Sebastian Winter, Ph.D.
Assistant Professor

Graduate School

(2010), Biology

• Dysbiosis of the Gut Microbiota
• Gut Microbiota Imbalance and Colorectal Cancer
• Host-Microbe Interactions During Episodes of Inflammation
• Metabolism and Virulence During Salmonella Infection
• Pathogenesis of Non-typhoidal Salmonella Infections

Featured Publications

Xenosiderophore Utilization Promotes Bacteroides thetaiotaomicron Resilience during Colitis.

Zhu W, Winter MG, Spiga L, Hughes ER, Chanin R, Mulgaonkar A, Pennington J, Maas M, Behrendt CL, Kim J, Sun X, Beiting DP, Hooper LV, Winter SE, Cell Host Microbe 2020 Feb

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer.

Zhu W, Miyata N, Winter MG, Arenales A, Hughes ER, Spiga L, Kim J, Sifuentes-Dominguez L, Starokadomskyy P, Gopal P, Byndloss MX, Santos RL, Burstein E, Winter SE, J. Exp. Med. 2019 Jul

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.

Gillis CC, Hughes ER, Spiga L, Winter MG, Zhu W, Furtado de Carvalho T, Chanin RB, Behrendt CL, Hooper LV, Santos RL, Winter SE Cell Host Microbe 2018 Apr 23 4 570

Precision editing of the gut microbiota ameliorates colitis.

Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE Nature 2018 Jan 553 7687 208-211

An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate.

Spiga L, Winter MG, Furtado de Carvalho T, Zhu W, Hughes ER, Gillis CC, Behrendt CL, Kim J, Chessa D, Andrews-Polymenis HL, Beiting DP, Santos RL, Hooper LV, Winter SE Cell Host Microbe 2017 Aug

Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis.

Hughes ER, Winter MG, Duerkop BA, Spiga L, Furtado de Carvalho T, Zhu W, Gillis CC, Büttner L, Smoot MP, Behrendt CL, Cherry S, Santos RL, Hooper LV, Winter SE Cell Host Microbe 2017 Feb 21 2 208-219

l-Arginine sensing regulates virulence gene expression and disease progression in enteric pathogens.

Menezes-Garcia Z, Kumar A, Zhu W, Winter SE, Sperandio V, Proc. Natl. Acad. Sci. U.S.A. 2020 May

Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production.

Wang S, El-Fahmawi A, Christian DA, Fang Q, Radaelli E, Chen L, Sullivan MC, Misic AM, Ellringer JA, Zhu XQ, Winter SE, Hunter CA, Beiting DP, MBio 2019 May 10 3

STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium.

Wilson RP, Tursi SA, Rapsinski GJ, Medeiros NJ, Le LS, Kotredes KP, Patel S, Liverani E, Sun S, Zhu W, Kilpatrick L, Winter SE, Gamero AM, Tükel Ç, PLoS Pathog. 2019 Apr 15 4 e1007745

Transition metals and host-microbe interactions in the inflamed intestine.

Zhu W, Spiga L, Winter S, Biometals 2019 Feb

• BWF Investigator in the Pathogenesis of Infectious Disease
  Burroughs Wellcome Fund (2018)
• Research Scholar
  American Cancer Society (2017)
• ICAAC Young Investigator Award
  American Society for Microbiology (2014)
• Becton Dickinson Research Award
  Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology) (2011)

• Editorial Board, Clinical and Vaccine Immunology (2015-2017)
• Editorial Board, Infection and Immunity (2012-2020)
• Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology) (2011)
• American Society for Microbiology (2006)