Dr. Yingfei Wang obtained her Ph.D. degree in Neuroscience at the University of Magdeburg in Germany and completed her postdoctoral training at the Johns Hopkins School of Medicine. Currently Dr. Wang is an Assistant Professor in the Department of Pathology and Neurology at UT Southwestern.
Dr. Wang studies the molecular and cellular mechanisms of cell death using in vitro and in vivo models of neurodegenerative diseases and cancers. The current research topics are 1) mitochondrial dysfunction and neurodegeneration; 2) DNA damage- and oxidative stress-induced cell death, especially poly(ADP-ribose) polymerase-1 (PARP-1) dependent cell death (parthanatos) in neurons as well as cancer cells. PARP-1 is a nuclear enzyme and plays an important role in cell death through a caspase-independent manner after ischemia-reperfusion injury, glutamate excitotoxicity and various inflammatory responses, as well as other neurologic and non-neurologic diseases. We recently identified a novel PARP-1 activity associated nuclease (PAAN) as the executioner of parthanatos (Wang Y., et al. Science, 2016). Our studies have made significant contributions in understanding parthanatos in ischemic brain injury. Currently, our lab is using a combination of tools, including epigenetics, bioinformatics, proteomics and mouse genetics, to understand the cell signaling and regulation of PARP-1 dependent DNA damage and cell death in human cancers as well as neurologic diseases. Our overall goals are to identify novel therapeutic targets and translate the knowledge to prevent neuron loss but enhance cancer cell death.
- Cell Death and Survival
- Mitochondrial dysfunction and neurodegeneration
- PARP-1 and DNA Damage
- Stroke and brain injury
- The role of calcium in protease-activated receptor-induced secretion of chemokine GRO/CINC-1 in rat brain astrocytes.
- Wang Y, Luo W, Reiser G J. Neurochem. 2007 Oct 103 2 814-9
- Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain.
- Wang Y, Luo W, Reiser G Biochem. J. 2007 Jan 401 1 65-78
- Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes.
- Wang Y, Luo W, Wartmann T, Halangk W, Sahin-Tóth M, Reiser G J. Neurochem. 2006 Nov 99 3 759-69
- Protease-activated receptor-1 protects rat astrocytes from apoptotic cell death via JNK-mediated release of the chemokine GRO/CINC-1.
- Wang Y, Luo W, Stricker R, Reiser G J. Neurochem. 2006 Aug 98 4 1046-60
- Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1.
- Luo W, Wang Y, Hanck T, Stricker R, Reiser G J. Biol. Chem. 2006 Mar 281 12 7927-36
- Two types of protease-activated receptors (PAR-1 and PAR-2) mediate calcium signaling in rat retinal ganglion cells RGC-5.
- Luo W, Wang Y, Reiser G Brain Res. 2005 Jun 1047 2 159-67
- Molecular recognition in purinergic receptors. 2. Diastereoselectivity of the h-P2Y1-receptor.
- Major DT, Nahum V, Wang Y, Reiser G, Fischer B J. Med. Chem. 2004 Aug 47 18 4405-16
- Expression of protease-activated receptors (PARs) in OLN-93 oligodendroglial cells and mechanism of PAR-1-induced calcium signaling.
- Wang Y, Richter-Landsberg C, Reiser G Neuroscience 2004 126 1 69-82
The role of thrombin and thrombin receptors in the brain.. In Thrombin: Physiology and Disease
Luo W, Wang Y, Reiser G. (2008). Springer Verlag
Honors & Awards
- CPRIT HIHR Award
- R35 Maximizing Investigators Research Award
- Welch Research Award
- Darrell K Royal (DKR) Research Award
- Texas Institute for Brain injury and Repair (TIBIR) Pilot Grant
- UT Rising Star Award
- American Heart Association (AHA) National Scientist Development Grant Award
- NIH Pathway to Independence Award (Parent K99/R00)
- American Heart Association (AHA) Postdoctoral Fellowship Award
- Chinese Government Award for Outstanding Student Abroad
- Summa cum laude for Ph.D dissertation
- German Research Foundation DFG Scholarship
- Member of American Association for Cancer Research (AACR) (2015)
- Member of American Heart Association (AHA) (2012)
- Associate Faculty Member of Faculty of 1000 Biology (2011-2012)
- Member of Society for Neuroscience (2007)