Research Interest

  • Age-related macular degeneration
  • Chemical biology
  • Drug discovery/high-throughput screening
  • Extracellular matrix proteins
  • Inherited retinal dystrophies
  • Ocular protein misfolding diseases
  • Stress-responsive signaling


Featured Publications LegendFeatured Publications

Utility of the DHFR-based destabilizing domain across mouse models of retinal degeneration and aging.
Peng H, Ramadurgum P, Woodard DR, Daniel S, Nakahara E, Renwick M, Aredo B, Datta S, Chen B, Ufret-Vincenty R, Hulleman JD, iScience 2022 May 25 5 104206
A simple secretion assay for assessing new and existing myocilin variants.
Nakahara E, Hulleman JD, Curr Eye Res 2022 Feb 1-7
A trimethoprim derivative impedes antibiotic resistance evolution.
Manna MS, Tamer YT, Gaszek I, Poulides N, Ahmed A, Wang X, Toprak FCR, Woodard DR, Koh AY, Williams NS, Borek D, Atilgan AR, Hulleman JD, Atilgan C, Tambar U, Toprak E, Nat Commun 2021 May 12 1 2949
A novel homozygous missense mutation p.P388S in TULP1 causes protein instability and retinitis pigmentosa.
Woodard DR, Xing C, Ganne P, Liang H, Mahindrakar A, Sankurathri C, Hulleman JD, Mootha VV, Mol Vis 2021 27 179-190
Two C-terminal sequence variations determine differential neurotoxicity between human and mouse a-synuclein.
Landeck N, Strathearn KE, Ysselstein D, Buck K, Dutta S, Banerjee S, Lv Z, Hulleman JD, Hindupur J, Lin LK, Padalkar S, Stanciu LA, Lyubchenko YL, Kirik D, Rochet JC, Mol Neurodegener 2020 Sep 15 1 49
Delivery of Antisense Oligonucleotides to the Cornea.
Chau VQ, Hu J, Gong X, Hulleman JD, Ufret-Vincenty RL, Rigo F, Prakash TP, Corey DR, Mootha VV, Nucleic Acid Ther 2020 Mar


Featured Books Legend Featured Books

Alpha-Synuclein self-assembly in Parkinson's disease: Insights from biophysical analyses. In Protein Misfolding in Biology and Disease

Rochet JC and Hulleman JD (2009). Trivandrum, India, Research Signpost

Honors & Awards

  • National Institutes of Health
    R21EY033522 (2022-2024)
  • EyeFind Research Grant
    Human Donor Grant (2021-2022)
  • Fichtenbaum Charitable Trust
    Macular Degeneration Research Award (2021-2022)
  • Fichtenbaum Charitable Trust
    Macular Degeneration Research Award (2020-2021)
  • Bright Focus Foundation
    Macular Degeneration Research Award (2018-2020)
  • National Institutes of Health
    R01EY027785 (2018-2023)
  • National Institutes of Health
    R21EY028261 (2017-2019)
  • Bright Focus Foundation
    Macular Degeneration Research Award (2016-2018)
  • Karl Kirchgessner Foundation
    Vision Research Grant (2016-2019)
  • Research to Prevent Blindness
    Career Development Award (2015-2019)

Professional Associations/Affiliations

  • Investigator - Peter O'Donnell Jr. Brain Institute (2021)
  • Adjunct Assistant Professor - University of North Texas Health Science Center (2016)