Carole Mendelson received a B.S. in Biology from the City College of New York and a Ph.D. in Zoology from Rutgers University, New Brunswick, N.J. She spent five years as a postdoctoral and then Staff Fellow at the National Institutes of Health in Bethesda, Maryland. She joined the faculty of UT Southwestern in 1978. Research in the Mendelson laboratory is focused on reproductive and perinatal biology and includes: (1) genetic and epigenetic mechanisms in the developmental, hormonal and tissue-specific regulation of the gene encoding SP-A, the major protein of pulmonary surfactant; (2) transcriptional regulation of aromatase (CYP19) gene expression in estrogen-producing tissues and in pathologic states, including endometriosis, cancer and preeclampsia; (3) regulatory mechanisms involved in maintenance of uterine quiescence during pregnancy and activation of contractile genes leading to term and pre-term labor. Dr. Mendelson’s research is funded by the National Institutes of Health and The Burroughs Wellcome Foundation. She held an NIH MERIT Award from 1998 – 2008.
Dr. Mendelson served as a member of the Board of Scientific Counselors for the National Heart, Lung and Blood Institute, NIH, chaired the Reproductive Scientist Development Program Selection Committee and was a member of the Basil O’Connor Starter Scholar Research Award Advisory Committee. She is active within The Endocrine Society (TES), in which she has chaired a number of committees and served as a member of Council and as Vice President for Basic Scientists from 2008 – 2011. She was recently elected as Presidential nominee of the Society for Reproductive Investigation and will serve as President in 2021 - 2022. She also has been active in several committees that support the career advancement of women in science and medicine. She was president of Women in Endocrinology of TES. Within UT Southwestern, she co-chairs the Women in Science and Medicine Advisory Committee.
- City College-Cuny (1964), Biology
- Graduate School
- Rutgers, the State Uni of Nj (1970), Zoology
- Mechanisms in the initiation of parturition
- Molecular mechanisms in placental development
- Molecular Mechanisms in the developmental, hormonal and tissue-specific regulation of surfactant protein gene expression in fetal lung tissue
- HUMAN TROPHOBLAST DIFFERENTIATION IS ASSOCIATED WITH PROFOUND GENE REGULATORY AND EPIGENETIC CHANGES.
- Kwak YT, Muralimanoharan S, Gogate AA, Mendelson CR, Endocrinology 2019 Jul
- Multifactorial Regulation of Myometrial Contractility During Pregnancy and Parturition.
- Mendelson CR, Gao L, Montalbano AP, Front Endocrinol (Lausanne) 2019 10 714
- Redox-Sensitive Transcription Factor NRF2 Enhances Trophoblast Differentiation via Induction of miR-1246 and Aromatase.
- Muralimanoharan S, Kwak YT, Mendelson CR Endocrinology 2018 Mar
- Cluster in Human Fetal Lung Promotes Type II Cell Differentiation by Upregulating Key Transcription Factors.
- Mishra R, Benlhabib H, Guo W, Lerma Cervantes CB, Mendelson CR Mol. Cell. Biol. 2018 Mar
- The transcriptional repressor GATAD2B mediates progesterone receptor suppression of myometrial contractile gene expression.
- Chen CC, Montalbano AP, Hussain I, Lee WR, Mendelson CR J. Biol. Chem. 2017 Jun
- miR-200 Regulates Endometrial Development During Early Pregnancy.
- Jimenez PT, Mainigi MA, Word RA, Kraus WL, Mendelson CR Mol. Endocrinol. 2016 Sep 30 9 977-87
- Fetal-to-maternal signaling in the timing of birth.
- Mendelson CR, Montalbano AP, Gao L J. Steroid Biochem. Mol. Biol. 2016 Sep
- Reciprocal Feedback between miR-181a and E2/ERa in Myometrium Enhances Inflammation Leading to Labor.
- Gao L, Wang G, Liu W, Kinser H, Franco HL, Mendelson CR J. Clin. Endocrinol. Metab. 2016 Jul jc20162078
- The miR-29 family promotes type II cell differentiation in developing lung.
- Guo W, Benlhabib H, Mendelson CR Mol. Cell. Biol. 2016 May
- Molecular Regulation of Parturition: A Myometrial Perspective.
- Renthal NE, Williams KC, Montalbano AP, Chen CC, Gao L, Mendelson CR Cold Spring Harb Perspect Med 2015 Sep
Honors & Awards
- President-Elect, Society for Reproductive Investigation
Society Leadership (2020-2021)
- Sydney H. Ingbar Distinguished Service Award, The Endocrine Society
Service Award (2019)
- Frederick Naftolin Award for Mentorship, Society for Reproductive Investigation
Mentorship Award (2017)
- SGI-Pardi President's Distinguished Scientist Award, Society for Reproductive Investigation
Award for Scientific Excellence (2014)
- Mentor Award, Women in Endocrinology
- Vice-President, Basic Science, The Endocrine Society
- Alpha Omega Alpha
Honor Society (2002)
- Roy O. Greep Award, The Endocrine Society
Scientific Excellence Award (2001)
- NIH MERIT Award
Regulation of SP-A Expression in Fetal Lung (1998-2008)