Biography

Laura Banaszynski is an Assistant Professor in the Department of Obstetrics and Gynecology and Children's Research Institute. She is a member of the Cecil H. and Ida Green Center for Reproductive Biology Sciences.

Dr. Banaszynski received her BS in Chemistry from The University of Notre Dame in 2000. She completed her PhD in Chemical & Systems Biology with Tom Wandless at Stanford University in 2007. From 2008-2014, she was a Damon Runyon postdoctoral fellow with David Allis at The Rockefeller University. In 2015, Dr. Banaszynski joined the faculty of UT Southwestern. 

Dr. Banaszynski studies epigenetic contributions to gene expression and genome stability in mammalian systems. Her research focuses on the dynamic regulation of chromatin states at both coding and non-coding regions including the influence of histone variant incorporation on histone post-translational modification states. Her long-term goal is to improve our understanding of the chromatin-based mechanisms regulating fundamental cell-fate decisions in pluripotency and differentiation that are essential to our understanding of developmental processes.

Research Interest

  • Chromatin Biology
  • Developmental Gene Regulation
  • Histone Variants
  • Stem Cells

Publications

Featured Publications LegendFeatured Publications

Analysis of histones and chromatin in Xenopus laevis egg and oocyte extracts.
Banaszynski LA, Allis CD, Shechter D Methods 2010 May 51 1 3-10
A general method for conditional regulation of protein stability in living animals.
Sellmyer MA, Thorne SH, Banaszynski LA, Contag CH, Wandless TJ Cold Spring Harb Protoc 2009 Mar 2009 3 pdb.prot5173
Regulating protein stability in mammalian cells using small molecules.
Hagan EL, Banaszynski LA, Chen LC, Maynard-Smith LA, Wandless TJ Cold Spring Harb Protoc 2009 Mar 2009 3 pdb.prot5172
Recent progress with FKBP-derived destabilizing domains.
Chu BW, Banaszynski LA, Chen LC, Wandless TJ Bioorg. Med. Chem. Lett. 2008 Nov 18 22 5941-4
Chemical control of protein stability and function in living mice.
Banaszynski LA, Sellmyer MA, Contag CH, Wandless TJ, Thorne SH Nat. Med. 2008 Oct 14 10 1123-7
Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains.
Grimley JS, Chen DA, Banaszynski LA, Wandless TJ Bioorg. Med. Chem. Lett. 2008 Jan 18 2 759-61
A directed approach for engineering conditional protein stability using biologically silent small molecules.
Maynard-Smith LA, Chen LC, Banaszynski LA, Ooi AG, Wandless TJ J. Biol. Chem. 2007 Aug 282 34 24866-72
SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes.
Berdeaux R, Goebel N, Banaszynski L, Takemori H, Wandless T, Shelton GD, Montminy M Nat. Med. 2007 May 13 5 597-603
Conditional control of protein function.
Banaszynski LA, Wandless TJ Chem. Biol. 2006 Jan 13 1 11-21
Characterization of the FKBP.rapamycin.FRB ternary complex.
Banaszynski LA, Liu CW, Wandless TJ J. Am. Chem. Soc. 2005 Apr 127 13 4715-21

Honors & Awards

  • Cancer Prevention Research Institute of Texas First Time Faculty Recruitment Award
    (2014-2018)
  • American Chemical Society Nobel Laureate Signature Award for Graduate Education in Chemistry
    (2009)
  • Damon Runyon Cancer Research Foundation Postdoctoral Fellowship
    Angelo Family Fellow (2008-2011)