Darin T. Okuda, M.D., is a Professor in the Department of Neurology at UT Southwestern Medical Center. He is a clinician-scientist specializing in multiple sclerosis and other demyelinating disorders of the central nervous system. 

Dr. Okuda serves as Director of the Neuroinnovation Program and Multiple Sclerosis and Neuroimmunology Imaging Program.

Born and raised in Hawaii, Dr. Okuda earned his undergraduate, graduate, and medical degrees at the University of Hawaii. He completed his residency training in neurology at the Barrow Neurological Institute and performed his fellowship in neuroimmunology at the University of California-San Francisco Multiple Sclerosis Center.

Dr. Okuda’s is nationally and internationally recognized for his recent work in defining and investigating the radiologically isolated syndrome. His current research focuses on creating next generation healthcare by designing innovative connections between patients and providers, developing new diagnostic and clinical surveillance metrics, and transforming medical decision-making. He is actively involved in end-to-end dynamic approaches for the design, creation, and implementation of extreme healthcare concepts aimed at delivering care more accurately, efficiently, and intelligently.

Dr. Okuda is a Diplomate of the American Board of Psychiatry and Neurology Inc., a Fellow of the American Academy of Neurology, a Fellow of the American Neurological Association, and a member of the American Academy of Neurology Committees on Neuroimaging and Ethics.

Dr. Okuda’s work has been published in the Annals of Neurology, Neurology, Human Molecular GeneticsBrainJournal of NeuroImagingProceedings of the National American Academy of Sciences, and Science.


Medical School
University of Hawaii at Manoa John A. Burns School of Medicine (2000)
St. Joseph's Hospital & Medical Center (2001), Internal Medicine
St. Joseph's Hospital & Med. Ctr. (2004), Neurology
UCSF Multiple Sclerosis Center (2006), Neuroimmunology

Research Interest

  • 3-Dimensional conformational metrics
  • Artificial intelligence
  • Multiple sclerosis
  • Myelin oligodendrocyte glycoprotein antibody-associated disease
  • Neuroimaging
  • Neuromyelitis optica spectrum disorder
  • Radiologically isolated syndrome
  • Software development


The diagnostic value of the central vein sign in radiologically isolated syndrome
Landes-Chateau C, Levraut M, Okuda DT, Themelin A, Cohen M, Kantarci OH, Siva A, Pelletier D, Mondot L, Lebrun-Frenay C Annals of Clinical and Translational Neurology 2024 Mar 11 662-672
Reduced resting beat-to-beat blood pressure variability in females with relapsing-remitting multiple sclerosis
Kissell CE, Young BE, Jarrard CP, Huang M, Allen DR, Okuda DT, Smith SA, Fadel PJ, Davis SL Multiple Sclerosis and Related Disorders 2024 Mar 83
Time to move past typical syndromes in the diagnosis of multiple sclerosis
Lebrun-Frenay C, Okuda DT Multiple Sclerosis Journal 2024
Investigating the link between regional oxygen metabolism and cognitive speed in multiple sclerosis: Implications for fatigue
Zuppichini MD, Sivakolundu DK, West KL, Okuda DT, Rypma B Multiple Sclerosis and Related Disorders 2023 Dec 80
Reply: Do we need new MRI criteria for the diagnosis of radiologically isolated syndrome?
Lebrun-Frenay C, Kantarci OH, Siva A, Pelletier D, Okuda DT Brain 2023 Nov 146 E104-E106
Treatment transitions in neuromyelitis optica spectrum disorder increase risk for disease advancement
Okuda DT, Moog TM, McCreary M, Cook K, Burgess KW, Smith AD Multiple Sclerosis and Related Disorders 2023 Nov 79
Radiologically isolated syndrome
Lebrun-Frenay C, Kantarci O, Siva A, Azevedo CJ, Makhani N, Pelletier D, Okuda DT The Lancet Neurology 2023 Nov 22 1075-1086
Teriflunomide and Time to Clinical Multiple Sclerosis in Patients with Radiologically Isolated Syndrome: The TERIS Randomized Clinical Trial
Lebrun-Frénay C, Siva A, Sormani MP, Landes-Chateau C, Mondot L, Bovis F, Vermersch P, Papeix C, Thouvenot E, Labauge P, Durand-Dubief F, Efendi H, Le Page E, Terzi M, Derache N, Bourre B, Hoepner R, Karabudak R, De Seze J, Ciron J, Clavelou P, Wiertlewski S, Turan OF, Yucear N, Cohen M, Azevedo C, Kantarci OH, Okuda DT, Pelletier D JAMA neurology 2023 Oct 80 1080-1088
Real-World Safety and Effectiveness After 5 Years of Dimethyl Fumarate Treatment in Black and Hispanic Patients with Multiple Sclerosis in ESTEEM
Williams MJ, Amezcua L, Chinea A, Cohan S, Okai A, Okuda DT, Vargas W, Belviso N, Božin I, Jiang X, Lewin JB, Lyons J, Shen C, England SM, Grimes N Neurology and Therapy 2023 Oct 12 1669-1682
MRI to differentiate multiple sclerosis, neuromyelitis optica, and myelin oligodendrocyte glycoprotein antibody disease
Carnero Contentti E, Okuda DT, Rojas JI, Chien C, Paul F, Alonso R Journal of Neuroimaging 2023 Sep 33 688-702


Featured Books Legend Featured Books

Primary Angiitis of the Central Nervous System. In MR Imaging in White Matter Disease of the Brain and Spinal Cord

Okuda DT, Vollmer TL (2006).

Enough of the Fear: An Insider's Guide to Understanding, Managing, and Living Well with Multiple Sclerosis

Wright, K, Winkler M, Okuda DT (2019).

Radiologically Isolated Syndrome: MR Imaging Features Suggestive of Multiple Sclerosis Prior to First Symptom Onset. In Advances in Imaging of Multiple Sclerosis

Okuda, DT (2017).

Immunosuppressive Treatments in Multiple Sclerosis. In Handbook of Clinical Neurology, Multiple Sclerosis and Related Disorders

Okuda, DT (2014).

Honors & Awards

  • Mimics Innovation Award 2020
    North and South America Finalist (2020)
  • STRATASYS Neuroscience Innovation Award
    Advancing neuroscience through the study of changes in 3-dimensional conformation (2020)
  • Alpha Omega Alpha Honor Medical Society
  • American Academy of Neurology, Brainstorm: A Competition for the Innovator in All of Us, Grand Prize Winner
    Innovation Award (2018)
  • International Congress on Advanced Treatments & Technologies in Multiple Sclerosis
    Best Abstract Award (2018)
  • Merck KGaA: Multiple Sclerosis Innovation Award
    Award for 3-dimensional modeling in multiple sclerosis (2018)
  • Reality Science: DeeperMind Innovation Award
    Innovative approach towards understanding MS through augmented reality (2018)
  • Alpha Omega Alpha Honor Medical Society Research Fellowship
    Research fellow within the field of vascular surgery (1997)

Professional Associations/Affiliations

  • American Society of Neuroimaging (2008)
  • Fellow, American Academy of Neurology (2014)
  • Fellow, American Neurological Association (2014)
  • Fellow, British Medical Journal (2009)
  • New York Academy of Sciences (2016)