Carlos L. Arteaga, M.D., a devoted cancer researcher and clinician, was named Director of the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center in September 2017. He also serves as Associate Dean of Oncology Programs. Dr. Arteaga is internationally recognized for his work in laboratory-based translational research and advancing the care of breast cancer patients. The majority of Dr. Arteaga’s career has been as a physician-scientist in Medical Oncology at the Vanderbilt-Ingram Cancer Center of Vanderbilt University, where he served as Associate Director for Translational/Clinical Research and Director of the Center for Cancer Targeted Therapies. At Vanderbilt, he also led a successful translational research program that includes a National Cancer Institute/National Institutes of Health SPORE award in breast cancer. He is a member of the American Society for Clinical Investigation and the Association of American Physicians. He has earned numerous accolades from the American Cancer Society, the American Association for Cancer Research (AACR), Susan G. Komen for the Cure Foundation, and the American Society of Clinical Oncology. A former President of the AACR, he serves on the boards of advisors of several cancer centers and breast cancer programs. Dr. Arteaga earned his medical degree from Facultad de Ciencias Médicas at the Universidad de Guayaquil in Ecuador. He trained in Internal Medicine at Emory University and in Medical Oncology at the University of Texas Health Science Center at San Antonio.
- Medical School
- Universidad de Guayaquil, Ecuador (1980)
- Emory University School of Medicine (1984), Internal Medicine
- University of Texas Health Science Center, San Antonio (1988), Hematology Oncology
- Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer.
- Dennison JB, Molina JR, Mitra S, González-Angulo AM, Balko JM, Kuba MG, Sanders ME, Pinto JA, Gómez HL, Arteaga CL, Brown RE, Mills GB Clin. Cancer Res. 2013 Jul 19 13 3703-13
- Phosphatase and tensin homolog deficiency and resistance to trastuzumab and chemotherapy.
- Rexer BN, Shyr Y, Arteaga CL J. Clin. Oncol. 2013 Jun 31 17 2073-5
- TGF-ß inhibition enhances chemotherapy action against triple-negative breast cancer.
- Bhola NE, Balko JM, Dugger TC, Kuba MG, Sánchez V, Sanders M, Stanford J, Cook RS, Arteaga CL J. Clin. Invest. 2013 Mar 123 3 1348-58
- Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors.
- Chakrabarty A, Bhola NE, Sutton C, Ghosh R, Kuba MG, Dave B, Chang JC, Arteaga CL Cancer Res. 2013 Feb 73 3 1190-200
- Dual blockade of HER2 in HER2-overexpressing tumor cells does not completely eliminate HER3 function.
- Garrett JT, Sutton CR, Kuba MG, Cook RS, Arteaga CL Clin. Cancer Res. 2013 Feb 19 3 610-9
- The genomic map of breast cancer: which roads lead to better targeted therapies?
- Balko JM, Stricker TP, Arteaga CL Breast Cancer Res. 2013 15 4 209
- Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation.
- Fox EM, Kuba MG, Miller TW, Davies BR, Arteaga CL Breast Cancer Res. 2013 15 4 R55
- Biomarkers of response to Akt inhibitor MK-2206 in breast cancer.
- Sangai T, Akcakanat A, Chen H, Tarco E, Wu Y, Do KA, Miller TW, Arteaga CL, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F Clin. Cancer Res. 2012 Oct 18 20 5816-28
- Discordant cellular response to presurgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification.
- Balko JM, Mayer IA, Sanders ME, Miller TW, Kuba MG, Meszoely IM, Wagle N, Garraway LA, Arteaga CL Mol. Cancer Ther. 2012 Oct 11 10 2301-5
- Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance.
- Balko JM, Cook RS, Vaught DB, Kuba MG, Miller TW, Bhola NE, Sanders ME, Granja-Ingram NM, Smith JJ, Meszoely IM, Salter J, Dowsett M, Stemke-Hale K, González-Angulo AM, Mills GB, Pinto JA, Gómez HL, Arteaga CL Nat. Med. 2012 Jul 18 7 1052-9