Biography

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Jessica Moreland received her Bachelor’s Degree in Zoology from Duke University.  She obtained her M.D. from Vanderbilt University in Nashville, Tennessee, in 1992.  Dr. Moreland remained at Vanderbilt University for her residency training in Pediatrics and her fellowship training in Pediatric Critical Care.  After completion of all of her postgraduate training, she was recruited to join the faculty at the University of Iowa.  Dr. Moreland was appointed as an Assistant Professor on the tenure track in 1998 and rose to the rank of Professor with Tenure in 2013. Her research focus has centered broadly on the theme of neutrophil-based inflammation.  While on faculty at the University of Iowa, Dr. Moreland served initially as the fellowship director for Pediatric Critical Care and served as the Division Director prior to joining UT Southwestern.  Dr. Moreland took over as the Division Chief of Pediatric Critical Care at UT Southwestern in January of 2014.  She is currently the Professor of Pediatrics and Microbiology and the Thomas Fariss Marsh, Jr. Chair in Pediatrics.

Education

Medical School
Vanderbilt University School of Medicine (1992)
Residency
Vanderbilt University Medical Center (1995), Pediatrics
Fellowship
Vanderbilt University Medical Center (1998), Pediatric Critical Care Medicine

Research Interest

  • Inflammation and the resolution of inflammation
  • Mechanisms of toll-like receptor signaling and role of single nucleotide polymorphisms
  • NADPH oxidase and reactive oxygen species signaling
  • Neutrophil priming
  • Translational analysis of neutrophil activation state during cardiopulmonary bypass and during chronic inflammatory disease

Publications

Featured Publications LegendFeatured Publications

ROS-containing endosomal compartments: implications for signaling.
Davis Volk AP, Moreland JG Meth. Enzymol. 2014 535 201-24
NOX2 Protects against Prolonged Inflammation, Lung Injury, and Mortality following Systemic Insults.
Whitmore LC, Hilkin BM, Goss KL, Wahle EM, Colaizy TT, Boggiatto PM, Varga SM, Miller FJ, Moreland JG J Innate Immun 2013 Apr
Transepithelial migration of neutrophils into the lung requires TREM-1.
Klesney-Tait J, Keck K, Li X, Gilfillan S, Otero K, Baruah S, Meyerholz DK, Varga SM, Knudson CJ, Moninger TO, Moreland J, Zabner J, Colonna M J. Clin. Invest. 2013 Jan 123 1 138-49
Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species.
Lamb FS, Hook JS, Hilkin BM, Huber JN, Volk AP, Moreland JG J. Biol. Chem. 2012 Apr 287 15 12395-404
Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-a is partially oxygen dependent.
Volk AP, Barber BM, Goss KL, Ruff JG, Heise CK, Hook JS, Moreland JG J Innate Immun 2011 3 3 298-314
Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis.
McCaffrey RL, Schwartz JT, Lindemann SR, Moreland JG, Buchan BW, Jones BD, Allen LA J. Leukoc. Biol. 2010 Oct 88 4 791-805
Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production.
Matsuda JJ, Filali MS, Moreland JG, Miller FJ, Lamb FS J. Biol. Chem. 2010 Jul 285 30 22864-73
Francisella tularensis directly interacts with the endothelium and recruits neutrophils with a blunted inflammatory phenotype.
Moreland JG, Hook JS, Bailey G, Ulland T, Nauseef WM Am. J. Physiol. Lung Cell Mol. Physiol. 2009 Jun 296 6 L1076-84
Electrophysiology of reactive oxygen production in signaling endosomes.
Lamb FS, Moreland JG, Miller FJ Antioxid. Redox Signal. 2009 Jun 11 6 1335-47
ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells.
Drake JM, Strohbehn G, Bair TB, Moreland JG, Henry MD Mol. Biol. Cell 2009 Apr 20 8 2207-17

Honors & Awards

  • Best Pediatric Specialists/Doctors in Dallas
    D Magazine (2015) (2018)
  • Election to American Pediatric Society
    (2013)
  • Best Doctors in America
    Best Doctors, Inc. (2012-2013)
  • Above and Beyond Award
    University of Iowa Health Care (2005-2006)
  • Election to Society for Pediatric Research
    (2001)
  • Elliot V. Newman Award
    Vanderbilt University Medical Center Research Forum (1997)
  • Amos Christie Award in Pediatrics
    Vanderbilt University Medical School (1995)
  • David Karzon Award
    Vanderbilt University, Department of Pediatrics (1995)
  • House Officer Research Award
    Society for Pediatric Research (1995)
  • 1992 Alpha Omega Alpha
    Alpha Omega Alpha Honor Medical Society (1992)

Professional Associations/Affiliations

  • American Academy of Pediatrics
  • American Pediatric Society
  • Society for Critical Care Medicine
  • Society for Leukocyte Biology
  • Society for Pediatric Research