Laura Banaszynski is an Assistant Professor in the Department of Obstetrics and Gynecology and Children's Research Institute. She is a member of the Cecil H. and Ida Green Center for Reproductive Biology Sciences.
Dr. Banaszynski received her BS in Chemistry from The University of Notre Dame. She completed her PhD in Chemical & Systems Biology with Tom Wandless at Stanford University. She was then a Damon Runyon postdoctoral fellow with David Allis at The Rockefeller University. In 2015, Dr. Banaszynski joined the faculty of UT Southwestern.
Dr. Banaszynski studies epigenetic contributions to gene expression and genome stability in mammalian systems. Her research focuses on the dynamic regulation of chromatin states at both coding and non-coding regions including the influence of histone variant incorporation on histone post-translational modification states. Her long-term goal is to improve our understanding of the chromatin-based mechanisms regulating fundamental cell-fate decisions in pluripotency and differentiation that are essential to our understanding of developmental processes.
- Chromatin Biology
- Developmental Gene Regulation
- Histone Variants
- Stem Cells
- ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.
- Teng YC, Sundaresan A, O'Hara R, Gant VU, Li M, Martire S, Warshaw JN, Basu A, Banaszynski LA, Nat Commun 2021 06 12 1 3887
- The roles of histone variants in fine-tuning chromatin organization and function.
- Martire S, Banaszynski LA, Nat Rev Mol Cell Biol 2020 09 21 9 522-541
- Phosphorylation of histone H3.3 at serine 31 promotes p300 activity and enhancer acetylation.
- Martire S, Gogate AA, Whitmill A, Tafessu A, Nguyen J, Teng YC, Tastemel M, Banaszynski LA, Nat. Genet. 2019 Jun 51 6 941-946
- Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.
- Elsässer SJ, Noh KM, Diaz N, Allis CD, Banaszynski LA Nature 2015 May
- Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells.
- Banaszynski LA, Wen D, Dewell S, Whitcomb SJ, Lin M, Diaz N, Elsässer SJ, Chapgier A, Goldberg AD, Canaani E, Rafii S, Zheng D, Allis CD Cell 2013 Sep 155 1 107-20
- Distinct factors control histone variant H3.3 localization at specific genomic regions.
- Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, Boydston EA, Holmes MC, Gregory PD, Greally JM, Rafii S, Yang C, Scambler PJ, Garrick D, Gibbons RJ, Higgs DR, Cristea IM, Urnov FD, Zheng D, Allis CD Cell 2010 Mar 140 5 678-91
- Supporting women in academia during and after a global pandemic.
- Reese TA, Harris-Tryon TA, Gill JG, Banaszynski LA, Sci Adv 2021 Feb 7 9
- Establishment and function of chromatin modification at enhancers.
- Tafessu A, Banaszynski LA, Open Biol 2020 10 10 10 200255
- Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.
- Martire S, Nguyen J, Sundaresan A, Banaszynski LA, BMC Mol Cell Biol 2020 Jul 21 1 55
- Histone variant H3.3-mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos.
- Kong Q, Banaszynski LA, Geng F, Zhang X, Zhang J, Zhang H, O'Neill CL, Yan P, Liu Z, Shido K, Palermo GD, Allis CD, Rafii S, Rosenwaks Z, Wen D J. Biol. Chem. 2018 Jan
Honors & Awards
- ACS Research Scholar Award
- NETRF Peterson Research Investigator
- Cancer Prevention Research Institute of Texas First Time Faculty Recruitment Award
- American Chemical Society Nobel Laureate Signature Award for Graduate Education in Chemistry
- Damon Runyon Cancer Research Foundation Postdoctoral Fellowship
Angelo Family Fellow (2008-2011)