Download Curriculum Vitae

Dr. Mason is Director of the Cancer Imaging Program at UT Southwestern with over 20 year's experience in cancer imaging, therapy, and tumor pathophysiology. He is Professor of Radiology and member of the Simmons Comprehensive Cancer Center. He serves on faculty of graduate programs in Biomedical Engineering, Molecular Biophysics and Cancer Biology. Dr. Mason and his research team have been supported for many years by NCI, DOD breast and prostate cancer initiatives, various foundations including The American Cancer Society, The Whitaker Foundation, and The Mary Kay Ash Foundation and most recently CPRIT. Dr. Mason’s primary research interest is prognostic radiology- developing and implementing methods for predicting optimal cancer therapy and assessing early response to treatment. Current investigations focus on development of oxygen sensitive MRI in pre-clinical breast, prostate and lung cancer as well as translation to human lung and prostate cancer. Dr. Mason is a recognized expert in the development of novel MR and optical reporter starategies with notable innovations in 19F NMR. Recent pre-clinical innovations include dynamic bioluminescent imaging related to vascular disputing agents and in vivo chemiluminescent imaging. Ongoing projects focus on novel vascular disrupting agents  and assessment of pathophysiology of tumor response to therapy.


University of Cambridge (1983), Natural Sciences
Graduate School
University of Cambridge (1986), Organic Chemistry

Research Interest

  • Application of imaging methods to tumor development and response to therapy; development of NMR reporter molecules as probes of physiology and gene transfection; detoxification of xenobiotica; MR miscroscopy and tissue microstructure.
  • Bioluminescent imaging
  • gene therapy
  • NMR- MRI
  • Oxygen


Featured Publications LegendFeatured Publications

Assessment of tumor response to oxygen challenge using quantitative diffusion MRI in an animal model.
Zhang Z, Yuan Q, Zhou H, Zhao D, Li L, Gerberich JL, Mason RP J Magn Reson Imaging 2015 Apr
Chemiluminescent Probes for Imaging H2S in Living Animals.
Cao J, Lopez R, Thacker JM, Moon JY, Jiang C, Morris SN, Bauer JH, Tao P, Mason RP, Lippert AR Chem Sci 2015 Mar 6 3 1979-1985
Convertible MRI contrast: Sensing the delivery and release of anti-glioma nano-drugs.
Zhang L, Zhang Z, Mason RP, Sarkaria JN, Zhao D Sci Rep 2015 5 9874
Dynamic bioluminescence and fluorescence imaging of the effects of the antivascular agent Combretastatin-A4P (CA4P) on brain tumor xenografts.
Liu L, Mason RP, Gimi B Cancer Lett. 2014 Oct
Red-shifted emission from 1,2-dioxetane-based chemiluminescent reactions.
Park JY, Gunpat J, Liu L, Edwards B, Christie A, Xie XJ, Kricka LJ, Mason RP Luminescence 2014 Sep 29 6 ii
Dynamic contrast enhanced fluorescent molecular imaging of vascular disruption induced by combretastatin-A4P in tumor xenografts.
Liu L, Su X, Mason RP J Biomed Nanotechnol 2014 Aug 10 8 1545-51
Use of Fc-Engineered Antibodies as Clearing Agents to Increase Contrast During PET.
Swiercz R, Chiguru S, Tahmasbi A, Ramezani SM, Hao G, Challa DK, Lewis MA, Kulkarni PV, Sun X, Ober RJ, Mason RP, Ward ES J. Nucl. Med. 2014 May
Phosphatidylserine-targeted molecular imaging of tumor vasculature by magnetic resonance imaging.
Zhou H, Stafford JH, Hallac RR, Zhang L, Huang G, Mason RP, Gao J, Thorpe PE, Zhao D J Biomed Nanotechnol 2014 May 10 5 846-55
Red-shifted emission from 1,2-dioxetane-based chemiluminescent reactions.
Park JY, Gunpat J, Liu L, Edwards B, Christie A, Xie XJ, Kricka LJ, Mason RP Luminescence 2014 Apr
Development of Intrinsically Photoluminescent and Photostable Polylactones.
Xie Z, Zhang Y, Liu L, Weng H, Mason RP, Tang L, Nguyen KT, Hsieh JT, Yang J Adv. Mater. Weinheim 2014 Mar


Featured Books Legend Featured Books

Non-Invasive Physiology and Pharmacology Using 19F Magnetic Resonance. In FLOURINE AND HEALTH

J.X. Yu, W. Cui, D. Zhao, and R. P. Mason (May 2008). Elsevier B.V.

Fluorocarbon Agents for Quantitative Multimodal Molecular Imaging and Targeted Therapeutics. In Molecular Imaging: Principles and Practice

S. A. Wickline, R. P. Mason, S. D. Caruthers, J. Chen, P. M. Winter, M. S. Hughes, G. M. Lanza (2010). People?s Medical Publishing House

MRI Hypoxia Measurements. In Functional Imaging in Oncology

S. Remmele, R. P. Mason, and J. P.B. O?Connor (2014). Heidelberg, Springer-Verlag

Innovative applications of reporter genes and gene reporters in prostate cancer. In Prostate Cancer Cells: Detection, Growth and Treatment

L. Liu, M. K. Alhasan, W. Cui, J. Magnusson, and R. P. Mason (2013). Hauppauge, NY, Nova Science Publishers

Honors & Awards

  • Outstanding Teacher Award: International Society for Magnetic Resonance in Medicine (ISMRM), Honolulu, HI
    “Beyond Proton MRI: 19F MRI & More” (2017)
  • Outstanding Teacher Award: International Society for Magnetic Resonance in Medicine (ISMRM), Singapore
  • Visiting Professor to the Hubei University of Medicine (HUM)
    Famous Scientists Lecture Program in Hubei Province (2015-2015)
  • Fellow of Royal Society of Chemistry
    FRSC (2012)
  • CSci
    Chartered Scientist designation of the Science Council (2004)
  • Lyndon Baines Johnson Award
    American Heart Association (Texas Affiliate) (1993)
  • Young Investigator Award at 5th International Society of Blood Substitutes Meeting
    Presentation: “Tumor oxygen tension: Measurement using OxygentTM as a 19F NMR probe at 4.7 T (1993)
  • CChem
    Chartered Chemist of the Royal Society of Chemistry (1987)

Professional Associations/Affiliations

  • American Journal of Nuclear Medicine and Molecular Imaging (2011)
  • Imaging in Medicine (2009)
  • Letters in Drug Design & Discovery (2005)
  • American Association for Cancer Research (1993)
  • International Society of Magnetic Resonance in Medicine (1990)
  • Royal Society of Chemistry (1987)