
Sebastian Winter, Ph.D.
Associate Professor
Endowed Title W.W. Caruth, Jr. Scholar in Biomedical Research
Department Microbiology | Immunology
Graduate Programs Immunology, Molecular Microbiology
Education
- Graduate School
- (2010), Biology
Research Interest
- Dysbiosis of the Gut Microbiota
- Gut Microbiota Imbalance and Colorectal Cancer
- Host-Microbe Interactions During Episodes of Inflammation
- Metabolism and Virulence During Salmonella Infection
- Pathogenesis of Non-typhoidal Salmonella Infections
Publications
Featured Publications
- Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation.
- Hughes ER, Winter MG, Alves da Silva L, Muramatsu MK, Jimenez AG, Gillis CC, Spiga L, Chanin RB, Santos RL, Zhu W, Winter SE, Elife 2021 Jun 10
- Epithelial-Derived Reactive Oxygen Species Enable AppBCX-Mediated Aerobic Respiration of Escherichia coli during Intestinal Inflammation.
- Chanin RB, Winter MG, Spiga L, Hughes ER, Zhu W, Taylor SJ, Arenales A, Gillis CC, Büttner L, Jimenez AG, Smoot MP, Santos RL, Winter SE, Cell Host Microbe 2020 Sep
- Xenosiderophore Utilization Promotes Bacteroides thetaiotaomicron Resilience during Colitis.
- Zhu W, Winter MG, Spiga L, Hughes ER, Chanin R, Mulgaonkar A, Pennington J, Maas M, Behrendt CL, Kim J, Sun X, Beiting DP, Hooper LV, Winter SE, Cell Host Microbe 2020 Feb
- Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer.
- Zhu W, Miyata N, Winter MG, Arenales A, Hughes ER, Spiga L, Kim J, Sifuentes-Dominguez L, Starokadomskyy P, Gopal P, Byndloss MX, Santos RL, Burstein E, Winter SE, J. Exp. Med. 2019 Jul
- Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.
- Gillis CC, Hughes ER, Spiga L, Winter MG, Zhu W, Furtado de Carvalho T, Chanin RB, Behrendt CL, Hooper LV, Santos RL, Winter SE Cell Host Microbe 2018 Apr 23 4 570
- Precision editing of the gut microbiota ameliorates colitis.
- Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE Nature 2018 Jan 553 7687 208-211
- An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate.
- Spiga L, Winter MG, Furtado de Carvalho T, Zhu W, Hughes ER, Gillis CC, Behrendt CL, Kim J, Chessa D, Andrews-Polymenis HL, Beiting DP, Santos RL, Hooper LV, Winter SE Cell Host Microbe 2017 Aug
- Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis.
- Hughes ER, Winter MG, Duerkop BA, Spiga L, Furtado de Carvalho T, Zhu W, Gillis CC, Büttner L, Smoot MP, Behrendt CL, Cherry S, Santos RL, Hooper LV, Winter SE Cell Host Microbe 2017 Feb 21 2 208-219
- C4-dicarboxylates and l-aspartate utilization by Escherichia coli K-12 in the mouse intestine: l-aspartate as a major substrate for fumarate respiration and as a nitrogen source.
- Schubert C, Winter M, Ebert-Jung A, Kierszniowska S, Nagel-Wolfrum K, Schramm T, Link H, Winter S, Unden G, Environ Microbiol 2021 May 23 5 2564-2577
- Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens.
- Ellermann M, Pacheco AR, Jimenez AG, Russell RM, Cuesta S, Kumar A, Zhu W, Vale G, Martin SA, Raj P, McDonald JG, Winter SE, Sperandio V, Cell 2020 Sep
Honors & Awards
- BWF Investigator in the Pathogenesis of Infectious Disease
Burroughs Wellcome Fund (2018) - Research Scholar
American Cancer Society (2017) - ICAAC Young Investigator Award
American Society for Microbiology (2014) - Becton Dickinson Research Award
Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology) (2011)
Professional Associations/Affiliations
- Editorial Board, Clinical and Vaccine Immunology (2015-2017)
- Editorial Board, Infection and Immunity (2012-2020)
- Deutsche Gesellschaft für Hygiene und Mikrobiologie (German Society for Hygiene and Microbiology) (2011)
- American Society for Microbiology (2006)