Dr. Gu is originally from China and received his Ph.D. in cell biology from Zhejiang University, China. His PhD thesis dealt with innate immunity. He completed his postdoctoral training in cancer biology at UT Southwestern. Dr. Gu’s current research interests focuses on tumor suppressor and developing genetically engineered mice models of renal tumors.

Research Interest

  • Genetically Engineered Mice Models for Renal Tumors
  • Tumor Suppressor Function in Kidney Cancer


Featured Publications LegendFeatured Publications

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.
Gu YF, Cohn S, Christie A, McKenzie T, Wolff NC, Do QN, Madhuranthakam A, Pedrosa I, Wang T, Dey A, Busslinger M, Xie XJ, Hammer RE, McKay RM, Kapur P, Brugarolas J Cancer Discov 2017 May
Characterization of SIGIRR/IL-1R8 Homolog from Zebrafish Provides New Insights into Its Inhibitory Role in Hepatic Inflammation.
Feng W, Gu YF, Nie L, Guo DY, Xiang LX, Shao JZ J. Immunol. 2016 07 197 1 151-67
Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis.
Wang SS, Gu YF, Wolff N, Stefanius K, Christie A, Dey A, Hammer RE, Xie XJ, Rakheja D, Pedrosa I, Carroll T, McKay RM, Kapur P, Brugarolas J Proc. Natl. Acad. Sci. U.S.A. 2014 Nov 111 46 16538-43
Discovery of the DIGIRR gene from teleost fish: a novel Toll-IL-1 receptor family member serving as a negative regulator of IL-1 signaling.
Gu YF, Fang Y, Jin Y, Dong WR, Xiang LX, Shao JZ J. Immunol. 2011 Sep 187 5 2514-30