Biography

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Carole Mendelson received a B.S. in Biology from the City College of New York and a Ph.D. in Zoology from Rutgers University, New Brunswick, N.J. She spent five years as a postdoctoral and then Staff Fellow at the National Institutes of Health in Bethesda, Maryland. She joined the faculty of UT Southwestern in 1978. Research in the Mendelson laboratory is focused on reproductive and perinatal biology and includes: (1) genetic and epigenetic mechanisms in the developmental, hormonal and tissue-specific regulation of the gene encoding SP-A, the major protein of pulmonary surfactant; (2) transcriptional regulation of aromatase (CYP19) gene expression in estrogen-producing tissues and in pathologic states, including endometriosis, cancer and preeclampsia; (3) regulatory mechanisms involved in maintenance of uterine quiescence during pregnancy and activation of contractile genes leading to term and pre-term labor. Dr. Mendelson’s research is funded by the National Institutes of Health and The Burroughs Wellcome Foundation. She held an NIH MERIT Award from 1998 – 2008.

Dr. Mendelson served as a member of the Board of Scientific Counselors for the National Heart, Lung and Blood Institute, NIH, chaired the Reproductive Scientist Development Program Selection Committee and was a member of the Basil O’Connor Starter Scholar Research Award Advisory Committee. She is active within The Endocrine Society (TES), in which she has chaired a number of committees and served as a member of Council and as Vice President for Basic Scientists from 2008 – 2011. She was recently elected as Presidential nominee of the Society for Reproductive Investigation and will serve as President in 2021 - 2022. She also has been active in several committees that support the career advancement of women in science and medicine. She was president of Women in Endocrinology of TES. Within UT Southwestern, she co-chairs the Women in Science and Medicine Advisory Committee.

Education

Undergraduate
City College-Cuny (1964), Biology
Graduate School
Rutgers the State University (1970), Zoology

Research Interest

  • Mechanisms in the initiation of parturition
  • Molecular mechanisms in placental development
  • Molecular Mechanisms in the developmental, hormonal and tissue-specific regulation of surfactant protein gene expression in fetal lung tissue

Publications

Featured Publications LegendFeatured Publications

Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression.
Hardy DB, Janowski BA, Corey DR, Mendelson CR Mol. Endocrinol. 2006 Nov 20 11 2724-33
Permissive effects of oxygen on cyclic AMP and interleukin-1 stimulation of surfactant protein A gene expression are mediated by epigenetic mechanisms.
Islam KN, Mendelson CR Mol. Cell. Biol. 2006 Apr 26 8 2901-12
Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function.
Condon JC, Hardy DB, Kovaric K, Mendelson CR Mol. Endocrinol. 2006 Apr 20 4 764-75
Adenoviral-mediated gene delivery to trophoblast cells.
Jiang B, Mendelson CR Methods Mol. Med. 2006 121 451-61
O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated by proteasomal degradation of USF1 and USF2.
Jiang B, Mendelson CR Mol. Cell. Biol. 2005 Oct 25 20 8824-33
Temporal and spatial expression of liver receptor homologue-1 (LRH-1) during embryogenesis suggests a potential role in gonadal development.
Hinshelwood MM, Shelton JM, Richardson JA, Mendelson CR Dev. Dyn. 2005 Sep 234 1 159-68
Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids.
Janowski BA, Kaihatsu K, Huffman KE, Schwartz JC, Ram R, Hardy D, Mendelson CR, Corey DR Nat. Chem. Biol. 2005 Sep 1 4 210-5
Genomic regions that mediate placental cell-specific and developmental regulation of human Cyp19 (aromatase) gene expression in transgenic mice.
Kamat A, Smith ME, Shelton JM, Richardson JA, Mendelson CR Endocrinology 2005 May 146 5 2481-8
Transcriptional regulation of aromatase in placenta and ovary.
Mendelson CR, Jiang B, Shelton JM, Richardson JA, Hinshelwood MM J. Steroid Biochem. Mol. Biol. 2005 May 95 1-5 25-33
New insights into the molecular endocrinology of parturition.
Mendelson CR, Condon JC J. Steroid Biochem. Mol. Biol. 2005 Feb 93 2-5 113-9

Honors & Awards

  • Presidential Nominee (2019), Society for Reproductive investigation
    Officer in Scientific Society (2019-2020)
  • Sydney H. Ingbar Distinguished Service Award, The Endocrine Society
    Service Award (2019)
  • Frederick Naftolin Award for Mentorship, Society for Reproductive Investigation
    Mentorship Award (2017)
  • SGI-Pardi President's Distinguished Scientist Award, Society for Reproductive Investigation
    Award for Scientific Excellence (2014)
  • Mentor Award
    Women in Endocrinology (2010)
  • Vice-President, Basic Science
    The Endocrine Society (2008-2011)
  • Alpha Omega Alpha
    Honor Society (2002)
  • Roy O. Greep Award
    The Endocrine Society (2001)
  • NIH MERIT Award
    Regulation of SP-A Expression in Fetal Lung (1998-2008)