Dr. Evan Nair-Gill grew up in Madison, Wisconsin. He received his B.S. in biological chemistry from the University of Chicago and earned his M.D. and Ph.D. degrees from the University of California, Los Angeles. He completed his Ph.D. thesis in Dr. Owen Witte’s lab where he studied immune cell metabolism to develop imaging probes for non-invasive measurements of immune function. Evan moved to Dallas in 2013 to complete internal medicine residency and rheumatology fellowship at UT Southwestern. During fellowship, he worked in Dr. Bruce Beutler’s lab where he investigated the cellular mechanisms that control lymphocyte quiescence.
The Nair-Gill lab was established within the Center for the Genetics of Host Defense in 2021 with support from the Rheumatology Research Foundation, the National Institute for Allergy and Infectious Diseases, and the UT Southwestern Disease Oriented Clinical Scholar Award.
- Medical School
- UCLA School of Medicine (2013)
- UT Southwestern Medical Center (2015), Internal Medicine
- UT Southwestern Medical Center (2018), Rheumatology
- Cell competition in the hematopoietic system
- Lymphocyte quiescence and survival
- Lymphocyte signaling in autoimmunity and lymphoid malignancies
- Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases.
- Nair-Gill E, Bonora M, Zhong X, Liu A, Miranda A, Stewart N, Ludwig S, Russell J, Gallagher T, Pinton P, Beutler B, EMBO J 2021 Feb e104888
- RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice.
- Zhong X, Choi JH, Hildebrand S, Ludwig S, Wang J, Nair-Gill E, Liao TC, Moresco JJ, Liu A, Quan J, Sun Q, Zhang D, Zhan X, Choi M, Li X, Wang J, Gallagher T, Moresco EMY, Beutler B, Proc Natl Acad Sci U S A 2022 May 119 18 e2200128119
- Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.
- Zhong X, Su L, Yang Y, Nair-Gill E, Tang M, Anderton P, Li X, Wang J, Zhan X, Tomchick DR, Brautigam CA, Moresco EMY, Choi JH, Beutler B, Proc. Natl. Acad. Sci. U.S.A. 2020 Mar
- Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40.
- Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B, Nat. Immunol. 2019 Aug
- LMBR1L regulates lymphopoiesis through Wnt/?-catenin signaling.
- Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, Li X, Tang M, Sun Q, Yu L, Murray AR, Moresco EMY, Beutler B, Science 2019 05 364 6440
- Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene.
- McCracken MN, Gschweng EH, Nair-Gill E, McLaughlin J, Cooper AR, Riedinger M, Cheng D, Nosala C, Kohn DB, Witte ON, Proc Natl Acad Sci U S A 2013 Jan 110 5 1857-62
- PET probes for distinct metabolic pathways have different cell specificities during immune responses in mice.
- Nair-Gill E, Wiltzius SM, Wei XX, Cheng D, Riedinger M, Radu CG, Witte ON, J Clin Invest 2010 Jun 120 6 2005-15
Honors & Awards
- Disease Oriented Clinical Scholars (DOCS) Award
UT Southwestern Medical Center (2021)
- Tobe and Stephen Malawista Endowed Fellowship in Academic Rheumatology
The Rheumatology Research Foundation (2018-2021)
- Emil Bogan Award for Graduate Research
UC-Los Angeles (2013)
- Paul and Hisako Terasaki Endowed Fellowship
UC-Los Angeles (2011)