Laura Banaszynski is an Assistant Professor in the Department of Obstetrics and Gynecology and Children's Research Institute. She is a member of the Cecil H. and Ida Green Center for Reproductive Biology Sciences.
Dr. Banaszynski received her BS in Chemistry from The University of Notre Dame in 2000. She completed her PhD in Chemical & Systems Biology with Tom Wandless at Stanford University in 2007. From 2008-2014, she was a Damon Runyon postdoctoral fellow with David Allis at The Rockefeller University. In 2015, Dr. Banaszynski joined the faculty of UT Southwestern.
Dr. Banaszynski studies epigenetic contributions to gene expression and genome stability in mammalian systems. Her research focuses on the dynamic regulation of chromatin states at both coding and non-coding regions including the influence of histone variant incorporation on histone post-translational modification states. Her long-term goal is to improve our understanding of the chromatin-based mechanisms regulating fundamental cell-fate decisions in pluripotency and differentiation that are essential to our understanding of developmental processes.
- Chromatin Biology
- Developmental Gene Regulation
- Histone Variants
- Stem Cells
- Phosphorylation of histone H3.3 at serine 31 promotes p300 activity and enhancer acetylation.
- Martire S, Gogate AA, Whitmill A, Tafessu A, Nguyen J, Teng YC, Tastemel M, Banaszynski LA, Nat. Genet. 2019 Jun 51 6 941-946
- Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.
- Elsässer SJ, Noh KM, Diaz N, Allis CD, Banaszynski LA Nature 2015 May
- Histone variant H3.3 is an essential maternal factor for oocyte reprogramming.
- Wen D, Banaszynski LA, Liu Y, Geng F, Noh KM, Xiang J, Elemento O, Rosenwaks Z, Allis CD, Rafii S Proc. Natl. Acad. Sci. U.S.A. 2014 May 111 20 7325-30
- Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells.
- Banaszynski LA, Wen D, Dewell S, Whitcomb SJ, Lin M, Diaz N, Elsässer SJ, Chapgier A, Goldberg AD, Canaani E, Rafii S, Zheng D, Allis CD Cell 2013 Sep 155 1 107-20
- Histone variants in metazoan development.
- Banaszynski LA, Allis CD, Lewis PW Dev. Cell 2010 Nov 19 5 662-74
- Distinct factors control histone variant H3.3 localization at specific genomic regions.
- Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, Boydston EA, Holmes MC, Gregory PD, Greally JM, Rafii S, Yang C, Scambler PJ, Garrick D, Gibbons RJ, Higgs DR, Cristea IM, Urnov FD, Zheng D, Allis CD Cell 2010 Mar 140 5 678-91
- A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules.
- Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG, Wandless TJ Cell 2006 Sep 126 5 995-1004
- Genome editing a mouse locus encoding a variant histone, H3.3B, to report on its expression in live animals.
- Wen D, Noh KM, Goldberg AD, Allis CD, Rosenwaks Z, Rafii S, Banaszynski LA Genesis 2014 Dec 52 12 959-66
- H3.3 replacement facilitates epigenetic reprogramming of donor nuclei in somatic cell nuclear transfer embryos.
- Wen D, Banaszynski LA, Rosenwaks Z, Allis CD, Rafii S Nucleus 2014 Sep-Oct 5 5 369-75
- Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma.
- Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD Science 2013 Mar
Honors & Awards
- Cancer Prevention Research Institute of Texas First Time Faculty Recruitment Award
- American Chemical Society Nobel Laureate Signature Award for Graduate Education in Chemistry
- Damon Runyon Cancer Research Foundation Postdoctoral Fellowship
Angelo Family Fellow (2008-2011)