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Jian Xu received his Ph.D. with Dr. Stephen Smale from UCLA, where he studied epigenetic regulation of stem cell pluripotency. Upon completion of his Ph.D. training in 2008, he earned a Helen Hay Whitney Foundation postdoctoral fellowship and joined Dr. Stuart Orkin’s laboratory at Boston Children’s Hospital, HHMI. In 2012, he became an instructor in Pediatric Hematology-Oncology at Harvard Medical School. In 2014, Dr. Xu received a first-time investigator award from the Cancer Prevention and Research Institute of Texas (CPRIT) and joined the faculty of the Children’s Medical Center Research Institute at UT Southwestern as an Assistant Professor in Pediatrics.

The Xu lab studies the gene regulatory processes that control stem cell development and how abnormalities cause blood disorders such as leukemia. They seek to advance our understanding of the principles of gene expression and regulation, particularly the mechanisms that control epigenetic regulators, metabolism and non-coding regulatory genome in normal and neoplastic blood cell development. Their studies promise to provide critical insights into developing novel therapeutic approaches for target-based cancer interventions.

Xu Laboratory


Fudan University (2000), Biochemistry
Graduate School
Uni of California (ucla) (2008), Molecular Biology

Research Interest

  • Epigenetic Regulation of Blood Stem Cell Development and Malignancies
  • Epigenetics and Metabolism
  • Functional Genomics and Bioinformatics
  • Gene Expression and Regulation
  • Hematopoiesis and Leukemia
  • Non-Coding Regulatory Genome


Featured Publications LegendFeatured Publications

Honors & Awards

  • Leukemia and Lymphoma Society Scholar
  • American Society of Hematology Scholar Award - Junior Faculty
  • CPRIT Scholar in Cancer Research
  • New Investigator Award, American Cancer Society/UT Southwestern
  • NIH/NIDDK Career Development Award (K01)
  • American Society of Hematology (ASH) Merit Award
  • American Society of Hematology (ASH) Merit Award
  • Helen Hay Whitney Foundation-HHMI Post-Doctoral Fellowship
  • California Institute for Regenerative Medicine (CIRM) Pre-Doctoral Fellowship

Professional Associations/Affiliations

  • International Society of Experimental Hematology (2017)
  • International Society for Stem Cell Research (2014)
  • American Society of Hematology (2008)