Carole Mendelson received a B.S. in Biology from the City College of New York and a Ph.D. in Zoology from Rutgers University, New Brunswick, N.J. She spent five years as a postdoctoral and then Staff Fellow at the National Institutes of Health in Bethesda, Maryland. She joined the faculty of UT Southwestern in 1978. Research in the Mendelson laboratory is focused on reproductive and perinatal biology and includes: (1) genetic and epigenetic mechanisms in the developmental, hormonal and tissue-specific regulation of the gene encoding SP-A, the major protein of pulmonary surfactant; (2) transcriptional regulation of aromatase (CYP19) gene expression in estrogen-producing tissues and in pathologic states, including endometriosis, cancer and preeclampsia; (3) regulatory mechanisms involved in maintenance of uterine quiescence during pregnancy and activation of contractile genes leading to term and pre-term labor. Dr. Mendelson’s research is funded by the National Institutes of Health and The Burroughs Wellcome Foundation. She held an NIH MERIT Award from 1998 – 2008.
Dr. Mendelson served as a member of the Board of Scientific Counselors for the National Heart, Lung and Blood Institute, NIH, chaired the Reproductive Scientist Development Program Selection Committee and was a member of the Basil O’Connor Starter Scholar Research Award Advisory Committee. She is active within The Endocrine Society (TES), in which she has chaired a number of committees and served as a member of Council and as Vice President for Basic Scientists from 2008 – 2011. She was recently elected as Presidential nominee of the Society for Reproductive Investigation and will serve as President in 2021 - 2022. She also has been active in several committees that support the career advancement of women in science and medicine. She was president of Women in Endocrinology of TES. Within UT Southwestern, she co-chairs the Women in Science and Medicine Advisory Committee.
- City College-Cuny (1964), Biology
- Graduate School
- Rutgers, the State Uni of Nj (1970), Zoology
- Mechanisms in the initiation of parturition
- Molecular mechanisms in placental development
- Molecular Mechanisms in the developmental, hormonal and tissue-specific regulation of surfactant protein gene expression in fetal lung tissue
- cAMP enhances estrogen-related receptor alpha (ERRalpha) transcriptional activity at the SP-A promoter by increasing its interaction with protein kinase A and steroid receptor coactivator 2 (SRC-2)
- Liu D, Benlhabib H, Mendelson CR Mol Endocrinol 2009 23 772-783
- Estrogen receptor alpha (ERalpha) mediates stimulatory effects of estrogen on aromatase (CYP19) gene expression in human placenta
- Kumar P, Kamat A, Mendelson CR Mol Endocrinol 2009 23 784-93
- Androstenedione up-regulation of endometrial aromatase expression via local conversion to estrogen: potential relevance to the pathogenesis of endometriosis.
- Bukulmez O, Hardy DB, Carr BR, Auchus RJ, Toloubeydokhti T, Word RA, Mendelson CR J. Clin. Endocrinol. Metab. 2008 Sep 93 9 3471-7
- TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity.
- Liu D, Yi M, Smith M, Mendelson CR Am. J. Physiol. Lung Cell Mol. Physiol. 2008 Aug 295 2 L264-71
- Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms.
- Hardy DB, Janowski BA, Chen CC, Mendelson CR Mol. Endocrinol. 2008 Aug 22 8 1812-24
- Inflammatory status influences aromatase and steroid receptor expression in endometriosis.
- Bukulmez O, Hardy DB, Carr BR, Word RA, Mendelson CR Endocrinology 2008 Mar 149 3 1190-204
- Glucocorticoid/glucocorticoid receptor inhibition of surfactant protein-A (SP-A) gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A promoter.
- Islam KN, Mendelson CR Mol. Endocrinol. 2008 Mar 22 3 585-96
- Progesterone receptor (PR) inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms
- Hardy DB, Janowski BA, Mendelson CR Mol Endocrinol 2008 22 1812-1824
- Progesterone receptor expression is a marker for early stage breast cancer: implications for progesterone receptor as a therapeutic tool and target.
- Coyle YM, Xie XJ, Hardy DB, Ashfaq R, Mendelson CR Cancer Lett. 2007 Dec 258 2 253-61
- Mechanisms in the regulation of aromatase in developing ovary and placenta.
- Mendelson CR, Kamat A J. Steroid Biochem. Mol. Biol. 2007 Aug-Sep 106 1-5 62-70
Honors & Awards
- President-Elect, Society for Reproductive Investigation
Society Leadership (2020-2021)
- Sydney H. Ingbar Distinguished Service Award, The Endocrine Society
Service Award (2019)
- Frederick Naftolin Award for Mentorship, Society for Reproductive Investigation
Mentorship Award (2017)
- SGI-Pardi President's Distinguished Scientist Award, Society for Reproductive Investigation
Award for Scientific Excellence (2014)
- Mentor Award, Women in Endocrinology
- Vice-President, Basic Science, The Endocrine Society
- Alpha Omega Alpha
Honor Society (2002)
- Roy O. Greep Award, The Endocrine Society
Scientific Excellence Award (2001)
- NIH MERIT Award
Regulation of SP-A Expression in Fetal Lung (1998-2008)