Marlyn Mayo, M.D.

Marlyn Mayo, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Digestive and Liver Diseases. She specializes in the diagnosis and management of acute and chronic liver diseases and has a keen interest in immune-mediated and cholestatic liver diseases such as primary biliary cirrhosis, autoimmune hepatitis, and primary sclerosing cholangitis.

Every time a patient dies from an autoimmune disease, I want to work harder to find a cure

Originally from Syracuse, New York, Dr. Mayo holds a bachelor's degree in psychology from Northwestern University in Evanston, Illinois. She obtained her medical degree from Baylor College of Medicine in Houston and completed internal medicine residency training at the University of California-Irvine. She then received advanced training through a fellowship program in gastroenterology and hepatology at UT Southwestern.

Certified by the American Board of Internal Medicine in gastroenterology, Dr. Mayo joined the UT Southwestern faculty in 1996.

Dr. Mayo came to UT Southwestern to do research and work on the largest PBC trial at the time with Burton Combs, M.D., who started the liver unit at UT Southwestern. Later, Dr. Mayo worked with Peter Lipsky, M.D., to conduct research on intrahepatic cholestasis of pregnancy (ICP). From there, she started to treat other diseases that relate to pregnancy and liver diseases. 

Dr. Mayo's research focuses on the pathogenesis of autoimmune liver diseases. The molecular events involved in bile duct damage in primary biliary cirrhosis and the development of cryoglobulins in hepatitis C are current areas of investigation. She studies how the T cell receptors and other co-stimulatory molecules on the surface of B and T lymphocytes participate in the genesis and chronic perpetuation of autoimmune diseases. Dr. Mayo also conducts clinical trials in the UT Southwestern General Clinical Research Center investigating new treatments for primary biliary cirrhosis. 

Dr. Mayo has been involved in setting the standards for medical education. She has been both the Associate Program Director and Program Director of the Gastroenterology Fellowship program at UT Southwestern.

Dr. Mayo is a member of several professional societies, including the American Association for the Study of Liver Diseases, the American Gastroenterological Association, the Texas Medical Association, the Dallas County Medical Society, and the American College of Gastroenterology.

Dr. Mayo was included in D Magazine's Best Doctors list for 2018.

Medical School

Baylor College of Medicine (1990)

Internship

University of California, Irvine (1991), Internal Medicine

Residency

University of California, Irvine (1993), Internal Medicine

Fellowship

UT Southwestern Medical Center (1996), Gastroenterology

• Autoimmune liver diseases
• Liver Disease in Pregnancy
• Primary biliary cholangitis
• primary sclerosing cholangitis

Featured Publications

Updated Etiology and Significance of Elevated Bilirubin During Pregnancy: Changes Parallel Shift in Demographics and Vaccination Status.

Duraiswamy S, Sheffield JS, Mcintire D, Leveno K, Mayo MJ Dig. Dis. Sci. 2016 Sep

Predicting Outcomes of Primary Biliary Cholangitis Using the GLOBE Score.

Mayo MJ Gastroenterol Hepatol (N Y) 2015 Dec 11 12 842-4

Development of a Successful Scholarly Activity and Research Program for Subspecialty Trainees.

Mayo MJ, Rockey DC Am. J. Med. Sci. 2015 May

American Association for the Study of Liver Diseases endpoints conference: design and endpoints for clinical trials in primary biliary cirrhosis.

Silveira MG, Brunt EM, Heathcote J, Gores GJ, Lindor KD, Mayo MJ Hepatology 2010 Jul 52 1 349-59

The 5-D itch scale: a new measure of pruritus.

Elman S, Hynan LS, Gabriel V, Mayo MJ Br. J. Dermatol. 2010 Mar 162 3 587-93

Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay.

Mayo MJ, Parkes J, Adams-Huet B, Combes B, Mills AS, Markin RS, Rubin R, Wheeler D, Contos M, West AB, Saldana S, Getachew Y, Butsch R, Luketic V, Peters M, Di Bisceglie A, Bass N, Lake J, Boyer T, Martinez E, Boyer J, Garcia-Tsao G, Barnes D, Rosenberg WM Hepatology 2008 Nov 48 5 1549-57

Sertraline as a first-line treatment for cholestatic pruritus.

Mayo MJ, Handem I, Saldana S, Jacobe H, Getachew Y, Rush AJ Hepatology 2007 Mar 45 3 666-74

Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the study of liver diseases.

Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ, Hepatology 2019 Dec

A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis.

Mayo MJ, Pockros PJ, Jones D, Bowlus CL, Levy C, Patanwala I, Bacon B, Luketic V, Vuppalanchi R, Medendorp S, Dorenbaum A, Kennedy C, Novak P, Gu J, Apostol G, Hirschfield GM, Hepatol Commun 2019 Mar 3 3 365-381

Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases.

Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M, Hepatology 2019 01 69 1 394-419

 Featured Books

Primary Biliary Cirrhosis. In Yamada's Atlas of Gastroenterology, 7th edition

Mayo MJ, (2020). Wily Blackwell

Primary Biliary Cirrhosis. In Yamada's Textbook of Gastroenterology, 7th edition

Mayo MJ (2020). Wily Blackwell

Complications of Cholestasis. In Cholestatic Liver Disease 2nd edition

Ahmed A and Mayo MJ (2014). Humana Press

Budd-Chiari Syndrome, Portal Vein Thrombosis and Other Vascular Disorders of the Liver.. In Handbook of Liver Diseases

Mayo MJ and Mitchell MC (2016).

• Education Excellence Award
  UT Southwestern Graduate Medical Education Office (2020)
• Graduate Medical Education Excellence Award
  UT Southwestern Medical Center (2020)
• Lyman Bihartz Teaching Award
  Fellow- Nominated Teacher of the Year (2018)
• D Magazine Best Doctors
  Peer Nominated Award of Excellence in Clinical Care (2015-2019)
• Independent Investigator Award
  Pfizer Pharmaceuticals (2002)
• Liver Scholar Award
  American Liver Foundation (1996)
• Alumni Award in Neurology
  Baylor College of Medicine (1989)

• American Association for the Study of Liver Diseases (1993)
• American College of Gastroenterology (2014)
• American Gastroenterological Association (1993)
• Dallas County Medical Society (1993)
• European Association for the Study of Liver Diseases (2013)
• Texas Medical Association (1993)