Research Interest

  • Age-related macular degeneration
  • Chemical biology
  • Drug discovery
  • Extracellular matrix proteins
  • Inherited retinal dystrophies
  • Ocular protein misfolding diseases
  • Stress-responsive signaling


Featured Publications LegendFeatured Publications

A trimethoprim derivative impedes antibiotic resistance evolution.
Manna MS, Tamer YT, Gaszek I, Poulides N, Ahmed A, Wang X, Toprak FCR, Woodard DR, Koh AY, Williams NS, Borek D, Atilgan AR, Hulleman JD, Atilgan C, Tambar U, Toprak E, Nat Commun 2021 May 12 1 2949
A novel homozygous missense mutation p.P388S in TULP1 causes protein instability and retinitis pigmentosa.
Woodard DR, Xing C, Ganne P, Liang H, Mahindrakar A, Sankurathri C, Hulleman JD, Mootha VV, Mol Vis 2021 27 179-190
Two C-terminal sequence variations determine differential neurotoxicity between human and mouse a-synuclein.
Landeck N, Strathearn KE, Ysselstein D, Buck K, Dutta S, Banerjee S, Lv Z, Hulleman JD, Hindupur J, Lin LK, Padalkar S, Stanciu LA, Lyubchenko YL, Kirik D, Rochet JC, Mol Neurodegener 2020 Sep 15 1 49
Delivery of Antisense Oligonucleotides to the Cornea.
Chau VQ, Hu J, Gong X, Hulleman JD, Ufret-Vincenty RL, Rigo F, Prakash TP, Corey DR, Mootha VV, Nucleic Acid Ther 2020 Mar
Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells.
Zhou M, Weber SR, Zhao Y, Chen H, Barber AJ, Grillo SL, Wills CA, Wang HG, Hulleman JD, Sundstrom JM, Front Cell Dev Biol 2020 8 469
Protocol for Designing Small-Molecule-Regulated Destabilizing Domains for In Vitro Use
Ramadurgum P, Hulleman JD STAR Protocols 2020 1; September 18, 2020 100069 1-20


Featured Books Legend Featured Books

Alpha-Synuclein self-assembly in Parkinson's disease: Insights from biophysical analyses. In Protein Misfolding in Biology and Disease

Rochet JC and Hulleman JD (2009). Trivandrum, India, Research Signpost

Honors & Awards

  • EyeFind Research Grant
    Human Donor Grant (2021-2022)
  • Fichtenbaum Charitable Trust
    Macular Degeneration Research Award (2021-2022)
  • Fichtenbaum Charitable Trust
    Macular Degeneration Research Award (2020-2021)
  • Bright Focus Foundation
    Macular Degeneration Research Award (2018-2020)
  • National Institutes of Health
    R01EY027785 (2018-2023)
  • National Institutes of Health
    R21EY028261 (2017-2019)
  • Bright Focus Foundation
    Macular Degeneration Research Award (2016-2018)
  • Karl Kirchgessner Foundation
    Vision Research Grant (2016-2019)
  • Research to Prevent Blindness
    Career Development Award (2015-2019)