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Marlyn Mayo, M.D.

Marlyn Mayo, M.D.

Professor

School
Medical School
Department
Internal Medicine

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For more information on the doctor and patient care, please visit the clinical profile.

  • Biography

    Marlyn Mayo, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Digestive and Liver Diseases. She specializes in the diagnosis and management of acute and chronic liver diseases and has a keen interest in immune-mediated and cholestatic liver diseases such as primary biliary cirrhosis, autoimmune hepatitis, and primary sclerosing cholangitis.

    Originally from Syracuse, New York, Dr. Mayo holds a bachelor's degree in psychology from Northwestern University in Evanston, Illinois. She obtained her medical degree from Baylor College of Medicine in Houston and completed internal medicine residency training at the University of California-Irvine. She then received advanced training through a fellowship program in gastroenterology and hepatology at UT Southwestern.

    Certified by the American Board of Internal Medicine in gastroenterology, Dr. Mayo joined the UT Southwestern faculty in 1996.

    Dr. Mayo came to UT Southwestern to do research and work on the largest PBC trial at the time with Burton Combes, M.D., who started the liver unit at UT Southwestern. Later, Dr. Mayo worked with Peter Lipsky, M.D., to conduct translational research on immune targets in PBC. From there, she started to investigate other autoimmune and cholestatic liver diseases. 

    Dr. Mayo's research focuses on clinical trials investigating new treatments for primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis.  She has a specific interest in cholestatic itching, and has also actively studied hepatorenal syndrome and liver diseases of pregnancy. 

    Dr. Mayo has been involved in setting the standards for medical education. She has been both the Associate Program Director and Program Director of the Gastroenterology Fellowship program at UT Southwestern. 

    Dr. Mayo is a member of several professional societies, including the American Association for the Study of Liver Diseases, the American Gastroenterological Association, the Texas Medical Association, the Dallas County Medical Society, and the American College of Gastroenterology. She has served on multiple committees for the AASLD in the areas of research and education. 

    Dr. Mayo has been included in D Magazine's Best Doctors list on numerous occasions. 

  • Education
    Medical School
    Baylor College of Medicine (1990)
    Internship
    University of California, Irvine (1991), Internal Medicine
    Residency
    University of California, Irvine (1993), Internal Medicine
    Fellowship
    UT Southwestern Medical Center (1996), Gastroenterology
  • Research Interest
    • Autoimmune liver diseases
    • Liver Disease in Pregnancy
    • Primary biliary cholangitis
    • primary sclerosing cholangitis
  • Publications

    Star Featured Publications

    Featured Featured Featured Featured Featured Featured Featured
    A Phase 3 Trial of Seladelpar in Primary Biliary Cholangitis.
    Hirschfield GM, Bowlus CL, Mayo MJ, Kremer AE, Vierling JM, Kowdley KV, Levy C, Villamil A, Ladrón de Guevara Cetina AL, Janczewska E, Zigmond E, Jeong SH, Yilmaz Y, Kallis Y, Corpechot C, Buggisch P, Invernizzi P, Londoño Hurtado MC, Bergheanu S, Yang K, Choi YJ, Crittenden DB, McWherter CA, N Engl J Med 2024 Feb 390 9 783-794
    Seladelpar treatment reduces interleukin-31 and pruritus in patients with primary biliary cholangitis.
    Kremer AE, Mayo MJ, Hirschfield GM, Levy C, Bowlus CL, Jones DE, Johnson JD, McWherter CA, Choi YJ, Hepatology 2023 Dec
    Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis.
    Kowdley KV, Bowlus CL, Levy C, Akarca US, Alvares-da-Silva MR, Andreone P, Arrese M, Corpechot C, Francque SM, Heneghan MA, Invernizzi P, Jones D, Kruger FC, Lawitz E, Mayo MJ, Shiffman ML, Swain MG, Valera JM, Vargas V, Vierling JM, Villamil A, Addy C, Dietrich J, Germain JM, Mazain S, Rafailovic D, Taddé B, Miller B, Shu J, Zein CO, Schattenberg JM, N Engl J Med 2023 Nov
  • Books

    Featured 

  • Honors & Awards
    • Education Excellence Award
      UT Southwestern Graduate Medical Education Office (2020)
    • Graduate Medical Education Excellence Award
      UT Southwestern Medical Center (2020)
    • Lyman Bihartz Teaching Award
      Fellow- Nominated Teacher of the Year (2018)
    • D Magazine Best Doctors
      Peer Nominated Award of Excellence in Clinical Care (2015-2024)
    • Independent Investigator Award
      Pfizer Pharmaceuticals (2002)
    • Liver Scholar Award
      American Liver Foundation (1996)
    • Alumni Award in Neurology
      Baylor College of Medicine (1989)
  • Professional Associations/Affiliations
    • American Association for the Study of Liver Diseases (1993)
    • American College of Gastroenterology (2014)
    • American Gastroenterological Association (1993)
    • Dallas County Medical Society (1993)
    • European Association for the Study of Liver Diseases (2013)
    • Texas Medical Association (1993)