John Hulleman, Ph.D.
Assistant Professor

• Age-related macular degeneration
• Chemical biology
• Drug discovery
• Extracellular matrix proteins
• Inherited retinal dystrophies
• Ocular protein misfolding diseases
• Stress-responsive signaling

Featured Publications

A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye -- Implications for Ocular Gene Therapy

Datta S, Renwick M, Chau VQ, Zhang F, Nettesheim ER, Lipinski DM, Hulleman JD IOVS 2018 59 12 4909-4920

An inducible form of Nrf2 confers enhanced protection against acute oxidative stresses in RPE cells.

Vu KT, Hulleman JD Exp. Eye Res. 2017 Aug 164 31-36

Conditional, Genetically Encoded, Small Molecule-Regulated Inhibition of NFkB Signaling in RPE Cells.

Vu KT, Zhang F, Hulleman JD Invest Ophthalmol Vis Sci 2017 58 10 4126-4137

Deducing the presence of proteins and proteoforms in quantitative proteomics.

Bamberger C, Martínez-Bartolomé S, Montgomery M, Pankow S, Hulleman JD, Kelly JW, Yates JR Nat Commun 2018 Jun 9 1 2320

High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production.

Wong MY, Doan ND, DiChiara AS, Papa LJ, Cheah JH, Soule CK, Watson N, Hulleman JD, Shoulders MD Biochemistry 2018 Apr

Mapping wild-type and R345W fibulin-3 intracellular interactomes.

Hulleman JD, Genereux JC, Nguyen A Exp. Eye Res. 2016 Oct

A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture.

Zadoo S, Nguyen A, Zode G, Hulleman JD Invest. Ophthalmol. Vis. Sci. 2016 Apr 57 4 1939-1950

Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-Related Macular Degeneration and Potential Therapies.

Hulleman JD Adv. Exp. Med. Biol. 2016 854 153-8

Evidence of Alternative Cystatin C Signal Sequence Cleavage Which Is Influenced by the A25T Polymorphism.

Nguyen A, Hulleman JD PLoS ONE 2016 11 2 e0147684

A novel H395R mutation in MKKS/BBS6 causes retinitis pigmentosa and polydactyly without other findings of Bardet-Biedl or McKusick-Kaufman syndrome.

Hulleman JD, Nguyen A, Ramprasad VL, Murugan S, Gupta R, Mahindrakar A, Angara R, Sankurathri C, Mootha VV Mol. Vis. 2016 22 73-81

 Featured Books

Alpha-Synuclein self-assembly in Parkinson's disease: Insights from biophysical analyses. In Protein Misfolding in Biology and Disease

Rochet JC and Hulleman JD (2009). Trivandrum, India, Research Signpost

• Bright Focus Foundation
  Macular Degeneration Research Award (2018-2020)
• National Institutes of Health
  R01EY027785 (2018-2023)
• National Institutes of Health
  R21EY028261 (2017-2019)
• Bright Focus Foundation
  Macular Degeneration Research Award (2016-2018)
• Karl Kirchgessner Foundation
  Vision Research Grant (2016-2019)
• Research to Prevent Blindness
  Career Development Award (2015-2019)