Research Interest

  • Age-related macular degeneration
  • Chemical biology
  • Drug discovery
  • Extracellular matrix proteins
  • Inherited retinal dystrophies
  • Ocular protein misfolding diseases
  • Stress-responsive signaling


Featured Publications LegendFeatured Publications

Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1.
Madian AG, Hindupur J, Hulleman JD, Diaz-Maldonado N, Mishra VR, Guigard E, Kay CM, Rochet JC, Regnier FE Mol. Cell Proteomics 2012 Feb 11 2 M111.010892
Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration.
Hulleman JD, Kaushal S, Balch WE, Kelly JW Mol. Biol. Cell 2011 Dec 22 24 4765-75
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.
Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW Proc. Natl. Acad. Sci. U.S.A. 2009 Nov 106 44 18563-8
Fabrication of ZnS nanoparticle chains on a protein template.
Padalkar S, Hulleman J, Kim SM, Tumkur T, Rochet JC, Stach E, Stanciu L J Nanopart Res 2009 Nov 11 8 2031-2041
Protein-templated semiconductor nanoparticle chains.
Padalkar S, Hulleman JD, Kim SM, Rochet JC, Stach EA, Stanciu LA Nanotechnology 2008 Jul 19 27 275602
Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease.
Liu F, Nguyen JL, Hulleman JD, Li L, Rochet JC J. Neurochem. 2008 Jun 105 6 2435-53
Biotemplated synthesis of metallic nanoparticle chains on an alpha-synuclein fiber scaffold.
Colby R, Hulleman J, Padalkar S, Rochet JC, Stanciu LA J Nanosci Nanotechnol 2008 Feb 8 2 973-8
Helical alpha-synuclein forms highly conductive ion channels.
Zakharov SD, Hulleman JD, Dutseva EA, Antonenko YN, Rochet JC, Cramer WA Biochemistry 2007 Dec 46 50 14369-79
Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson's disease.
Hulleman JD, Mirzaei H, Guigard E, Taylor KL, Ray SS, Kay CM, Regnier FE, Rochet JC Biochemistry 2007 May 46 19 5776-89
Alpha-synuclein as a template for the synthesis of metallic nanowires
Padalkar S, Hulleman J, Colby R, Cunzeman K, Rochet JC, Stach EA, Stanciu L Nanotechnology 2007 5 18 1-9


Featured Books Legend Featured Books

Alpha-Synuclein self-assembly in Parkinson's disease: Insights from biophysical analyses. In Protein Misfolding in Biology and Disease

Rochet JC and Hulleman JD (2009). Trivandrum, India, Research Signpost

Honors & Awards

  • Bright Focus Foundation
    Macular Degeneration Research Award (2018-2020)
  • National Institutes of Health
    R01EY027785 (2018-2023)
  • National Institutes of Health
    R21EY028261 (2017-2019)
  • Bright Focus Foundation
    Macular Degeneration Research Award (2016-2018)
  • Karl Kirchgessner Foundation
    Vision Research Grant (2016-2019)
  • Research to Prevent Blindness
    Career Development Award (2015-2019)