Biography

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Jessica Moreland received her Bachelor’s Degree in Zoology from Duke University.  She obtained her M.D. from Vanderbilt University in Nashville, Tennessee, in 1992.  Dr. Moreland remained at Vanderbilt University for her residency training in Pediatrics and her fellowship training in Pediatric Critical Care.  After completion of all of her postgraduate training, she was recruited to join the faculty at the University of Iowa.  Dr. Moreland was appointed as an Assistant Professor on the tenure track in 1998 and rose to the rank of Professor with Tenure in 2013. Her research focus has centered broadly on the theme of neutrophil-based inflammation.  While on faculty at the University of Iowa, Dr. Moreland served initially as the fellowship director for Pediatric Critical Care and served as the Division Director prior to joining UT Southwestern.  Dr. Moreland took over as the Division Chief of Pediatric Critical Care at UT Southwestern in January of 2014.  She is currently the Professor of Pediatrics and Microbiology and the Thomas Fariss Marsh, Jr. Chair in Pediatrics.

Education

Medical School
Vanderbilt University School of Medicine (1992)
Residency
Vanderbilt University Medical Center (1995), Pediatrics
Fellowship
Vanderbilt University Medical Center (1998), Pediatric Critical Care Medicine

Research Interest

  • Inflammation and the resolution of inflammation
  • Mechanisms of toll-like receptor signaling and role of single nucleotide polymorphisms
  • NADPH oxidase and reactive oxygen species signaling
  • Neutrophil priming
  • Translational analysis of neutrophil activation state during cardiopulmonary bypass and during chronic inflammatory disease

Publications

Featured Publications LegendFeatured Publications

ClC-3 and IClswell are required for normal neutrophil chemotaxis and shape change.
Volk AP, Heise CK, Hougen JL, Artman CM, Volk KA, Wessels D, Soll DR, Nauseef WM, Lamb FS, Moreland JG J. Biol. Chem. 2008 Dec 283 49 34315-26
Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent.
Matsuda JJ, Filali MS, Volk KA, Collins MM, Moreland JG, Lamb FS Am. J. Physiol., Cell Physiol. 2008 Jan 294 1 C251-62
Endotoxin priming of neutrophils requires NADPH oxidase-generated oxidants and is regulated by the anion transporter ClC-3.
Moreland JG, Davis AP, Matsuda JJ, Hook JS, Bailey G, Nauseef WM, Lamb FS J. Biol. Chem. 2007 Nov 282 47 33958-67
Pre-surgical evaluation of interrupted aortic arch with 3-dimensional reconstruction of CT images.
Morriss J, Moreland J, Burkhart H, Kao S Ann. Thorac. Surg. 2007 Jul 84 1 299
The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels.
Femling JK, Cherny VV, Morgan D, Rada B, Davis AP, Czirják G, Enyedi P, England SK, Moreland JG, Ligeti E, Nauseef WM, DeCoursey TE J. Gen. Physiol. 2006 Jun 127 6 659-72
Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration.
Moreland JG, Davis AP, Bailey G, Nauseef WM, Lamb FS J. Biol. Chem. 2006 May 281 18 12277-88
Neutrophil transendothelial migration in vitro to Streptococcus pneumoniae is pneumolysin dependent.
Moreland JG, Bailey G Am. J. Physiol. Lung Cell Mol. Physiol. 2006 May 290 5 L833-40
Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus.
Moreland JG, Bailey G, Nauseef WM, Weiss JP J. Immunol. 2004 Jan 172 1 426-32
CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease.
Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA Am. J. Respir. Cell Mol. Biol. 2002 Oct 27 4 474-80

Honors & Awards

  • Best Pediatric Specialists/Doctors in Dallas
    D Magazine (2015) (2018)
  • Election to American Pediatric Society
    (2013)
  • Best Doctors in America
    Best Doctors, Inc. (2012-2013)
  • Above and Beyond Award
    University of Iowa Health Care (2005-2006)
  • Election to Society for Pediatric Research
    (2001)
  • Elliot V. Newman Award
    Vanderbilt University Medical Center Research Forum (1997)
  • Amos Christie Award in Pediatrics
    Vanderbilt University Medical School (1995)
  • David Karzon Award
    Vanderbilt University, Department of Pediatrics (1995)
  • House Officer Research Award
    Society for Pediatric Research (1995)
  • 1992 Alpha Omega Alpha
    Alpha Omega Alpha Honor Medical Society (1992)

Professional Associations/Affiliations

  • American Academy of Pediatrics
  • American Pediatric Society
  • Society for Critical Care Medicine
  • Society for Leukocyte Biology
  • Society for Pediatric Research