Biography

Download Curriculum Vitae

Dr. Mason is Director of the Cancer Imaging Program at UT Southwestern with over 20 year's experience in cancer imaging, therapy, and tumor pathophysiology. He is Professor of Radiology and member of the Simmons Comprehensive Cancer Center. He serves on faculty of graduate programs in Biomedical Engineering, Molecular Biophysics and Cancer Biology. Dr. Mason and his research team have been supported for many years by NCI, DOD breast and prostate cancer initiatives, various foundations including The American Cancer Society, The Whitaker Foundation, and The Mary Kay Ash Foundation and most recently CPRIT. Dr. Mason’s primary research interest is prognostic radiology- developing and implementing methods for predicting optimal cancer therapy and assessing early response to treatment. Current investigations focus on development of oxygen sensitive MRI in pre-clinical breast, prostate and lung cancer as well as translation to human lung and prostate cancer. Dr. Mason is a recognized expert in the development of novel MR and optical reporter starategies with notable innovations in 19F NMR. Recent pre-clinical innovations include dynamic bioluminescent imaging related to vascular disputing agents and in vivo chemiluminescent imaging. Ongoing projects focus on novel vascular disrupting agents  and assessment of pathophysiology of tumor response to therapy.

Education

Undergraduate
University of Cambridge (1983), Natural Sciences
Graduate School
University of Cambridge (1986), Organic Chemistry

Research Interest

  • Application of imaging methods to tumor development and response to therapy; development of NMR reporter molecules as probes of physiology and gene transfection; detoxification of xenobiotica; MR miscroscopy and tissue microstructure.
  • Bioluminescent imaging
  • gene therapy
  • NMR- MRI
  • Oxygen

Publications

Featured Publications LegendFeatured Publications

In Vivo Chemiluminescent Imaging Agents for Nitroreductase and Tissue Oxygenation.
Cao J, Campbell J, Liu L, Mason RP, Lippert AR Anal. Chem. 2016 Apr
Inorganic phosphate-triggered release of anti-cancer arsenic trioxide from a self-delivery system: an in vitro and in vivo study.
Chen FY, Yi JW, Gu ZJ, Tang BB, Li JQ, Li L, Kulkarni P, Liu L, Mason RP, Tang Q Nanoscale 2016 Mar 8 11 6094-100
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
Devkota L, Lin CM, Strecker TE, Wang Y, Tidmore JK, Chen Z, Guddneppanavar R, Jelinek CJ, Lopez R, Liu L, Hamel E, Mason RP, Chaplin DJ, Trawick ML, Pinney KG Bioorg. Med. Chem. 2016 Mar 24 5 938-56
Tumor radio-sensitivity assessment by means of volume data and magnetic resonance indices measured on prostate tumor bearing rats.
Belfatto A, White DA, Mason RP, Zhang Z, Stojadinovic S, Baroni G, Cerveri P Med Phys 2016 Mar 43 3 1275
Assessment of tumor response to oxygen challenge using quantitative diffusion MRI in an animal model.
Zhang Z, Yuan Q, Zhou H, Zhao D, Li L, Gerberich JL, Mason RP J Magn Reson Imaging 2015 Nov 42 5 spcone
Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization.
Herdman CA, Devkota L, Lin CM, Niu H, Strecker TE, Lopez R, Liu L, George CS, Tanpure RP, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG Bioorg. Med. Chem. 2015 Oct
Commentary on Photoacoustic Tomography.
Mason RP J. Nucl. Med. 2015 Sep
The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.
Strecker TE, Odutola SO, Lopez R, Cooper MS, Tidmore JK, Charlton-Sevcik AK, Li L, MacDonough MT, Hadimani MB, Ghatak A, Liu L, Chaplin DJ, Mason RP, Pinney KG, Trawick ML Cancer Lett. 2015 Sep
Mathematical modeling of tumor response to radiation: radio-sensitivity correlation with BOLD, TOLD, ?R1 and ?R2* investigated in large Dunning R3327-AT1 rat prostate tumors.
Belfatto A, White DA, Zhongwei ZhangZhang ZhangCerveri P, Baroni G, Mason RP Conf Proc IEEE Eng Med Biol Soc 2015 Aug 2015 3266-9
TH-CD-204-05: Developing a Non-Invasive MRI Prognostic Biomarker to Predict Response to Hypofractionated Radiotherapy.
White DA, Zhang Z, Li L, Gerberich J, Zhou H, Zhang Z, Saha D, Peschke P, Mason RP Med Phys 2015 Jun 42 6 3732

Books

Featured Books Legend Featured Books

Non-Invasive Physiology and Pharmacology Using 19F Magnetic Resonance. In FLOURINE AND HEALTH

J.X. Yu, W. Cui, D. Zhao, and R. P. Mason (May 2008). Elsevier B.V.

Fluorocarbon Agents for Quantitative Multimodal Molecular Imaging and Targeted Therapeutics. In Molecular Imaging: Principles and Practice

S. A. Wickline, R. P. Mason, S. D. Caruthers, J. Chen, P. M. Winter, M. S. Hughes, G. M. Lanza (2010). People?s Medical Publishing House

MRI Hypoxia Measurements. In Functional Imaging in Oncology

S. Remmele, R. P. Mason, and J. P.B. O?Connor (2014). Heidelberg, Springer-Verlag

Innovative applications of reporter genes and gene reporters in prostate cancer. In Prostate Cancer Cells: Detection, Growth and Treatment

L. Liu, M. K. Alhasan, W. Cui, J. Magnusson, and R. P. Mason (2013). Hauppauge, NY, Nova Science Publishers

Honors & Awards

  • Outstanding Teacher Award: International Society for Magnetic Resonance in Medicine (ISMRM), Honolulu, HI
    “Beyond Proton MRI: 19F MRI & More” (2017)
  • Outstanding Teacher Award: International Society for Magnetic Resonance in Medicine (ISMRM), Singapore
    (2016)
  • Visiting Professor to the Hubei University of Medicine (HUM)
    Famous Scientists Lecture Program in Hubei Province (2015-2015)
  • Fellow of Royal Society of Chemistry
    FRSC (2012)
  • CSci
    Chartered Scientist designation of the Science Council (2004)
  • Lyndon Baines Johnson Award
    American Heart Association (Texas Affiliate) (1993)
  • Young Investigator Award at 5th International Society of Blood Substitutes Meeting
    Presentation: “Tumor oxygen tension: Measurement using OxygentTM as a 19F NMR probe at 4.7 T (1993)
  • CChem
    Chartered Chemist of the Royal Society of Chemistry (1987)

Professional Associations/Affiliations

  • American Journal of Nuclear Medicine and Molecular Imaging (2011)
  • Imaging in Medicine (2009)
  • Letters in Drug Design & Discovery (2005)
  • American Association for Cancer Research (1993)
  • International Society of Magnetic Resonance in Medicine (1990)
  • Royal Society of Chemistry (1987)