Weibo Luo, Ph.D. Associate Professor School Medical School Department Pathology | Pharmacology Graduate Programs Biological Chemistry, Cancer Biology Biography Dr. Weibo Luo is currently an Associate Professor of Pathology and Paharmacology. Dr. Luo received his Ph.D summa cum laude from the University of Magdeburg in Germany and completed his postdoctoral fellowship and instructorship at the Johns Hopkins University School of Medicine before joining UT Southwestern. Dr. Luo studies epigenetic and metabolic alterations through crosstalk with hypoxia in cancer development with the goal of identifiying vulnerability to treat human cancers. Research Interest Drug resistance Epigenetics Hypoxia/Hypoxia-inducible factor Immunotherapy Metabolism Tumor initiation, growth, and metastasis Publications Featured Publications ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2. Luo M, Bao L, Xue Y, Zhu M, Kumar A, Xing C, Wang JE, Wang Y, Luo W, J Clin Invest 2024 Jan 134 6 SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1. Bao L, Kumar A, Zhu M, Peng Y, Xing C, Wang JE, Wang Y, Luo W, J Clin Invest 2023 Sep 133 17 ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells. Luo M, Bao L, Chen Y, Xue Y, Wang Y, Zhang B, Wang C, Corley CD, McDonald JG, Kumar A, Xing C, Fang Y, Nelson ER, Wang JE, Wang Y, Luo W, Sci Adv 2022 07 8 28 eabn5295 Targeting BCAT1 combined with a-ketoglutarate triggers metabolic synthetic lethality in glioblastoma. Zhang B, Peng H, Zhou M, Bao L, Wang C, Cai F, Zhang H, Wang JE, Niu Y, Chen Y, Wang Y, Hatanpaa K, Copland JA, DeBerardinis RJ, Wang Y, Luo W, Cancer Res 2022 May ZMYND8 expression in breast cancer cells blocks T-lymphocyte surveillance to promote tumor growth. Wang Y, Luo M, Chen Y, Wang Y, Zhang B, Ren Z, Bao L, Wang Y, Wang JE, Fu YX, Luo W, Wang Y, Cancer Res 2020 Nov HIF-2-induced long non-coding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis. Niu Y, Bao L, Chen Y, Wang C, Luo M, Zhang B, Zhou M, Wang JE, Fang YV, Kumar A, Xing C, Wang Y, Luo W, Cancer Res. 2020 Jan Methylation of hypoxia-inducible factor (HIF)-1a by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W Nucleic Acids Res. 2018 May ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis. Chen Y, Zhang B, Bao L, Jin L, Yang M, Peng Y, Kumar A, Wang JE, Wang C, Zou X, Xing C, Wang Y, Luo W J. Clin. Invest. 2018 Apr Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL Cell 2011 May 145 5 732-44 KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response. Yang M, Wang C, Zhou M, Bao L, Wang Y, Kumar A, Xing C, Luo W, Wang Y, Nucleic Acids Res 2022 Jun 50 11 6313-6331 Results 1-10 of 21 1 2 3 Next Last Honors & Awards ACS Research Scholar (2021) Mary Kay Foundation Research Award (2019) Susan G. Komen Career Catalyst Research Award (2016) Welch Foundation Research Award (2016) American Cancer Society (ACS-IRG) New Investigator Awards in Cancer Research (2015) CPRIT Scholar in Cancer ResearchCancer Prevention Research Institute of Texas (2014) AACR-Bristol-Myers Squibb Oncology Scholar-in-Training AwardAmerican Association for Cancer Research (2013) NIH Pathway to Independence AwardNational Cancer Institute (2013) Albert L. Lehninger Postdoctoral Research AwardThe Johns Hopkins University School of Medicine (2012) FARMS Postdoctoral FellowshipDr. Richard and Mavis Fowler Foundation for Advanced Research in the Medical Sciences, Inc (2011) PhD summa cum laudeUniversity of Magdeburg, Germany (2007) Professional Associations/Affiliations American Association for Cancer Research (2011)
