Biography

Dr. Yingfei Wang obtained her Ph.D. degree in Neuroscience at the University of Magdeburg in Germany and completed her postdoctoral training at the Johns Hopkins School of Medicine. Currently Dr. Wang is an Assistant Professor in the Department of Pathology and Neurology at UT Southwestern. 

Dr. Wang studies the molecular and cellular mechanisms of DNA damage and oxidative stress induced poly(ADP-ribose) polymerase-1 (PARP-1) dependent cell death (parthanatos) in neurons as well as cancer cells. PARP-1 is a nuclear enzyme and plays an important role in cell death through a caspase-independent manner after ischemia-reperfusion injury, glutamate excitotoxicity and various inflammatory responses, as well as other neurologic and non-neurologic diseases. Dr. Wang uses a combination of tools, including epigenetics, bioinformatics, proteomics and mouse genetics, to understand the cell signaling and regulation of PARP-1 dependent DNA damage and cell death. Her overall goals are to identify novel therapeutic targets and translate the knowledge to prevent neuron loss but enhance cancer cell death.

Research Interest

  • Cell Death and Survival
  • DNA Damage
  • Epigenetics
  • Nuclease
  • PARP-1
  • Stroke and brain injury

Publications

Featured Publications LegendFeatured Publications

Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-a protein stability and activity
Luo W, Wang Y Cell. Mol. Life Sci. 2017
HIF repressors under chronic hypoxia.
Luo W, Wang Y Aging (Albany NY) 2016 Mar
PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia.
Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza GL Oncotarget 2016 Feb

Books

Featured Books Legend Featured Books

Honors & Awards

  • CPRIT HIHR Award
    (2017-2019)
  • R35 Maximizing InvestigatorÂ’s Research Award
    (2017-2022)
  • Welch Research Award
    (2017-2020)
  • Darrell K Royal (DKR) Research Award
    (2015-2018)
  • Texas Institute for Brain injury and Repair (TIBIR) Pilot Grant
    (2015-2017)
  • UT Rising Star Award
    (2014-2017)
  • American Heart Association (AHA) National Scientist Development Grant Award
    (2012)
  • NIH Pathway to Independence Award (Parent K99/R00)
    (2012-2017)
  • American Heart Association (AHA) Postdoctoral Fellowship Award
    (2008-2010)
  • Chinese Government Award for Outstanding Student Abroad
    (2007)
  • Summa cum laude for Ph.D dissertation
    (2007)
  • German Research Foundation DFG Scholarship
    (2002-2005)

Professional Associations/Affiliations

  • Member of American Association for Cancer Research (AACR) (2015)
  • Member of American Heart Association (AHA) (2012)
  • Associate Faculty Member of Faculty of 1000 Biology (2011-2012)
  • Member of Society for Neuroscience (2007)