Marlyn Mayo, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Digestive and Liver Diseases. She specializes in the diagnosis and management of acute and chronic liver diseases and has a keen interest in immune-mediated and cholestatic liver diseases such as primary biliary cirrhosis, autoimmune hepatitis, and primary sclerosing cholangitis.

Every time a patient dies from an autoimmune disease, I want to work harder to find a cure

Originally from Syracuse, New York, Dr. Mayo holds a bachelor's degree in psychology from Northwestern University in Evanston, Illinois. She obtained her medical degree from Baylor College of Medicine in Houston and completed internal medicine residency training at the University of California-Irvine. She then received advanced training through a fellowship program in gastroenterology and hepatology at UT Southwestern.

Certified by the American Board of Internal Medicine in gastroenterology, Dr. Mayo joined the UT Southwestern faculty in 1996.

Dr. Mayo came to UT Southwestern to do research and work on the largest PBC trial at the time with Burton Combs, M.D., who started the liver unit at UT Southwestern. Later, Dr. Mayo worked with Peter Lipsky, M.D., to conduct research on intrahepatic cholestasis of pregnancy (ICP). From there, she started to treat other diseases that relate to pregnancy and liver diseases. 

Dr. Mayo's research focuses on the pathogenesis of autoimmune liver diseases. The molecular events involved in bile duct damage in primary biliary cirrhosis and the development of cryoglobulins in hepatitis C are current areas of investigation. She studies how the T cell receptors and other co-stimulatory molecules on the surface of B and T lymphocytes participate in the genesis and chronic perpetuation of autoimmune diseases. Dr. Mayo also conducts clinical trials in the UT Southwestern General Clinical Research Center investigating new treatments for primary biliary cirrhosis. 

Dr. Mayo has been involved in setting the standards for medical education. She has been both the Associate Program Director and Program Director of the Gastroenterology Fellowship program at UT Southwestern.

Dr. Mayo is a member of several professional societies, including the American Association for the Study of Liver Diseases, the American Gastroenterological Association, the Texas Medical Association, the Dallas County Medical Society, and the American College of Gastroenterology.

Dr. Mayo was included in D Magazine's Best Doctors list for 2018.


Medical School
Baylor College of Medicine (1990)
University of California, Irvine (1991), Internal Medicine
University of California, Irvine (1993), Internal Medicine
UT Southwestern Medical Center (1996), Gastroenterology

Research Interest

  • Autoimmune liver diseases
  • Liver Disease in Pregnancy
  • Primary biliary cholangitis
  • primary sclerosing cholangitis


Featured Publications LegendFeatured Publications

Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the study of liver diseases.
Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ, Hepatology 2019 Dec
A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis.
Mayo MJ, Pockros PJ, Jones D, Bowlus CL, Levy C, Patanwala I, Bacon B, Luketic V, Vuppalanchi R, Medendorp S, Dorenbaum A, Kennedy C, Novak P, Gu J, Apostol G, Hirschfield GM, Hepatol Commun 2019 Mar 3 3 365-381
Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases.
Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M, Hepatology 2019 01 69 1 394-419


Featured Books Legend Featured Books

Honors & Awards

  • Education Excellence Award
    UT Southwestern Graduate Medical Education Office (2020)
  • Graduate Medical Education Excellence Award
    UT Southwestern Medical Center (2020)
  • Lyman Bihartz Teaching Award
    Fellow- Nominated Teacher of the Year (2018)
  • D Magazine Best Doctors
    Peer Nominated Award of Excellence in Clinical Care (2015-2019)
  • Independent Investigator Award
    Pfizer Pharmaceuticals (2002)
  • Liver Scholar Award
    American Liver Foundation (1996)
  • Alumni Award in Neurology
    Baylor College of Medicine (1989)

Professional Associations/Affiliations

  • American Association for the Study of Liver Diseases (1993)
  • American College of Gastroenterology (2014)
  • American Gastroenterological Association (1993)
  • Dallas County Medical Society (1993)
  • European Association for the Study of Liver Diseases (2013)
  • Texas Medical Association (1993)