Sebastian Winter, Ph.D.
Assistant Professor

Graduate School

(2010), Biology

• Dysbiosis of the Gut Microbiota
• Gut Microbiota Imbalance and Colorectal Cancer
• Host-Microbe Interactions During Episodes of Inflammation
• Metabolism and Virulence During Salmonella Infection
• Pathogenesis of Non-typhoidal Salmonella Infections

Featured Publications

Precision editing of the gut microbiota ameliorates colitis.

Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE Nature 2018 Jan 553 7687 208-211

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.

Gillis CC, Hughes ER, Spiga L, Winter MG, Zhu W, Furtado de Carvalho T, Chanin RB, Behrendt CL, Hooper LV, Santos RL, Winter SE Cell Host Microbe 2017 Dec

An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate.

Spiga L, Winter MG, Furtado de Carvalho T, Zhu W, Hughes ER, Gillis CC, Behrendt CL, Kim J, Chessa D, Andrews-Polymenis HL, Beiting DP, Santos RL, Hooper LV, Winter SE Cell Host Microbe 2017 Aug

Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis.

Hughes ER, Winter MG, Duerkop BA, Spiga L, Furtado de Carvalho T, Zhu W, Gillis CC, Büttner L, Smoot MP, Behrendt CL, Cherry S, Santos RL, Hooper LV, Winter SE Cell Host Microbe 2017 Feb 21 2 208-219

Utilization of host polyamines in alternatively activated macrophages promotes chronic infection by Brucella abortus.

Kerrinnes T, Winter MG, Young BM, Diaz-Ochoa VE, Winter SE, Tsolis RM Infect. Immun. 2017 Dec

Bacteria Facilitate Enteric Virus Co-infection of Mammalian Cells and Promote Genetic Recombination.

Erickson AK, Jesudhasan PR, Mayer MJ, Narbad A, Winter SE, Pfeiffer JK Cell Host Microbe 2017 Dec

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine.

Bel S, Pendse M, Wang Y, Li Y, Ruhn KA, Hassell B, Leal T, Winter SE, Xavier RJ, Hooper LV Science 2017 Jul

Microbiota-Derived Short-Chain Fatty Acids Modulate Expression of Campylobacter jejuni Determinants Required for Commensalism and Virulence.

Luethy PM, Huynh S, Ribardo DA, Winter SE, Parker CT, Hendrixson DR MBio 2017 May 8 3

Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis.

Faber F, Thiennimitr P, Spiga L, Byndloss MX, Litvak Y, Lawhon S, Andrews-Polymenis HL, Winter SE, Bäumler AJ PLoS Pathog. 2017 Jan 13 1 e1006129

Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium.

Costa LF, Mol JP, Silva AP, Macêdo AA, Silva TM, Alves GE, Winter S, Winter MG, Velazquez EM, Byndloss MX, Bäumler AJ, Tsolis RM, Paixão TA, Santos RL Int. J. Med. Microbiol. 2016 Dec 306 8 604-610

• BWF Investigator in the Pathogenesis of Infectious Disease
  Burroughs Wellcome Fund (2018)
• Research Scholar
  American Cancer Society (2017)
• ICAAC Young Investigator Award
  American Society for Microbiology (2014)
• Becton Dickinson Research Award
  Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology) (2011)

• Editorial Board, Clinical and Vaccine Immunology (2015-2017)
• Editorial Board, Infection and Immunity (2012)
• Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology) (2011)
• American Society for Microbiology (2006)