Christian Wysocki, M.D., Ph.D.

Christian A. Wysocki, M.D., Ph.D., is an Associate Professor in the departments of Internal Medicine and Pediatrics at UT Southwestern Medical Center. He serves as the Clinical Director of the Primary Immunodeficiency Program in the Division of Allergy and Immunology, a comprehensive clinical program dedicated to the diagnosis and multidisciplinary care of pediatric (and adult) patients with primary immunodeficiency disorders, in which he oversees the close collaboration of a number of disciplines, including bone marrow transplant, gastroenterology, rheumatology, hematology/oncology, infectious diseases, and basic immunology and translational research scientists.

Originally from Buffalo, New York, Dr. Wysocki holds a bachelor's degree in molecular biology and marine biology from the Florida Institute of Technology in Melbourne, Florida. He earned his medical degree and doctoral degree in microbiology and immunology at the University of North Carolina at Chapel Hill School of Medicine. He completed a residency in internal medicine at Yale University, where he also received advanced training through a fellowship in allergy and clinical immunology, with additional focused training in clinical immunology and primary immunodeficiency through the Clinical Immunology Society Summer School and USIDNET Visiting Immunology Scholars Program.

Certified by the American Board of Internal Medicine and the American Board of Allergy and Immunology, he joined the UT Southwestern faculty in 2013.

His ongoing research initiatives include a program directed at discovering new genetic abnormalities causing immunodeficiency or other immunologic disorders, which for Dr. Wysocki represents a longstanding collaboration with Nicolai Van Oers, Ph.D., in the Department of Immunology. He also works in concert with Dr. Van Oers on projects focused on the development of the thymus (a crucial organ in the development of the immune system) and genetic disorders that impact this process.

Other interests include collaborative projects focused on hemophagocytic lymphohistiocytosis (HLH) in both pediatric and adult patients, as well as projects focused on the autoimmune and inflammatory complications of common variable immunodeficiency (CVID).

Dr. Wysocki is a member of the American Academy of Allergy, Asthma, and Immunology and the Clinical Immunology Society. In addition, he serves as an immunologist consultant for the newborn screen lab for severe combined immunodeficiency (SCID) for the Texas Department of State Health Services.

Medical School

University of North Carolina at Chapel Hill (2007)

Residency

Yale University School of Medicine (2010), Internal Medicine

Internship

Yale New Haven Medical Center (2010), Internal Medicine

Fellowship

Yale University School of Medicine (2013), Allergy & Immunology

• Antiinflammatory Disorders
• Hemophagocytic Lymphohistiocytosis (HLH)
• Immune Dysregulation
• Primary Immunodeficiency
• Transplant Immunology

Featured Publications

SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency.

van Oers NSC, Hanners NW, Sue P, Aquino V, Li QZ, Schoggins JW, Wysocki CA, Clin Immunol 2021 Jan 108662

A late preterm infant with lymphopenia.

Lutfeali S, Khan DA, Wysocki C, Allergy Asthma Proc 2020 Mar 41 2 141-143

Molecular Insights Into the Causes of Human Thymic Hypoplasia With Animal Models.

Bhalla P, Wysocki CA, van Oers NSC, Front Immunol 2020 11 830

FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans.

Du Q, Huynh LK, Coskun F, Molina E, King MA, Raj P, Khan S, Dozmorov I, Seroogy CM, Wysocki CA, Padron GT, Yates TR, Markert ML, de la Morena MT, van Oers NS, J. Clin. Invest. 2019 Sep

Refractory macrophage activation syndrome in the setting of adult-onset Still disease with hemophagocytic lymphohistiocytosis detected on skin biopsy treated with canakinumab and tacrolimus.

Chamseddin B, Marks E, Dominguez A, Wysocki C, Vandergriff T, J Cutan Pathol 2019 Jul 46 7 528-531

In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease.

Morin-Zorman S, Wysocki C, Zhu J, Li H, Zorman S, Matte-Martone C, Kisanga E, McNiff J, Jain D, Gonzalez D, Rothstein DM, Lakkis FG, Haberman A, Shlomchik WD, Blood Adv 2019 07 3 14 2082-2092

Connecting the Dots From Fever of Unknown Origin to Myelodysplastic Syndrome: GATA2 Haploinsufficiency.

Montiel-Esparza R, Reys B, Rogers ZR, Evans AS, Wysocki CA, Timmons C, Dickerson KE, J. Pediatr. Hematol. Oncol. 2019 Apr

What's in a name? The heterogeneous clinical spectrum and prognostic factors in a cohort of adults with hemophagocytic lymphohistiocytosis.

Prokesch BC, Nagalla S, Ezzati F, Tujios SR, Dominguez A, Chen W, Kershaw C, Patel P, de la Flor C, Foster J, Martin AA, de la Morena MT, Wysocki CA Transfus. Apher. Sci. 2018 Oct

Novel nonsense gain-of-function NFKB2 mutations associated with a combined immunodeficiency phenotype.

Kuehn HS, Niemela JE, Sreedhara K, Stoddard JL, Grossman J, Wysocki CA, de la Morena MT, Garofalo M, Inlora J, Snyder MP, Lewis DB, Stratakis CA, Fleisher TA, Rosenzweig SD Blood 2017 08

Long term outcomes of 176 patients with X-linked hyper IgM syndrome treated with or without hematopoietic cell transplantation.

de la Morena MT, Leonard D, Torgerson TR, Cabral-Marques O, Slatter M, Aghamohammadi A, Chandra S, Murguia-Favela L, Bonilla F, Kanariou M, Damrongwatanasuk R, Kuo CY, Dvorak CC, Meyts I, Chen K, Kobrynski L, Kapoor N, Richter D, DiGiovanni D, Dhalla F, Farmaki E, Speckmann C, Espanol T, Shcherbina A, Hanson C, Litzman J, Routes J, Wong M, Fuleihan R, Seneviratne SL, Small TN, Janda A, Bezrodnik L, Seger R, Raccio AG, Edgar JD, Chou J, Abbott JK, van Montfrans J, Gonzalez-Granado LI, Bunin N, Kutukculer N, Gray P, Seminario G, Pasic S, Aquino V, Wysocki C, Abolhassani H, Grunebaum E, Dorsey M, Costa Carvalho BT, Condino-Neto A, Cunningham-Rundles C, Knutsen AP, Sleasman J, Chapel H, Ochs HD, Filipovich A, Cowan M, Gennery A, Cant A, Notarangelo LD, Roifman C J. Allergy Clin. Immunol. 2016 Sep

 Featured Books

Antigen Presentation and Antigen PResenting Cells in Graft-Versus-Host Disease. In Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Christian A. Wysocki and Warren D. Shlomchik (in press). Oxford, UK, Elsevier, Inc.

• Best Doctors in Dallas
  D Magazine (2019-2022)
• Director, Jeffrey Modell Diagnostic and Research Center
  Jeffrey Modell Foundation (2018)
• Expert Immunologist
  Jeffrey Modell Foundation (2017)
• Best Doctors in Dallas
  D Magazine (2016)
• Provider of the Year
  Yale Internal Medicine Residency Program (2010)
• Isaac Hall Manning Award
  University of North Carolina (2007)

• American Academy of Allergy, Asthma and Immunology
• Clinical Immunology Society