Biography

Dr. Silvia Ferrè is originally from Italy. She received her Ph.D. degree in medical sciences from Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands in 2013. During her Ph.D. training, she unraveled some of the molecular mechanisms that regulate magnesium reabsorption in the kidney by investigating genetic forms of hypomagnesemia. Drawn by the opportunity for the harmonious integration of nephrology, renal physiology, and molecular biology, she completed her postdoctoral fellowship with Dr. Peter Igarashi and Dr. Orson Moe at the Division of Nephrology and the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research here at UTSW. Dr. Ferrè's expertise spans from mineral metabolism and genetic diseases of the kidney to acute and chronic kidney injury models in vivo. She currently specializes in magnesium pathobiology in chronic kidney disease. Dr. Ferrè’s interests outside of science include running, biking, and hiking.

Research Interest

  • Bone and Mineral Metabolism
  • Chronic Kidney Disease
  • Genetic Diseases of the Kidney
  • Magnesium Pathobiology

Publications

Featured Publications LegendFeatured Publications

Association of serum magnesium with all-cause mortality in patients with and without chronic kidney disease in the Dallas Heart Study.
Ferrè S, Li X, Adams-Huet B, Maalouf NM, Sakhaee K, Toto RD, Moe OW, Neyra JA Nephrol. Dial. Transplant. 2017 Oct
Mutations in PCBD1 cause hypomagnesemia and renal magnesium wasting.
Ferrè S, de Baaij JH, Ferreira P, Germann R, de Klerk JB, Lavrijsen M, van Zeeland F, Venselaar H, Kluijtmans LA, Hoenderop JG, Bindels RJ J. Am. Soc. Nephrol. 2014 Mar 25 3 574-86
Early development of hyperparathyroidism due to loss of PTH transcriptional repression in patients with HNF1ß mutations?
Ferrè S, Bongers EM, Sonneveld R, Cornelissen EA, van der Vlag J, van Boekel GA, Wetzels JF, Hoenderop JG, Bindels RJ, Nijenhuis T J. Clin. Endocrinol. Metab. 2013 Oct 98 10 4089-96
Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease.
Sonneveld R, Ferrè S, Hoenderop JG, Dijkman HB, Berden JH, Bindels RJ, Wetzels JF, van der Vlag J, Nijenhuis T Am. J. Pathol. 2013 Apr 182 4 1196-204
Sensing mechanisms involved in Ca2+ and Mg2+ homeostasis.
Ferrè S, Hoenderop JG, Bindels RJ Kidney Int. 2012 Dec 82 11 1157-66
Role of the distal convoluted tubule in renal Mg2+ handling: molecular lessons from inherited hypomagnesemia.
Ferrè S, Hoenderop JJ, Bindels RJ Magnes Res 2011 Sep 24 3 S101-8
Insight into renal Mg2+ transporters.
Ferrè S, Hoenderop JG, Bindels RJ Curr. Opin. Nephrol. Hypertens. 2011 Mar 20 2 169-76
HNF-1B specifically regulates the transcription of the ?a-subunit of the Na+/K+-ATPase.
Ferrè S, Veenstra GJ, Bouwmeester R, Hoenderop JG, Bindels RJ Biochem. Biophys. Res. Commun. 2011 Jan 404 1 284-90
Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB.
Ferrè S, Baldoli E, Leidi M, Maier JA Biochim. Biophys. Acta 2010 Nov 1802 11 952-8
Magnesium deficiency and endothelial dysfunction: is oxidative stress involved?
Wolf FI, Trapani V, Simonacci M, Ferré S, Maier JA Magnes Res 2008 Mar 21 1 58-64

Honors & Awards

  • Ben J. Lipps Research Fellowship
    American Society of Nephrology (2014-2016)

Professional Associations/Affiliations

  • American Society of Nephrology (2013)