Education

Undergraduate
University of Illinois Urbana (1969), Chemistry
Graduate School
Michigan State University (1974), Biochemistry

Research Interest

  • Cellular identity and cancer
  • Organogenesis
  • Transcriptional control of development

Publications

Featured Publications LegendFeatured Publications

Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation and Homeostasis by PTF1A.
Hoang CQ, Hale MA, Azevedo-Pouly A, Elsässer HP, Deering TG, Willet SG, Pan FC, Magnuson MA, Wright CV, Swift GH, MacDonald RJ Mol. Cell. Biol. 2016 Oct
MIST1 and PTF1 Collaborate in Feed-forward Regulatory Loops that Maintain the Pancreatic Acinar Phenotype in Adult Mice.
Jiang M, Azevedo-Pouly A, Deering TG, Hoang CQ, DiRenzo D, Hess DA, Konieczny SF, Swift GH, MacDonald RJ Mol. Cell. Biol. 2016 Sep
Isolated pancreatic aplasia due to a hypomorphic PTF1A mutation.
Houghton JA, Swift GH, Shaw-Smith C, Flanagan SE, de Franco E, Caswell R, Hussain K, Mohamed S, Abdulrasoul M, Hattersley AT, MacDonald RJ, Ellard S Diabetes 2016 Jun
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.
Krah NM, De La O JP, Swift GH, Hoang CQ, Willet SG, Chen Pan F, Cash GM, Bronner MP, Wright CV, MacDonald RJ, Murtaugh LC Elife 2015 Jul 4
The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell-formation and acinar differentiation during pancreatic organogenesis.
Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ Development 2014 Jul
Program specificity for Ptf1a in Pancreas versus Neural Tube Development correlates with distinct collaborating cofactors and chromatin accessibility.
Meredith DM, Borromeo MD, Deering TG, Casey B, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE Mol. Cell. Biol. 2013 Jun
Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.
Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ Gastroenterology 2010 Jul 139 1 270-80
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ Genes Dev. 2007 Oct 21 20 2629-43

Books

Featured Books Legend Featured Books