Sebastian Winter, Ph.D.
Assistant Professor

Graduate School

(2010), Biology

• Dysbiosis of the Gut Microbiota
• Gut Microbiota Imbalance and Colorectal Cancer
• Host-Microbe Interactions During Episodes of Inflammation
• Metabolism and Virulence During Salmonella Infection
• Pathogenesis of Non-typhoidal Salmonella Infections

Featured Publications

Precision editing of the gut microbiota ameliorates colitis.

Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE Nature 2018 Jan 553 7687 208-211

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.

Gillis CC, Hughes ER, Spiga L, Winter MG, Zhu W, Furtado de Carvalho T, Chanin RB, Behrendt CL, Hooper LV, Santos RL, Winter SE Cell Host Microbe 2017 Dec

An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate.

Spiga L, Winter MG, Furtado de Carvalho T, Zhu W, Hughes ER, Gillis CC, Behrendt CL, Kim J, Chessa D, Andrews-Polymenis HL, Beiting DP, Santos RL, Hooper LV, Winter SE Cell Host Microbe 2017 Aug

Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis.

Hughes ER, Winter MG, Duerkop BA, Spiga L, Furtado de Carvalho T, Zhu W, Gillis CC, Büttner L, Smoot MP, Behrendt CL, Cherry S, Santos RL, Hooper LV, Winter SE Cell Host Microbe 2017 Feb 21 2 208-219

Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production.

Wang S, El-Fahmawi A, Christian DA, Fang Q, Radaelli E, Chen L, Sullivan MC, Misic AM, Ellringer JA, Zhu XQ, Winter SE, Hunter CA, Beiting DP, MBio 2019 May 10 3

STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium.

Wilson RP, Tursi SA, Rapsinski GJ, Medeiros NJ, Le LS, Kotredes KP, Patel S, Liverani E, Sun S, Zhu W, Kilpatrick L, Winter SE, Gamero AM, Tükel Ç, PLoS Pathog. 2019 Apr 15 4 e1007745

Transition metals and host-microbe interactions in the inflamed intestine.

Zhu W, Spiga L, Winter S, Biometals 2019 Feb

genes involved in l-lactate utilization during gut colonization.

Gillis CC, Winter MG, Chanin RB, Zhu W, Spiga L, Winter SE Infect. Immun. 2019 Jan

Using Enteric Pathogens to Probe the Gut Microbiota.

Spiga L, Winter SE Trends Microbiol. 2018 Dec

Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation.

Miyata N, Morris LL, Chen Q, Thorne C, Singla A, Zhu W, Winter M, Melton SD, Li H, Sifuentes-Dominguez L, Llano E, Huff-Hardy K, Starokadomskyy P, Lopez A, Reese TA, Turer E, Billadeau DD, Winter SE, Burstein E Cell Rep 2018 Aug 24 9 2342-2355

• BWF Investigator in the Pathogenesis of Infectious Disease
  Burroughs Wellcome Fund (2018)
• Research Scholar
  American Cancer Society (2017)
• ICAAC Young Investigator Award
  American Society for Microbiology (2014)
• Becton Dickinson Research Award
  Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology) (2011)

• Editorial Board, Clinical and Vaccine Immunology (2015-2017)
• Editorial Board, Infection and Immunity (2012)
• Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology) (2011)
• American Society for Microbiology (2006)