Biography

Download Curriculum Vitae

Education:
The University of Illinois (Champaign-Urbana)
BS, Biochemistry
BS, Genetics and Development
8/1984 - 5/1989

Duke University (Durham, NC)
PhD, Biochemistry
Vann Bennett, mentor
8/1989-5/1995

Post-Graduate Positions:
Postdoctoral Fellow, Dr. Vann Bennett, PI
Duke University (Durham, NC) 5/1995-2/1996

Postdoctoral Fellow, Dr. Richard Anderson, PI
UT Southwestern
2/1996-8/2002

Instructor, Department of Cell Biology
UT Southwestern
8/2002-8/2005

Assistant Professor, Department of Cell Biology
UT Southwestern
8/2005-present

Education

Undergraduate
Univ of Illinois @ Urbana-Cham (1989), Biochemistry
Graduate School
Duke University (1995), Biochemistry

Research Interest

  • Cancer biology - Role of cavin adaptors in signal transduction
  • Choleolerol homeostasis - LDLR mediated lipoprotein uptake
  • Nanosprings - use of ankyrin repeats to make nanospring nanodevices

Publications

Featured Publications LegendFeatured Publications

TGF-ß/ß2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.
Chen J, Yao ZX, Chen JS, Gi YJ, Muñoz NM, Kundra S, Herlong HF, Jeong YS, Goltsov A, Ohshiro K, Mistry NA, Zhang J, Su X, Choufani S, Mitra A, Li S, Mishra B, White J, Rashid A, Wang AY, Javle M, Davila M, Michaely P, Weksberg R, Hofstetter WL, Finegold MJ, Shay JW, Machida K, Tsukamoto H, Mishra L J. Clin. Invest. 2016 Feb 126 2 527-542
Quantitative Fluorescence Co-localization to Study Protein-Receptor Complexes.
Pompey SN, Michaely P, Luby-Phelps K Methods Mol. Biol. 2013 1008 439-53
Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR.
Michaely P, Zhao Z, Li WP, Garuti R, Huang LJ, Hobbs HH, Cohen JC EMBO J. 2007 Jul 26 14 3273-82
Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia.
Jones C, Garuti R, Michaely P, Li WP, Maeda N, Cohen JC, Herz J, Hobbs HH J. Clin. Invest. 2007 Jan 117 1 165-74
Nanospring behaviour of ankyrin repeats.
Lee G, Abdi K, Jiang Y, Michaely P, Bennett V, Marszalek PE Nature 2006 Mar 440 7081 246-9
Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake.
Yu L, Bharadwaj S, Brown JM, Ma Y, Du W, Davis MA, Michaely P, Liu P, Willingham MC, Rudel LL J. Biol. Chem. 2006 Mar 281 10 6616-24
The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits.
Garuti R, Jones C, Li WP, Michaely P, Herz J, Gerard RD, Cohen JC, Hobbs HH J. Biol. Chem. 2005 Dec 280 49 40996-1004
The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits.
Michaely P, Li WP, Anderson RG, Cohen JC, Hobbs HH J. Biol. Chem. 2004 Aug 279 32 34023-31
Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B.
Mohler PJ, Davis JQ, Davis LH, Hoffman JA, Michaely P, Bennett V J. Biol. Chem. 2004 Mar 279 13 12980-7
Crystal structure of a 12 ANK repeat stack from human ankyrinR.
Michaely P, Tomchick DR, Machius M, Anderson RG EMBO J. 2002 Dec 21 23 6387-96

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology (2007)
  • American Heart Association (2006)