Jennifer Gill, M.D., Ph.D.

Dr. Gill received her M.D. and Ph.D. (Immunology) degrees from the Medical Scientist Training Program at Washington University Medical School in St. Louis. Prior to joining the faculty, she completed her dermatology residency and a cancer biology postdoctoral fellowship at the University of Texas Southwestern Medical Center. She is board-certified by the American Board of Dermatology and sees patients with melanoma and advanced skin cancer in her dermatology clinic at UTSW Professional Office Building 2.

In addition to clinical work, Dr. Gill runs a research laboratory focused on understanding the molecular and metabolic regulators of melanoma. Her specific interests include 1) Characterizing the role of the enzyme GAPDHS in melanoma progression and metastasis; 2) Determining how tumor metabolism impacts melanoma behavior, therapeutic response, and patient outcomes; and 3) Leveraging clinical and translational studies in patients to teach us about melanoma biology.

Medical School

Washington University School of Medicine (2012)

Graduate School

Washington University School of Medicine in St. Louis (2012)

Internship

Texas Health Presbyterian Hospital Dallas (2013), Internal Medicine

Residency

UT Southwestern Medical Center (2016), Dermatology

• Cancer metastasis
• Melanoma metastasis
• Targeted therapies for treatment of cancer

Featured Publications

Clinical Features and Outcomes of Black Patients with Melanoma.

Wix SN, Brown AB, Heberton M, Adamson AS, Gill JG, JAMA Dermatol 2024 Jan

Prevention of Skin Cancers With Topical Calcipotriol and Fluorouracil in Patients With Xeroderma Pigmentosum.

Kim J, Savory SA, Demehri S, Gill JG, JAMA Dermatol 2023 Feb 159 2 226-227

The mammalian SKIV2L RNA exosome is essential for early B cell development.

Yang K, Han J, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki C, de la Morena MT, Yan N, Sci Immunol 2022 Jun 7 72 eabn2888

A short isoform of spermatogenic enzyme GAPDHS functions as a metabolic switch and limits metastasis in melanoma.

Gill JG, Leef SN, Ramesh V, Martin-Sandoval MS, Rao AD, West L, Muh S, Gu W, Zhao Z, Hosler GA, Vandergriff TW, Durham AB, Mathews TP, Aurora AB, Cancer Res 2022 Feb

Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells.

Aurora AB, Khivansara V, Leach A, Gill JG, Martin-Sandoval M, Yang C, Kasitinon SY, Bezwada D, Tasdogan A, Gu W, Mathews TP, Zhao Z, DeBerardinis RJ, Morrison SJ, Proc Natl Acad Sci U S A 2022 02 119 6

Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease.

Yang K, Han J, Asada M, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki CA, de la Morena MT, Garza LA, Yan N, J Clin Invest 2022 Jan 132 2

Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients.

Frankel AE, Eskiocak U, Gill JG, Yuan S, Ramesh V, Froehlich TW, Ahn C, Morrison SJ Neoplasia 2017 Mar 19 4 255-260

Cancer, Oxidative Stress, and Metastasis.

Gill JG, Piskounova E, Morrison SJ Cold Spring Harb. Symp. Quant. Biol. 2017 Jan

Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma.

Eskiocak U, Ramesh V, Gill JG, Zhao Z, Yuan SW, Wang M, Vandergriff T, Shackleton M, Quintana E, Johnson TM, DeBerardinis RJ, Morrison SJ Nat Commun 2016 7 12336

Cutaneous manifestations of chemotherapeutic drugs

Gill JG and Dominguez A Current Dermatology Reports 2016 5 1

 Featured Books

Rituximab and Future Biologic Therapies. In Comprehensive Dermatologic Drug Therapy, 3rd Edition

Leonardi, CL, Heffernan, MP, and Gill, JG (2012). Saunders Publishing Company

• Doris Duke Clinician Scientist Development Award
  (2023)
• Disease Oriented Clinical Scholar (DOCS) Award
  (2022)
• American Academy of Dermatology Presidential Citation Award
  (2018)
• Dermatology Foundation Physician-Scientist Career Development Award
  (2017)
• Dermatologist Investigator Research Fellowship
  (2016)
• UTSW Dermatology Resident Award for Leadership
  (2016)
• Dermatology Resident Award for Humanism and Professionalism
  (2015)
• Texas Health Presbyterian Hospital Intern of the Year Award
  (2013)
• Barry M. Goldwater National Scholarship
  (2002)
• University of Georgia Foundation Fellowship Scholarship
  (1999-2003)

• American Academy of Dermatology (2013)
• American Association for Cancer Research (2023)
• Society for Investigative Dermatology (2013)
• Society for Melanoma Research (2021)