Ram Mani, Ph.D. Associate Professor School Medical School Department Pathology | Urology Graduate Programs Cancer Biology, Genetics, Development and Disease Biography Ram Mani, Ph.D. is an Assistant Professor with a joint appointment in the Departments of Pathology and Urology, and is a member of the Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas. He is a recipient of the K99/R00 Pathway to Independence award from the National Institutes of Health and a Young Investigator Award from the Prostate Cancer Foundation. Before starting his research laboratory in 2014, he was a Research Investigator (2011-2014) in the Department of Pathology, University of Michigan, Ann Arbor. His postdoctoral training (2007-2011) is in the area of prostate cancer genomics and epigenetics in Prof. Arul Chinnaiyan’s research group, University of Michigan. His doctoral research from Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore is in the area of human molecular genetics. The overall focus of Dr. Mani’s research group is to study the molecular genetic and epigenetic events associated with cancer development, with the underlying aim of translating this knowledge in to novel diagnostic, prognostic and therapeutic strategies. His research team members employ integrative approaches that include cell-based assays, studies using animal models, analysis of human cancer specimens, next-generation sequencing and bioinformatics to identify (1) the DNA damage and repair pathways that mediate cancer-specific recurrent genomic rearrangements and resistance to targeted therapies, and (2) the functional consequences of epigenetic and transcriptional deregulation in cancer development. These studies will serve as the basis for early cancer detection and therapeutic targeting. The Mani research laboratory is located in the seventh floor of the NB building. Education Graduate School Jawaharlal Nehru Centre ASR (2007), Human Molecular Genetics Research Interest Epigenetic mechanisms underlying cancer progression ETS gene fusions in prostate cancer Genomic rearrangements in cancer Transcriptional regulation in prostate cancer Publications Featured Publications ChIPr: accurate prediction of cohesin-mediated 3D genome organization from 2D chromatin features. Abbas A, Chandratre K, Gao Y, Yuan J, Zhang MQ, Mani RS, Genome Biol 2024 Jan 25 1 15 Prostate cancer transcriptomic regulation by the interplay of germline risk alleles, somatic mutations and 3D-genomic architecture. Yuan J, Houlahan KE, Ramanand SG, Lee S, Baek G, Yang Y, Chen Y, Strand DW, Zhang MQ, Boutros PC, Mani RS, Cancer Discov 2022 Sep Stress and the CITI. Ramanand SG, Mani RS, Mol Cell 2022 Aug 82 15 2730-2731 FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity. Sahoo SS, Ramanand SG, Gao Y, Abbas A, Kumar A, Cuevas IC, Li HD, Aguilar M, Xing C, Mani RS, Castrillon DH, J Clin Invest 2022 Jun 132 12 Targeting radioresistance and replication fork stability in prostate cancer. Li X, Baek G, Carreira S, Yuan W, Ma S, Hofstad M, Lee S, Gao Y, Bertan C, Fenor de la Maza MLD, Alluri PG, Burma S, Chen BP, Raj GV, de Bono J, Pommier Y, Mani RS, JCI Insight 2022 Mar The landscape of RNA polymerase II associated chromatin interactions in prostate cancer. Ramanand SG, Chen Y, Yuan J, Daescu K, Lambros M, Houlahan KE, Carreira S, Yuan W, Baek G, Sharp A, Paschalis A, Kanchwala M, Gao Y, Aslam A, Safdar N, Zhan X, Raj GV, Xing C, Boutros PC, de Bono J, Zhang MQ, Mani RS, J. Clin. Invest. 2020 Apr Genome-wide germline correlates of the epigenetic landscape of prostate cancer. Houlahan KE, Shiah YJ, Gusev A, Yuan J, Ahmed M, Shetty A, Ramanand SG, Yao CQ, Bell C, O'Connor E, Huang V, Fraser M, Heisler LE, Livingstone J, Yamaguchi TN, Rouette A, Foucal A, Espiritu SMG, Sinha A, Sam M, Timms L, Johns J, Wong A, Murison A, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Lupien M, Fradet Y, Têtu B, McPherson JD, Pasaniuc B, Kislinger T, Chua MLK, Pomerantz MM, van der Kwast T, Freedman ML, Mani RS, He HH, Bristow RG, Boutros PC, Nat. Med. 2019 Oct BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer. Li X, Baek G, Ramanand SG, Sharp A, Gao Y, Yuan W, Welti J, Rodrigues DN, Dolling D, Figueiredo I, Sumanasuriya S, Crespo M, Aslam A, Li R, Yin Y, Mukherjee B, Kanchwala M, Hughes AM, Halsey WS, Chiang CM, Xing C, Raj GV, Burma S, de Bono J, Mani RS Cell Rep 2018 Jan 22 3 796-808 Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer. Mani RS, Amin MA, Li X, Kalyana-Sundaram S, Veeneman BA, Wang L, Ghosh A, Aslam A, Ramanand SG, Rabquer BJ, Kimura W, Tran M, Cao X, Roychowdhury S, Dhanasekaran SM, Palanisamy N, Sadek HA, Kapur P, Koch AE, Chinnaiyan AM Cell Rep 2016 Dec 17 10 2620-2631 Induced chromosomal proximity and gene fusions in prostate cancer. Mani RS, Tomlins SA, Callahan K, Ghosh A, Nyati MK, Varambally S, Palanisamy N, Chinnaiyan AM Science 2009 Nov 326 5957 1230 Results 1-10 of 36 1 2 3 4 Next Last Honors & Awards American Cancer Society (ACS-IRG) New Investigator Award in Cancer Research (2014-2015) NIH Pathway to Independence (PI) Award (K99/R00) (2012-2017) AACR-Prostate Cancer Foundation Scholar-in-Training Award (2011) AACR‑Aflac, Incorporated Scholar-in-Training Award (2010) Prostate Cancer Foundation Young Investigator Award (2010-2013)
