Biography

Theodore W. Laetsch, MD is an Associate Professor in the Department of Pediatrics and Member of the Harold C Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center in Dallas, TX. He also leads the Experimental and Cellular Therapeutics Program (ECTP) and the Cellular Therapeutics in the Gill Center for Cancer and Blood Disorders at Children’s Health. Dr. Laetsch also serves as the Rare Tumors Disease Committee Chair for the Children’s Oncology Group.  Dr. Laetsch received a BS in Agricultural and Biosystems Engineering from the University of Arizona and then a MD from the University of California, San Francisco. Dr. Laetsch completed his residency at the University of Colorado/Children’s Hospital Colorado, where he also served as chief resident. He completed his fellowship training and an instructorship at the Children's Hospital of Philadelphia (CHOP), where he conducted translational laboratory research focused on mechanisms to restore apoptotic signaling in neuroblastoma. In 2013, he joined the faculty at UT Southwestern. Dr. Laetsch conducts both early phase clinical and translational laboratory-based research testing potential novel therapeutics in high-risk pediatric solid tumors with a goal of “bridging the gap” between laboratory research and early phase clinical trials. As the leader of the ECTP program, Dr. Laetsch serves as the PI of several phase 1 and phase 2 studies of new targeted agents and cellular therapies for children with relapsed or refractory cancer. Dr. Laetsch has a strong interest in the use of tumor molecular profiling to guide therapy. In addition to these research activities, Dr. Laetsch continues to see children with cancer in the clinic at Children’s Medical Center.

Education

Medical School
University of California, San Francisco (2005)
Residency
University of Colorado - Children's Hospital Colorado - Pediatric Internship/Residency (2009), Pediatrics
Fellowship
Children's Hospital of Philadelphia - Pediatric Hema/Onco Fellowship (2012), Pediatric Hematology/oncology

Research Interest

  • Novel Therapeutics for Childhood Cancer
  • Tumor Genomic Profiling

Publications

Featured Publications LegendFeatured Publications

Undifferentiated sarcomas in children harbor clinically-relevant oncogenic fusions and gene copy-number alterations: A report from the Children's Oncology Group.
Laetsch TW, Roy A, Xu L, Black JO, Coffin CM, Chi YY, Tian J, Spunt SL, Hawkins DS, Bridge JA, Parsons DW, Skapek SX Clin. Cancer Res. 2018 Apr
Pan-Trk Immunohistochemistry Identifies NTRK rearrangements in Pediatric Mesenchymal Tumors.
Rudzinski ER, Lockwood CM, Stohr BA, Vargas SO, Sheridan R, Black JO, Rajaram V, Laetsch TW, Davis JL Am. J. Surg. Pathol. 2018 Apr
False-positive results following lentiviral-based tisagenlecleucel therapy with select HIV-1 NAT methods.
Laetsch TW, Maude SL, Milone MC, Davis KL, Krueger J, Cardenas AM, Eldjerou LK, Keir CH, Wood PA, Grupp SA Blood 2018 Apr
Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study.
Laetsch TW, DuBois SG, Mascarenhas L, Turpin B, Federman N, Albert CM, Nagasubramanian R, Davis JL, Rudzinski E, Feraco AM, Tuch BB, Ebata KT, Reynolds M, Smith S, Cruickshank S, Cox MC, Pappo AS, Hawkins DS Lancet Oncol. 2018 Mar
Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study.
Sun W, Malvar J, Sposto R, Verma A, Wilkes JJ, Dennis R, Heym K, Laetsch TW, Widener M, Rheingold SR, Oesterheld J, Hijiya N, Sulis ML, Huynh V, Place AE, Bittencourt H, Hutchinson R, Messinger Y, Chang B, Matloub Y, Ziegler DS, Gardner R, Cooper T, Ceppi F, Hermiston M, Dalla-Pozza L, Schultz KR, Gaynon P, Wayne AS, Whitlock JA Leukemia 2018 Mar
EGF Receptor and mTORC1 are novel therapeutic targets in nonseminomatous germ cell tumors.
Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF Mol. Cancer Ther. 2018 Feb
Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.
Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, Nathenson M, Doebele RC, Farago AF, Pappo AS, Turpin B, Dowlati A, Brose MS, Mascarenhas L, Federman N, Berlin J, El-Deiry WS, Baik C, Deeken J, Boni V, Nagasubramanian R, Taylor M, Rudzinski ER, Meric-Bernstam F, Sohal DPS, Ma PC, Raez LE, Hechtman JF, Benayed R, Ladanyi M, Tuch BB, Ebata K, Cruickshank S, Ku NC, Cox MC, Hawkins DS, Hong DS, Hyman DM N. Engl. J. Med. 2018 02 378 8 731-739
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.
Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, Bader P, Verneris MR, Stefanski HE, Myers GD, Qayed M, De Moerloose B, Hiramatsu H, Schlis K, Davis KL, Martin PL, Nemecek ER, Yanik GA, Peters C, Baruchel A, Boissel N, Mechinaud F, Balduzzi A, Krueger J, June CH, Levine BL, Wood P, Taran T, Leung M, Mueller KT, Zhang Y, Sen K, Lebwohl D, Pulsipher MA, Grupp SA N. Engl. J. Med. 2018 02 378 5 439-448
Redefining treatment failure for pediatric acute leukemia in the era of minimal residual disease testing.
Huynh V, Laetsch TW, Schore RJ, Gaynon P, O'Brien MM Pediatr Hematol Oncol 2017 Nov 1-14
Comprehensive Analysis of Hypermutation in Human Cancer.
Campbell BB, Light N, Fabrizio D, Zatzman M, Fuligni F, de Borja R, Davidson S, Edwards M, Elvin JA, Hodel KP, Zahurancik WJ, Suo Z, Lipman T, Wimmer K, Kratz CP, Bowers DC, Laetsch TW, Dunn GP, Johanns TM, Grimmer MR, Smirnov IV, Larouche V, Samuel D, Bronsema A, Osborn M, Stearns D, Raman P, Cole KA, Storm PB, Yalon M, Opocher E, Mason G, Thomas GA, Sabel M, George B, Ziegler DS, Lindhorst S, Issai VM, Constantini S, Toledano H, Elhasid R, Farah R, Dvir R, Dirks P, Huang A, Galati MA, Chung J, Ramaswamy V, Irwin MS, Aronson M, Durno C, Taylor MD, Rechavi G, Maris JM, Bouffet E, Hawkins C, Costello JF, Meyn MS, Pursell ZF, Malkin D, Tabori U, Shlien A Cell 2017 Oct

Honors & Awards

  • Hyundai Scholar Research Award
    Hyundai Hope on Wheels (2018)
  • Physician of the Year
    Children's Health (2018)
  • Rising Star Award
    UT Southwestern Leaders in Clinical Excellence (2018)
  • Early Career Investigator Award
    Cold Spring Harbor (2016)
  • Research Award
    Rally Foundation for Childhood Cancer (2015)
  • Hyundai Young Investigator Research Award
    Hyundai Hope on Wheels (2014)
  • NICHD Child Health Research Career Development Award (K12)
    (2012)
  • Joseph W. St. Geme, Jr., M.D. Award for Outstanding Research as a Resident
    (2008)
  • Gold Headed Cane Society Member
    (2005)
  • Alpha Omega Alpha Member
    (2004)

Professional Associations/Affiliations

  • American Society of Hematology (2018)
  • Connective Tissue Oncology Society (2017)
  • International Society of Pediatric Oncology (2016)
  • Dallas Medical Society (2014)
  • Texas Medical Society (2014)
  • American Association for Cancer Research (2010)
  • American Society of Clinical Oncology (2010)
  • American Society of Pediatric Hematology/Oncology (2009)
  • Children's Oncology Group (2009)
  • American Academy of Pediatrics (2005-2008)