Biography

Dr. Chieko Mineo received both her B.S and Ph.D. in Pharmacology from University of Tokyo. She received post-doctoral training in Cell Biology at the University of Texas Southwestern Medical Center.

Dr. Mineo joined the faculty in the Department of Pediatrics at the University of Texas Southwestern Medical Center in 2002. She is a member of the Integrative Biology Graduate Program in the Division of Basic Science. 

Education

Undergraduate
University of Tokyo (1982), Pharmacology
Graduate School
University of Tokyo (1992), Pharmacology

Research Interest

  • Antiphospholipid Syndrome
  • Insulin resistance and endothelial dysfunction
  • Vascular Biology and Atherosclerosis

Publications

Featured Publications LegendFeatured Publications

Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: altered caveolar localization and impaired response to shear.
Joshi MS, Mineo C, Shaul PW, Bauer JA FASEB J. 2007 Sep 21 11 2655-63
Role of high-density lipoprotein and scavenger receptor B type I in the promotion of endothelial repair.
Mineo C, Shaul PW Trends Cardiovasc. Med. 2007 Jul 17 5 156-61
Direct Interactions with G alpha i and G betagamma mediate nongenomic signaling by estrogen receptor alpha.
Kumar P, Wu Q, Chambliss KL, Yuhanna IS, Mumby SM, Mineo C, Tall GG, Shaul PW Mol. Endocrinol. 2007 Jun 21 6 1370-80
C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice.
Schwartz R, Osborne-Lawrence S, Hahner L, Gibson LL, Gormley AK, Vongpatanasin W, Zhu W, Word RA, Seetharam D, Black S, Samols D, Mineo C, Shaul PW Circ. Res. 2007 May 100 10 1452-9
Endothelial and antithrombotic actions of HDL.
Mineo C, Deguchi H, Griffin JH, Shaul PW Circ. Res. 2006 Jun 98 11 1352-64
Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae.
Mineo C, Shaul PW Cardiovasc. Res. 2006 Apr 70 1 31-41
High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I.
Seetharam D, Mineo C, Gormley AK, Gibson LL, Vongpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW Circ. Res. 2006 Jan 98 1 63-72
FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase.
Mineo C, Gormley AK, Yuhanna IS, Osborne-Lawrence S, Gibson LL, Hahner L, Shohet RV, Black S, Salmon JE, Samols D, Karp DR, Thomas GD, Shaul PW Circ. Res. 2005 Nov 97 11 1124-31
Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling.
Assanasen C, Mineo C, Seetharam D, Yuhanna IS, Marcel YL, Connelly MA, Williams DL, de la Llera-Moya M, Shaul PW, Silver DL J. Clin. Invest. 2005 Apr 115 4 969-77
Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: role of ERalpha domains with known nuclear functions.
Chambliss KL, Simon L, Yuhanna IS, Mineo C, Shaul PW Mol. Endocrinol. 2005 Feb 19 2 277-89

Books

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Professional Associations/Affiliations

  • American Diabetes Association (2006)
  • American Heart Association (2004)