Biography

Dr. Chieko Mineo received both her B.S and Ph.D. in Pharmacology from University of Tokyo. She received post-doctoral training in Cell Biology at the University of Texas Southwestern Medical Center.

Dr. Mineo joined the faculty in the Department of Pediatrics at the University of Texas Southwestern Medical Center in 2002. She is a member of the Integrative Biology Graduate Program in the Division of Basic Science. 

Education

Undergraduate
University of Tokyo (1982), Pharmacology
Graduate School
University of Tokyo (1992), Pharmacology

Research Interest

  • Antiphospholipid Syndrome
  • Insulin resistance and endothelial dysfunction
  • Vascular Biology and Atherosclerosis

Publications

Featured Publications LegendFeatured Publications

Selective Non-nuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.
Selvaraj UM, Zuurbier K, Whoolery C, Plautz EJ, Chambliss KL, Kong X, Zhang S, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW, Stowe AM Endocrinology 2018 Sep
Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.
Sacharidou A, Chambliss KL, Ulrich V, Salmon JE, Shen YM, Herz J, Hui DY, Terada LS, Shaul PW, Mineo C Blood 2018 Mar
Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells.
Morel E, Ghezzal S, Lucchi G, Truntzer C, Pais de Barros JP, Simon-Plas F, Demignot S, Mineo C, Shaul PW, Leturque A, Rousset M, Carrière V Biochim. Biophys. Acta 2018 Feb 1863 2 199-211
Hyposialylated IgG activates endothelial IgG receptor Fc?RIIB to promote obesity-induced insulin resistance.
Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo C J. Clin. Invest. 2017 Nov
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.
Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul PW, Heeren J Nat. Med. 2017 Jun
New Insights in the Pathophysiology of Antiphospholipid Syndrome.
Sacharidou A, Shaul PW, Mineo C Semin. Thromb. Hemost. 2017 Jan
Non-Nuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.
Chambliss KL, Barrera J, Umetani M, Umetani J, Kim SH, Madak-Erdogan Z, Huang L, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW Endocrinology 2016 Aug en20151629
Endothelial Fc? Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice.
Tanigaki K, Chambliss KL, Yuhanna IS, Sacharidou A, Ahmed M, Atochin DN, Huang PL, Shaul PW, Mineo C Diabetes 2016 Apr
Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth.
Koo Y, Barry DM, Xu K, Tanigaki K, Davis GE, Mineo C, Cleaver O Angiogenesis 2016 Feb
Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.
Mineo C, Lanier L, Jung E, Sengupta S, Ulrich V, Sacharidou A, Tarango C, Osunbunmi O, Shen YM, Salmon JE, Brekken RA, Huang X, Thorpe PE, Shaul PW PLoS ONE 2016 11 7 e0158757

Books

Featured Books Legend Featured Books

Professional Associations/Affiliations

  • American Diabetes Association (2006)
  • American Heart Association (2004)