David McFadden, M.D., Ph.D. - Faculty Profile

Biography

David McFadden, M.D., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Endocrinology. He holds a secondary appointment in the Department of Biochemistry. His clinical interests include the treatment of tumors arising from endocrine glands, particularly thyroid cancer.

Originally from Midland, Texas, Dr. McFadden holds a bachelor's degree in microbiology from Texas A&M University at College Station, where he graduated with honors. He obtained his medical degree and his doctoral degree in genetics at UT Southwestern. He then received internal medicine residency training at Brigham & Women's Hospital in Boston, followed by advanced training through a fellowship program in endocrinology and metabolism at Massachusetts General Hospital, where he was a member of the Center for Endocrine Tumors and a staff physician in the Thyroid Associates and Endocrine Tumor Genetics clinics.

Prior to joining the UT Southwestern faculty in 2015, he completed postdoctoral research at the Massachusetts Institute of Technology.

Dr. McFadden's research interests include using genetic engineering and chemical screens to discover new treatments for cancer. He has received research grants from the National Institutes of Health, American Thyroid Association, Cancer Prevention and Research Institute of Texas (CPRIT), and UT Southwestern's Disease Oriented Clinical Scholars (DOCS) program.

Dr. McFadden is an active member of the American Thyroid Association, the International Thyroid Oncology Group, and the American Association for Cancer Research.

Education

Medical School: UT Southwestern Medical School (2004)
Internship: Harvard/Brigham and Women's Hospital (2005), Internal Medicine
Residency: Harvard/Brigham and Women's Hospital (2006), Internal Medicine
Fellowship: Massachusetts General Hospital (2009), Endocrinology & Metabolism

Research Interest

Cancer Biology
Cancer Genetics
Targeted Therapies
Thyroid Cancer
Tumor Progression

Publications

Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase Inhibitors: Frank AR, Vandiver F, McFadden DG ACS chemical biology 2024 Feb 19 471-482
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules: Nguyen TP, Fang M, Kim J, Wang B, Lin E, Khivansara V, Barrows N, Rivera-Cancel G, Goralski M, Cervantes CL, Xie S, Peterson JM, Povedano JM, Antczak MI, Posner BA, Harvey CJ, Naughton BT, McFadden DG, Ready JM, De Brabander JK, Nijhawan D Cell Chemical Biology 2023 Nov 30 1453-1467.e8
Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid: Frank AR, Li V, Shelton SD, Kim J, Stott GM, Neckers LM, Xie Y, Williams NS, Mishra P, McFadden DG Cancer discovery 2023 Aug 13 1884-1903
Differential requirements for mitochondrial electron transport chain components in the adult murine liver: Lesner NP, Wang X, Chen Z, Frank A, Menezes C, House S, Shelton SD, Lemoff A, McFadden DG, Wansapura J, Deberardinis RJ, Mishra P eLife 2022 Sep 11
TK216 targets microtubules in Ewing sarcoma cells: Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG Cell Chemical Biology 2022 Aug 29 1325-1332.e4
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms: McFadden DG, Sadow PM Frontiers in Endocrinology 2021 Jun 12
Mitochondrial DNA Haplotypes as Genetic Modifiers of Cancer: Tasdogan A, McFadden DG, Mishra P Trends in Cancer 2020 Dec 6 1044-1058
A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins: Povedano JM, Rallabandi R, Bai X, Ye X, Liou J, Chen H, Kim J, Xie Y, Posner B, Rice L, De Brabander JK, McFadden DG Journal of Medicinal Chemistry 2020 Nov 63 14054-14066
New Approaches to SCLC Therapy: From the Laboratory to the Clinic: Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, Carbone D, Chen HJ, Christensen CL, Dive C, Farago AF, Govindan R, Hann C, Hellmann MD, Horn L, Johnson JE, Ju YS, Kang S, Krasnow M, Lee J, Lee SH, Lehman J, Lok B, Lovly C, MacPherson D, McFadden D, Minna J, Oser M, Park K, Park KS, Pommier Y, Quaranta V, Ready N, Sage J, Scagliotti G, Sos ML, Sutherland KD, Travis WD, Vakoc CR, Wait SJ, Wistuba I, Wong KK, Zhang H, Daigneault J, Wiens J, Rudin CM, Oliver TG Journal of Thoracic Oncology 2020 Apr 15 520-540
Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification: Povedano JM, Liou J, Wei D, Srivatsav A, Kim J, Xie Y, Nijhawan D, McFadden DG Cell Chemical Biology 2019 Sep 26 1315-1321.e3

Honors & Awards

Clinical Investigator Award
Damon Runyon Cancer Research Foundation (2019)
Synergy Grant Award
UT Southwestern Dean's Circle of Friends (2019)
CPRIT Scholar
UT Southwestern (2014)
Disease Oriented Clinical Scholar
UT Southwestern (2014)
"Rookie of the Year" Philanthropy Award
Massachusetts General Hospital (2013)
Scholar in Training Award
Bristol-Myers Squibb (2013)

Professional Associations/Affiliations

Alpha Omega Alpha Medical Honor Society
American Association for Cancer Research
American Thyroid Association
International Thyroid Oncology Group