Christian Wysocki, M.D., Ph.D.

Christian A. Wysocki, M.D., Ph.D., is an Associate Professor in the departments of Internal Medicine and Pediatrics at UT Southwestern Medical Center. He serves as the Clinical Director of the Primary Immunodeficiency Program in the Division of Allergy and Immunology, a comprehensive clinical program dedicated to the diagnosis and multidisciplinary care of pediatric (and adult) patients with primary immunodeficiency disorders, in which he oversees the close collaboration of a number of disciplines, including bone marrow transplant, gastroenterology, rheumatology, hematology/oncology, infectious diseases, and basic immunology and translational research scientists.

Originally from Buffalo, New York, Dr. Wysocki holds a bachelor's degree in molecular biology and marine biology from the Florida Institute of Technology in Melbourne, Florida. He earned his medical degree and doctoral degree in microbiology and immunology at the University of North Carolina at Chapel Hill School of Medicine. He completed a residency in internal medicine at Yale University, where he also received advanced training through a fellowship in allergy and clinical immunology, with additional focused training in clinical immunology and primary immunodeficiency through the Clinical Immunology Society Summer School and USIDNET Visiting Immunology Scholars Program.

Certified by the American Board of Internal Medicine and the American Board of Allergy and Immunology, he joined the UT Southwestern faculty in 2013.

His ongoing research initiatives include a program directed at discovering new genetic abnormalities causing immunodeficiency or other immunologic disorders, which for Dr. Wysocki represents a longstanding collaboration with Nicolai Van Oers, Ph.D., in the Department of Immunology. He also works in concert with Dr. Van Oers on projects focused on the development of the thymus (a crucial organ in the development of the immune system) and genetic disorders that impact this process.

Other interests include collaborative projects focused on hemophagocytic lymphohistiocytosis (HLH) in both pediatric and adult patients, as well as projects focused on the autoimmune and inflammatory complications of common variable immunodeficiency (CVID).

Dr. Wysocki is a member of the American Academy of Allergy, Asthma, and Immunology and the Clinical Immunology Society. In addition, he serves as an immunologist consultant for the newborn screen lab for severe combined immunodeficiency (SCID) for the Texas Department of State Health Services.

Medical School

University of North Carolina at Chapel Hill (2007)

Internship

Yale New Haven Medical Center (2010), Internal Medicine

Residency

Yale University School of Medicine (2010), Internal Medicine

Fellowship

Yale University School of Medicine (2013), Allergy & Immunology

• Antiinflammatory Disorders
• Hemophagocytic Lymphohistiocytosis (HLH)
• Immune Dysregulation
• Primary Immunodeficiency
• Transplant Immunology

Featured Publications

Macrophage Activation Syndrome Complicated by Toxic Epidermal Necrolysis Following SARS-CoV-2 mRNA Vaccination.

Franzblau LE, Mauskar M, Wysocki CA, J Clin Immunol 2023 Apr 43 3 521-524

Epigenetic and Immunological Indicators of IPEX Disease in subjects with FOXP3 gene mutation.

Narula M, Lakshmanan U, Borna S, Schulze JJ, Holmes TH, Harre N, Kirkey M, Ramachandran A, Tagi VM, Barzaghi F, Grunebaum E, Upton JEM, Hong-Diep Kim V, Wysocki C, Dimitriades VR, Weinberg K, Weinacht KG, Gernez Y, Sathi BK, Schelotto M, Johnson M, Olek S, Sachsenmaier C, Roncarolo MG, Bacchetta R, J Allergy Clin Immunol 2022 Sep

Mesenchymal cell replacement corrects thymus hypoplasia in murine models of 22q11.2 deletion syndrome.

Bhalla P, Du Q, Kumar A, Xing C, Moses A, Dozmorov I, Wysocki CA, Cleaver OB, Pirolli TJ, Markert ML, de la Morena MT, Baldini A, van Oers NS, J Clin Invest 2022 Sep

The mammalian SKIV2L RNA exosome is essential for early B cell development.

Yang K, Han J, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki C, de la Morena MT, Yan N, Sci Immunol 2022 Jun 7 72 eabn2888

Obstructive hydrocephalus and intracerebral mass secondary to Epicoccum nigrum.

Charron TL, Gill MA, Filkins LM, Rajaram V, Wysocki CA, Whittemore BA, Med Mycol Case Rep 2022 Mar 35 18-21

Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease.

Yang K, Han J, Asada M, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki CA, de la Morena MT, Garza LA, Yan N, J Clin Invest 2022 Jan 132 2

Chronic Granulomatous Disease of the Upper Airway.

Bradshaw B, Jaffal H, Wysocki CA, Grover LA, Mitchell RB, Ulualp S, Shah GB, Chorney SR, Ear Nose Throat J 2021 Oct 1455613211054635

Lymphomatoid granulomatosis of the central nervous system (CNS-LYG) posing a management challenge.

Soleja M, Jaso JM, Chen W, Raisanen J, Wysocki CA, Shen YM, Mickey B, Kumar KA, Ramakrishnan Geethakumari P, Clin Case Rep 2021 Sep 9 9 e04808

SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency.

van Oers NSC, Hanners NW, Sue P, Aquino V, Li QZ, Schoggins JW, Wysocki CA, Clin Immunol 2021 Jan 108662

A late preterm infant with lymphopenia.

Lutfeali S, Khan DA, Wysocki C, Allergy Asthma Proc 2020 Mar 41 2 141-143

 Featured Books

Antigen Presentation and Antigen PResenting Cells in Graft-Versus-Host Disease. In Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Christian A. Wysocki and Warren D. Shlomchik (in press). Oxford, UK, Elsevier, Inc.

• Best Doctors in Dallas
  D Magazine (2019-2022)
• Director, Jeffrey Modell Diagnostic and Research Center
  Jeffrey Modell Foundation (2018)
• Expert Immunologist
  Jeffrey Modell Foundation (2017)
• Best Doctors in Dallas
  D Magazine (2016)
• Provider of the Year
  Yale Internal Medicine Residency Program (2010)
• Isaac Hall Manning Award
  University of North Carolina (2007)

• American Academy of Allergy, Asthma and Immunology
• Clinical Immunology Society