Biography

Theodore W. Laetsch, MD is an Associate Professor in the Department of Pediatrics and Member of the Harold C Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center in Dallas, TX. He also leads the Experimental and Cellular Therapeutics Program (ECTP) and the Cellular Therapeutics in the Gill Center for Cancer and Blood Disorders at Children’s Health. Dr. Laetsch also serves as the Rare Tumors Disease Committee Chair for the Children’s Oncology Group.  Dr. Laetsch received a BS in Agricultural and Biosystems Engineering from the University of Arizona and then a MD from the University of California, San Francisco. Dr. Laetsch completed his residency at the University of Colorado/Children’s Hospital Colorado, where he also served as chief resident. He completed his fellowship training and an instructorship at the Children's Hospital of Philadelphia (CHOP), where he conducted translational laboratory research focused on mechanisms to restore apoptotic signaling in neuroblastoma. In 2013, he joined the faculty at UT Southwestern. Dr. Laetsch conducts both early phase clinical and translational laboratory-based research testing potential novel therapeutics in high-risk pediatric solid tumors with a goal of “bridging the gap” between laboratory research and early phase clinical trials. As the leader of the ECTP program, Dr. Laetsch serves as the PI of several phase 1 and phase 2 studies of new targeted agents and cellular therapies for children with relapsed or refractory cancer. Dr. Laetsch has a strong interest in the use of tumor molecular profiling to guide therapy. In addition to these research activities, Dr. Laetsch continues to see children with cancer in the clinic at Children’s Medical Center.

Education

Medical School
University of California, San Francisco (2005)
Residency
University of Colorado - Children's Hospital Colorado - Pediatric Internship/Residency (2009), Pediatrics
Fellowship
Children's Hospital of Philadelphia - Pediatric Hema/Onco Fellowship (2012), Pediatric Hematology/oncology

Research Interest

  • Novel Therapeutics for Childhood Cancer
  • Tumor Genomic Profiling

Publications

Featured Publications LegendFeatured Publications

Target and Agent Prioritization for the Children's Oncology Group-National Cancer Institute Pediatric MATCH Trial.
Allen CE, Laetsch TW, Mody R, Irwin MS, Lim MS, Adamson PC, Seibel NL, Parsons DW, Cho YJ, Janeway K J. Natl. Cancer Inst. 2017 May 109 5
Targeting NTRK fusions for the treatment of congenital mesoblastic nephroma.
Laetsch TW, Nagasubramanian R, Casanova M Pediatr Blood Cancer 2017 Apr
Pediatric oncology enters an era of precision medicine.
Seibel NL, Janeway K, Allen CE, Chi SN, Cho YJ, Glade Bender JL, Kim A, Laetsch TW, Irwin MS, Takebe N, Tricoli JV, Parsons DW Curr Probl Cancer 2017 Feb
A case of advanced infantile myofibromatosis harboring a novel MYH10-RET fusion.
Rosenzweig M, Ali SM, Wong V, Schrock AB, Laetsch TW, Heilmann A, Morley S, Chudnovsky Y, Erlich RL, Wang K, Stephens PJ, Ross JS, Miller VA, Oesterheld J Pediatr Blood Cancer 2016 Dec
Drift correction for accurate PRF-shift MR thermometry during mild hyperthermia treatments with MR-HIFU.
Bing C, Staruch RM, Tillander M, Köhler MO, Mougenot C, Ylihautala M, Laetsch TW, Chopra R Int J Hyperthermia 2016 May 1-15
Pediatric Sarcomas Are Targetable by MR-Guided High Intensity Focused Ultrasound (MR-HIFU): Anatomical Distribution and Radiological Characteristics.
Shim J, Staruch RM, Koral K, Xie XJ, Chopra R, Laetsch TW Pediatr Blood Cancer 2016 May
Polyamine antagonist therapies inhibit neuroblastoma initiation and progression.
Evageliou NF, Haber M, Vu A, Laetsch TW, Murray J, Gamble LD, Cheng NC, Liu K, Reese M, Corrigan KA, Ziegler DS, Webber HT, Hayes CS, Pawel BR, Marshall GM, Zhao H, Gilmour SK, Norris MD, Hogarty MD Clin. Cancer Res. 2016 Mar
Potential pitfalls of mass spectrometry to uncover mutations in childhood soft tissue sarcoma: A report from the Children's Oncology Group.
Xu L, Wilson RA, Laetsch TW, Oliver D, Spunt SL, Hawkins DS, Skapek SX Sci Rep 2016 6 33429
Temperature-dependent MR signals in cortical bone: Potential for monitoring temperature changes during high-intensity focused ultrasound treatment in bone.
Ramsay E, Mougenot C, Kazem M, Laetsch TW, Chopra R Magn Reson Med 2014 Oct
Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma.
Laetsch TW, Liu X, Vu A, Sliozberg M, Vido M, Elci OU, Goldsmith KC, Hogarty MD Cell Death Dis 2014 5 e1072

Honors & Awards

  • Hyundai Scholar Research Award
    Hyundai Hope on Wheels (2018)
  • Physician of the Year
    Children's Health (2018)
  • Rising Star Award
    UT Southwestern Leaders in Clinical Excellence (2018)
  • Early Career Investigator Award
    Cold Spring Harbor (2016)
  • Research Award
    Rally Foundation for Childhood Cancer (2015)
  • Hyundai Young Investigator Research Award
    Hyundai Hope on Wheels (2014)
  • NICHD Child Health Research Career Development Award (K12)
    (2012)
  • Joseph W. St. Geme, Jr., M.D. Award for Outstanding Research as a Resident
    (2008)
  • Gold Headed Cane Society Member
    (2005)
  • Alpha Omega Alpha Member
    (2004)

Professional Associations/Affiliations

  • American Society of Hematology (2018)
  • Connective Tissue Oncology Society (2017)
  • International Society of Pediatric Oncology (2016)
  • Dallas Medical Society (2014)
  • Texas Medical Society (2014)
  • American Association for Cancer Research (2010)
  • American Society of Clinical Oncology (2010)
  • American Society of Pediatric Hematology/Oncology (2009)
  • Children's Oncology Group (2009)
  • American Academy of Pediatrics (2005-2008)