His clinical focus includes cancers of the liver, pancreas, stomach, and bile duct.

Dr. Wang graduated from Stanford University, where he received a B.S. with honors in biological science and an A.B. with high honors in history. He attended medical school at Duke University School of Medicine and completed an internship and residency in general surgery at the University of California, San Francisco. He then received advanced training in complex general surgical oncology through a fellowship at Memorial Sloan Kettering Cancer Center. He joined the UT Southwestern faculty in 2014.

In the lab, Dr. Wang is interested in how the normal regenerative process mutates and leads to cancer. In addition, he is studying the molecular mechanisms behind outcome disparities that Hispanic gastric cancer patients face. The goals for his research are to identify new diagnostic and therapeutic strategies to improve outcomes for these patients.

Dr. Wang is a member of the Society of Surgical Oncology, the Association for Academic Surgery, the American Association for Cancer Research, and the American College of Surgeons. He is fluent in Mandarin.


Medical School
Duke University School of Medicine (2005)
UCSF School of Medicine (2012), Surgery
Memorial Sloan-Kettering Cancer Center (2014), Surgical Oncology

Research Interest

  • Epigenetic changes in cancer
  • Gastric, pancreas, and liver cancer
  • Molecular mechanisms behind disparities in cancer outcomes
  • Role of tissue injury and regeneration on cancer formation


Featured Publications LegendFeatured Publications

Precise let-7 expression levels balance organ regeneration against tumor suppression.
Wu L, Nguyen LH, Zhou K, de Soysa TY, Li L, Miller JB, Tian J, Locker J, Zhang S, Shinoda G, Seligson MT, Zeitels LR, Acharya A, Wang SC, Mendell JT, He X, Nishino J, Morrison SJ, Siegwart DJ, Daley GQ, Shyh-Chang N, Zhu H Elife 2015 Oct 4
Pretreatment Neutrophil to Lymphocyte Ratio Independently Predicts Disease-specific Survival in Resectable Gastroesophageal Junction and Gastric Adenocarcinoma.
Wang SC, Chou JF, Strong VE, Brennan MF, Capanu M, Coit DG Ann. Surg. 2015 Apr
Management of well-differentiated gastrointestinal neuroendocrine tumors metastatic to the liver.
Wang SC, Fidelman N, Nakakura EK Semin. Oncol. 2013 Feb 40 1 69-74
Lymph node sampling rates and predictors of nodal metastasis in pancreatic neuroendocrine tumor resections: the UCSF experience with 149 patients.
Parekh JR, Wang SC, Bergsland EK, Venook AP, Warren RS, Kim GE, Nakakura EK Pancreas 2012 Aug 41 6 840-4
Complete and safe resection of challenging retroperitoneal tumors: anticipation of multi-organ and major vascular resection and use of adjunct procedures.
Tseng WW, Wang SC, Eichler CM, Warren RS, Nakakura EK World J Surg Oncol 2011 9 143
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.
Morris JP, Wang SC, Hebrok M Nat. Rev. Cancer 2010 Oct 10 10 683-95
Identification of unknown primary tumors in patients with neuroendocrine liver metastases.
Wang SC, Parekh JR, Zuraek MB, Venook AP, Bergsland EK, Warren RS, Nakakura EK Arch Surg 2010 Mar 145 3 276-80
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.
Morris JP, Cano DA, Sekine S, Wang SC, Hebrok M J. Clin. Invest. 2010 Feb 120 2 508-20
Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure.
Sano M, Wang SC, Shirai M, Scaglia F, Xie M, Sakai S, Tanaka T, Kulkarni PA, Barger PM, Youker KA, Taffet GE, Hamamori Y, Michael LH, Craigen WJ, Schneider MD, EMBO J. 2004 Sep 23 17 3559-69
Telomere attrition and Chk2 activation in human heart failure.
Oh H, Wang SC, Prahash A, Sano M, Moravec CS, Taffet GE, Michael LH, Youker KA, Entman ML, Schneider MD, Proc. Natl. Acad. Sci. U.S.A. 2003 Apr 100 9 5378-83

Honors & Awards

  • Jacobson Promising Investigator Award
    American College of Surgeons (2019)
  • Faculty Research Fellowship
    American College of Surgeons (2017-2019)
  • Health Care Disparities Research Award
    Society for Surgery of the Alimentary Tract (2017-2019)
  • Outstanding Mentor, Center for Translational Medicine
    University of Texas Southwestern Medical Center (2017)
  • Disease-Oriented Clinical Scholar
    University of Texas Southwestern Medical Center (2015-2018)
  • Conquer Cancer Foundation Merit Award
    American Society of Clinical Oncology (2014)
  • Outstanding Resident Achievement Award
    Department of Surgery, University of California, San Francisco (2012)

Professional Associations/Affiliations

  • Society for Surgery of the Alimentary Tract (2016)
  • Dallas Country Medical Society (2014)
  • Texas Medical Association (2014)
  • Association for Academic Surgery (2013)
  • Society of Surgical Oncology (2013)
  • UCSF Naffziger Surgical Society (2012)
  • American Association for Cancer Research (2008)
  • American Association for Cancer Research (2008)
  • American College of Surgeons (2005)