Sebastian Winter, Ph.D.
Assistant Professor

Graduate School

(2010), Biology

• Dysbiosis of the Gut Microbiota
• Gut Microbiota Imbalance and Colorectal Cancer
• Host-Microbe Interactions During Episodes of Inflammation
• Metabolism and Virulence During Salmonella Infection
• Pathogenesis of Non-typhoidal Salmonella Infections

Featured Publications

Precision editing of the gut microbiota ameliorates colitis.

Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE Nature 2018 Jan 553 7687 208-211

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.

Gillis CC, Hughes ER, Spiga L, Winter MG, Zhu W, Furtado de Carvalho T, Chanin RB, Behrendt CL, Hooper LV, Santos RL, Winter SE Cell Host Microbe 2017 Dec

An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate.

Spiga L, Winter MG, Furtado de Carvalho T, Zhu W, Hughes ER, Gillis CC, Behrendt CL, Kim J, Chessa D, Andrews-Polymenis HL, Beiting DP, Santos RL, Hooper LV, Winter SE Cell Host Microbe 2017 Aug

Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis.

Hughes ER, Winter MG, Duerkop BA, Spiga L, Furtado de Carvalho T, Zhu W, Gillis CC, Büttner L, Smoot MP, Behrendt CL, Cherry S, Santos RL, Hooper LV, Winter SE Cell Host Microbe 2017 Feb 21 2 208-219

Using Enteric Pathogens to Probe the Gut Microbiota.

Spiga L, Winter SE Trends Microbiol. 2018 Dec

Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation.

Miyata N, Morris LL, Chen Q, Thorne C, Singla A, Zhu W, Winter M, Melton SD, Li H, Sifuentes-Dominguez L, Llano E, Huff-Hardy K, Starokadomskyy P, Lopez A, Reese TA, Turer E, Billadeau DD, Winter SE, Burstein E Cell Rep 2018 Aug 24 9 2342-2355

Murine colitis reveals a disease-associated bacteriophage community.

Duerkop BA, Kleiner M, Paez-Espino D, Zhu W, Bushnell B, Hassell B, Winter SE, Kyrpides NC, Hooper LV Nat Microbiol 2018 Jul

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.

Gillis CC, Hughes ER, Spiga L, Winter MG, Zhu W, Furtado de Carvalho T, Chanin RB, Behrendt CL, Hooper LV, Santos RL, Winter SE Cell Host Microbe 2018 Apr 23 4 570

Utilization of host polyamines in alternatively activated macrophages promotes chronic infection by Brucella abortus.

Kerrinnes T, Winter MG, Young BM, Diaz-Ochoa VE, Winter SE, Tsolis RM Infect. Immun. 2017 Dec

Bacteria Facilitate Enteric Virus Co-infection of Mammalian Cells and Promote Genetic Recombination.

Erickson AK, Jesudhasan PR, Mayer MJ, Narbad A, Winter SE, Pfeiffer JK Cell Host Microbe 2017 Dec

• BWF Investigator in the Pathogenesis of Infectious Disease
  Burroughs Wellcome Fund (2018)
• Research Scholar
  American Cancer Society (2017)
• ICAAC Young Investigator Award
  American Society for Microbiology (2014)
• Becton Dickinson Research Award
  Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology) (2011)

• Editorial Board, Clinical and Vaccine Immunology (2015-2017)
• Editorial Board, Infection and Immunity (2012)
• Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology) (2011)
• American Society for Microbiology (2006)