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James P. McCulley, M.D. was born in Fort Worth, Texas, and received a bachelor’s degree from Texas Christian University (Alpha Chi Honor Society). He graduated from Washington University School of Medicine and was a member of AOA. He subsequently did a straight medical internship on the Harvard Medical Service at Boston City Hospital prior to five years of training at the Massachusetts Eye and Ear Infirmary (MEEI), which encompassed residency as well as a corneal fellowship. He is a Diplomat of the American Board of Ophthalmology, as well as a Fellow of the Royal College of Ophthalmology (U.K.). After leaving MEEI, he spent two years on staff at Bethesda Naval Hospital prior to joining the faculty of the Department of Ophthalmology at Stanford University Medical School. He moved to Dallas on the faculty at The University of Texas, Southwestern Medical School, in 1980 and became Professor and Chairman in 1981, a position that he currently holds. He has held positions in many different organizations including the presidency of the Castroviejo Society, secretary-treasurer of the Association of University Professors of Ophthalmology, member of several medical related boards, including the Eye Bank Association of American, Contact Lens Association of Ophthalmologists, and Center for Alternatives to Animal Testing at Johns Hopkins. He has served on both NIH and FDA Advisory Committees and chaired the FDA Ophthalmic Device Panel from 1999 to 2001 and the Vision A Study Section. He continues to serve as a consultant to the FDA. He also served on the Residency Review Committee for Ophthalmology from 1990 to 1996. He has served for many years as an associate examiner for the American Board of Ophthalmology. He has held multiple administrative positions at The University of Texas Southwestern Medical School including, Chairman of the Practice Plan Committee. He has received multiple honors over the years including the Honor and Senior Honor awards from the AAO and presented more than 140 invited lectureships and visiting professorships, received the Distinguished Alumnus Award from Texas Christian University and the Distinguished Alumni Award from Harvard Medical School (formerly Massachusetts Eye & Ear Infirmary) and been recognized as one of the "Best Ophthalmologists/Doctors" in many different publications. He has been principle investigator of an NEI/NIH grant since 1978. He has published more than 200 peer reviewed manuscripts, citable abstracts, books and book chapters.


Medical School
Washington University School of Medicine (1968)
Boston City Hospital (1969), Internal Medicine
Research Fellowship
Retina Foundation (1970), Cornea Research, Department of
Massachusetts Eye and Ear Infirmary (1973), Ophthalmology
Massachusetts Eye and Ear Infirmary (1974), Cornea & External Disease
Retina Foundation (1974), Cornea Research, Department of

Research Interest

  • Acanthamoeba Keratitis
  • Chronic Blepharitis
  • Corneal transplantation
  • Severe Infectious Disease
  • Tissue culture of endothelium and epithelium


Featured Publications LegendFeatured Publications

Characterization and pathogenic potential of a soil isolate and an ocular isolate of Acanthamoeba castellanii in relation to Acanthamoeba keratitis.
van Klink F, Alizadeh H, Stewart GL, Pidherney MS, Silvany RE, He Y, McCulley JP, Niederkorn JY Curr. Eye Res. 1992 Dec 11 12 1207-20
Continuous circular capsulorhexis.
McCulley JP, Dave AS Cornea 1992 Nov 11 6 604
Chemotactic response of macrophages to Acanthamoeba castellanii antigen and antibody-dependent macrophage-mediated killing of the parasite.
Stewart GL, Kim I, Shupe K, Alizadeh H, Silvany R, McCulley JP, Niederkorn JY J. Parasitol. 1992 Oct 78 5 849-55
A pig model of Acanthamoeba keratitis: transmission via contaminated contact lenses.
He YG, McCulley JP, Alizadeh H, Pidherney M, Mellon J, Ubelaker JE, Stewart GL, Silvany RE, Niederkorn JY Invest. Ophthalmol. Vis. Sci. 1992 Jan 33 1 126-33
Susceptibility of corneas from various animal species to in vitro binding and invasion by Acanthamoeba castellanii [corrected].
Niederkorn JY, Ubelaker JE, McCulley JP, Stewart GL, Meyer DR, Mellon JA, Silvany RE, He YG, Pidherney M, Martin JH Invest. Ophthalmol. Vis. Sci. 1992 Jan 33 1 104-12
In vitro transfer of rabbit corneal epithelium from carriers to denuded corneas or cryolathed lenticules.
McCulley JP, He YG, Meyer DR, Moore MB, Li JJ Cornea 1991 Nov 10 6 466-77
The role of tetracycline in chronic blepharitis. Inhibition of lipase production in staphylococci.
Dougherty JM, McCulley JP, Silvany RE, Meyer DR Invest. Ophthalmol. Vis. Sci. 1991 Oct 32 11 2970-5
Ocular changes from electrical burn injuries. A literature review and report of cases.
Boozalis GT, Purdue GF, Hunt JL, McCulley JP J Burn Care Rehabil 1991 Sep-Oct 12 5 458-62
Growing human corneal epithelium on collagen shield and subsequent transfer to denuded cornea in vitro.
He YG, McCulley JP Curr. Eye Res. 1991 Sep 10 9 851-63
In vitro intercellular adherence of Acanthamoeba castellanii: a scanning and transmission electron microscopy study.
Ubelaker JE, Moore MB, Martin JH, Silveny R, Dougherty JM, Meyer DR, McCulley JP Cornea 1991 Jul 10 4 299-304

Honors & Awards

  • D Magazine
    Best Doctors in Dallas (2017)
  • Texas Monthly Magazine
    Super Doctors (2017)
  • Distinguished Service Award (Texas Ophthalmological Association)
    Highest honor bestowed by the TOA; a peer-recognized award acknowledging the recipient's lifelong dedication to ophthalmology patients and to the profession. (2016)
  • Life Achievement Award, American Academy of Ophthalmology
  • Washington University Medical Center
    Alumni Achievement Award (2008)
  • Harvard Medical School (formerly Massachusetts Eye and Ear Infirmary)
    Distinguished Alumni Award (2006)
  • TCU Alumni Association
    Distinguished Alumni Award (2001)
  • Castle Connolly
    America's Top Doctors (2001 onwards)

Professional Associations/Affiliations

  • Alpha Omega Alpha
  • American Academy of Ophthalmology
  • American College of Surgeons
  • American Medical Association
  • American Ophthalmological Society