Biography

Dr. Weibo Luo is an Assistant Professor in the Departments of Pathology and Pharmacology at UT Southwestern Medical Center (UTSW) since December 2014. Dr. Luo received his Ph.D summa cum laude from the University of Magdeburg, Germany in 2007, completed his postdoctoral fellowship and instructorship with 2019 Nobel Laureate Dr. Gregg L. Semenza at the Johns Hopkins University School of Medicine before joining UTSW.

Dr. Luo studies oxygen homeostasis in tumor growth and metastasis at the molecular and cellular levels, with a particular focus on hypoxia-inducible factors (HIFs). He utilizes the multidisciplinary approaches to study crosstalk of HIF, epigenetics, and metabolism and their roles in tumor growth and metastasis. His overall goals are to identify the novel hypoxia-specific therapeutic targets and ultimately to translate knowledge to cancer therapy.

Research Interest

  • Epigenetics
  • Gene regulation
  • Hypoxia
  • Hypoxia-inducible factor
  • Metabolism
  • Tumor growth and metastasis

Publications

Featured Publications LegendFeatured Publications

PARP-1 and its associated nucleases in DNA damage response.
Wang Y, Luo W, Wang Y, DNA Repair (Amst.) 2019 Jul 102651
Hypoxia Mediates Tumor Malignancy and Therapy Resistance.
Luo W, Wang Y, Adv. Exp. Med. Biol. 2019 1136 1-18
Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-a protein stability and activity.
Luo W, Wang Y Cell. Mol. Life Sci. 2017 Oct
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.
Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B Immunity 2013 Aug 39 2 272-85

Honors & Awards

  • Mary Kay Foundation Research Award
    (2019)
  • Susan G. Komen Career Catalyst Research Award
    (2016)
  • Welch Foundation Research Award
    (2016)
  • American Cancer Society (ACS-IRG) New Investigator Awards in Cancer Research
    (2015)
  • CPRIT Scholar in Cancer Research
    Cancer Prevention Research Institute of Texas (2014)
  • AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award
    American Association for Cancer Research (2013)
  • NIH Pathway to Independence Award
    National Cancer Institute (2013)
  • Albert L. Lehninger Postdoctoral Research Award
    The Johns Hopkins University School of Medicine (2012)
  • FARMS Postdoctoral Fellowship
    Dr. Richard and Mavis Fowler Foundation for Advanced Research in the Medical Sciences, Inc (2011)
  • PhD summa cum laude
    University of Magdeburg, Germany (2007)

Professional Associations/Affiliations

  • American Association for Cancer Research (2011)