Nisha Unni, M.D. Titles and Appointments Associate Professor School Medical School Department Internal Medicine You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Nisha Unni, M.D, is an Associate Professor of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Hematology and Oncology. She specializes in breast cancer. Dr. Unni earned her medical degree from the University of Kerala, Government Medical College, in India. After completing an internal medicine residency at Saint Vincent Hospital, a teaching affiliate of the University of Massachusetts, she performed a clinical fellowship in transfusion medicine and blood banking at the Yale University School of Medicine – Yale New Haven Hospital, followed by a clinical fellowship in hematology and oncology at the University of Medicine and Dentistry of New Jersey – Robert Wood Johnson Medical School, where she served as Chief Fellow. Board certified in internal medicine, hematology, and medical oncology, she joined the UT Southwestern faculty in 2013. She is a member of the American College of Physicians, the American Society of Clinical Oncology. Her research interests include endocrine therapy resistance in hormone receptor positive breast cancer and targeted therapies. Dr. Unni’s interests outside of medicine include spending time with her family, traveling, reading, and enjoying the great outdoors. Education Medical School Trivandrum Medical College, India (2003) Residency Saint Vincent Hospital (2009), Internal Medicine Fellowship Yale New Haven Hospital (2010), Blood Banking/transfusion Medicine Fellowship UMDNJ-Robert Wood Johnson Medical School (2013), Hematology Oncology Research Interest Clinical trials HER-2/neu positive breast cancer Hormone-receptor positive breast cancer, endocrine therapy resistance Targeted therapies in breast cancer Triple negative breast cancer Publications Featured Publications ESR1 Y537S and D538G mutations drive resistance to CDK4/6 inhibitors in estrogen receptor-positive breast cancer. Lin CA, Chica-Parrado MR, Unni N, Jaeger E, Fang YV, Guo L, Napolitano F, Luna P, Harris M, Chao C, Xu L, Arteaga CL, Hanker AB, Clin Cancer Res 2025 Feb Neratinib Efficacy in Patients With EGFR Exon 18-Mutant Non-Small-Cell Lung Cancer: Findings From the SUMMIT Basket Trial. Goldman JW, Bueno AM, Dooms C, Jhaveri K, de Miguel M, Piha-Paul SA, Unni N, Zick A, Mahipal A, Suga JM, Naltet C, Antoñanzas M, Crown J, Bebchuk J, Eli LD, Lowenthal BH, Mahalingam D, Clin Lung Cancer 2024 Dec Mapping cellular interactions from spatially resolved transcriptomics data. Zhu J, Wang Y, Chang WY, Malewska A, Napolitano F, Gahan JC, Unni N, Zhao M, Yuan R, Wu F, Yue L, Guo L, Zhao Z, Chen DZ, Hannan R, Zhang S, Xiao G, Mu P, Hanker AB, Strand D, Arteaga CL, Desai N, Wang X, Xie Y, Wang T, Nat Methods 2024 Sep A Tale of Two Hospitals: Effect of Access to Care Through a Safety Net Hospital on Adjuvant Therapy, Imaging Compliance and 5-Year Survival Rates Compared to the University Hospital Served by the Same Breast Cancer Clinical Teams. Mootz AR, Ozcan BB, Polat DS, Acevedo Z, Xi Y, Unni N, Nwachukwu C, Dogan BE, Acad Radiol 2024 Feb Mapping Cell-to-cell Interactions from Spatially Resolved Transcriptomics Data. Zhu J, Wang Y, Chang WY, Malewska A, Napolitano F, Gahan JC, Unni N, Zhao M, Wu F, Yue L, Guo L, Zhao Z, Chen DZ, Hannan R, Zhang S, Xiao G, Mu P, Hanker AB, Strand D, Arteaga CL, Desai N, Wang X, Xie Y, Wang T, bioRxiv 2023 Sep Aspirin use is associated with improvement in distant metastases outcome in patients with residual disease after neoadjuvant chemotherapy. Johns C, Montalvo SK, Cauble M, Liu YL, All S, Rahimi AS, Alluri PG, Leitch M, Unni N, Wooldridge R, Farr D, Nwachukwu C, Kim DWN, Breast Cancer Res Treat 2023 Jun 199 2 381-387 The Utility of Breast Cancer Index (BCI) Over Clinical Prognostic Tools for Predicting the Need for Extended Endocrine Therapy: A Safety Net Hospital Experience. Shah S, Shaing C, Khatib J, Lodrigues W, Dreadin-Pulliam J, Anderson BB, Unni N, Farr D, Li HC, Sadeghi N, Syed S, Clin Breast Cancer 2022 Aug Clinicopathological Features and Outcomes in Individuals with Breast Cancer and ATM, CHEK2, or PALB2 Mutations. Bergstrom C, Pence C, Berg J, Partain N, Sadeghi N, Mauer C, Pirzadeh-Miller S, Gao A, Li H, Unni N, Syed S, Ann Surg Oncol 2021 Jun 28 6 3383-3393 A Phase I/Ib Trial of PD 0332991 (Palbociclib) and T-DM1 in HER2-Positive Advanced Breast Cancer After Trastuzumab and Taxane Therapy. Haley B, Batra K, Sahoo S, Froehlich T, Klemow D, Unni N, Ahn C, Rodriguez M, Hullings M, Frankel AE, Clin Breast Cancer 2021 Mar Effect of Doxorubicin on Myocardial Bicarbonate Production From Pyruvate Dehydrogenase in Women With Breast Cancer. Park JM, Reed GD, Liticker J, Putnam WC, Chandra A, Yaros K, Afzal A, MacNamara J, Raza J, Hall RG, Baxter J, Derner K, Pena S, Kallem RR, Subramaniyan I, Edpuganti V, Harrison CE, Muthukumar A, Lewis C, Reddy S, Unni N, Klemow D, Syed S, Li H, Cole S, Froehlich T, Ayers C, de Lemos J, Malloy CR, Haley B, Zaha VG, Circ Res 2020 12 127 12 1568-1570 Results 1-10 of 21 1 2 3 Next Last Honors & Awards Eugene P. Frenkel, M.D. Outstanding Teacher AwardUTSW Hematology & Oncology Fellowship Program (2024) Eugene P. Frenkel, M.D. Outstanding Teacher AwardUTSW Hematology & Oncology Fellowship Program (2014) Professional Associations/Affiliations American College of Physicians (2007-2010) American Society of Hematology (2011) American Society of Oncology (2011) Hemostasis & Thrombosis Research Society (2012-2013)
