Dr. Yingfei Wang obtained her Ph.D. degree in Neuroscience at the University of Magdeburg in Germany and completed her postdoctoral training at the Johns Hopkins School of Medicine. Currently Dr. Wang is an Assistant Professor in the Department of Pathology and Neurology at UT Southwestern.
Dr. Wang studies the molecular, cellular and metabolic mechanisms of cell death using in vitro and in vivo models of neurodegenerative diseases and cancers. The current research topics are 1) mitochondrial dysfunction and neurodegeneration; 2) ischemic brain injury-, hypoxia- and DNA damage-induced cell death, especially poly(ADP-ribose) polymerase-1 (PARP-1) dependent cell death (parthanatos) in neurons as well as cancer cells. PARP-1 is a nuclear enzyme and plays an important role in cell death through a caspase-independent manner after ischemia-reperfusion injury, glutamate excitotoxicity and various inflammatory responses, as well as other neurologic and non-neurologic diseases. We recently identified a novel PARP-1 activity associated nuclease (PAAN) as the executioner of parthanatos (Wang Y., et al. Science, 2016). Our studies have made significant contributions in understanding parthanatos in ischemic brain injury. Currently, our lab is using a combination of tools, including epigenetics, bioinformatics, proteomics and mouse genetics, to understand the cell signaling and regulation of PARP-1 dependent DNA damage and cell death in human cancers as well as neurologic diseases. Our overall goals are to identify novel therapeutic targets and translate the knowledge to prevent neuron loss but enhance cancer cell death.
- Cell Death
- Hypoxia and ischemic brain injury
- Mitochondrial dysfunction and neurodegeneration
- PARP-1 and DNA Damage
- CHD4 promotes breast cancer progression as a coactivator of hypoxia-inducible factors.
- Wang Y, Chen Y, Bao L, Zhang B, Wang JE, Kumar A, Xing C, Wang Y, Luo W, Cancer Res. 2020 Jul
- Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma.
- Zhang B, Chen Y, Shi X, Zhou M, Bao L, Hatanpaa KJ, Patel T, DeBerardinis RJ, Wang Y, Luo W, Cell. Mol. Life Sci. 2020 Feb
- HIF-2-induced long non-coding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis.
- Niu Y, Bao L, Chen Y, Wang C, Luo M, Zhang B, Zhou M, Wang JE, Fang YV, Kumar A, Xing C, Wang Y, Luo W, Cancer Res. 2020 Jan
- PARP-1 and its associated nucleases in DNA damage response.
- Wang Y, Luo W, Wang Y, DNA Repair (Amst.) 2019 Jul 102651
- Hypoxia Mediates Tumor Malignancy and Therapy Resistance.
- Luo W, Wang Y, Adv. Exp. Med. Biol. 2019 1136 1-18
- ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis
- Chen Y, Zhang B, Bao L, Jin L, Yang M, Peng Y, Kumar A, Wang JE, Wang C, Zou X, Xing C, Wang Y*, Luo W* J Clin Invest. 2018 PMID: 29629903 (* Corresponding authors)
- Methylation of hypoxia-inducible factor (HIF)-1a by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
- Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y*, Luo W*. Nucleic Acids Res. 2018 PMID: 29860315 (*Corresponding authors)
- A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
- Wang Y*, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim BW, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam T, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL*, Dawson TM* Science 2016 PMID: 27846469 (* Corresponding authors)
- Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos).
- Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL, Dawson TM Sci Signal 2011 4 167 ra20
- Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos.
- Wang Y, Dawson VL, Dawson TM Exp. Neurol. 2009 Aug 218 2 193-202
The role of thrombin and thrombin receptors in the brain.. In Thrombin: Physiology and Disease
Luo W, Wang Y, Reiser G. (2008). Springer Verlag
Honors & Awards
- NIA R01 grant
- CPRIT HIHR Award
- R35 Maximizing Investigators Research Award
- Welch Research Award
- Darrell K Royal (DKR) Research Award
- Texas Institute for Brain injury and Repair (TIBIR) Pilot Grant
- UT Rising Star Award
- American Heart Association (AHA) National Scientist Development Grant Award
- NIH Pathway to Independence Award (Parent K99/R00)
- American Heart Association (AHA) Postdoctoral Fellowship Award
- Chinese Government Award for Outstanding Student Abroad
- Summa cum laude for Ph.D dissertation
- German Research Foundation DFG Scholarship
- Member of American Association for Cancer Research (AACR) (2015)
- Member of American Heart Association (AHA) (2012)
- Associate Faculty Member of Faculty of 1000 Biology (2011-2012)
- Member of Society for Neuroscience (2007)